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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei284Proton donorBy similarity1
Active sitei305By similarity1
Active sitei420By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-544
MPNE272634:G1GJ3-395-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:MPN_250
ORF Names:MP582
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806861 – 430Glucose-6-phosphate isomeraseAdd BLAST430

Structurei

3D structure databases

ProteinModelPortaliP78033
SMRiP78033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

KOiK01810
OMAiSFIIPDD

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P78033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKWLTVDT KHLYGFDEAI FIQKYQKKVN QIHQQFLNQQ LPDGHMNGWY
60 70 80 90 100
SQPDQDHKGL LKQINTIAKQ FNALKVTDIV YLGIGGSYTG IRAILDFLKP
110 120 130 140 150
EQKANIKVHF VPDISAFNIA AVARAIKGKS WALVVTSKSG RTLEPAVTFR
160 170 180 190 200
YFRNLLHKQY KQKHALRTVV ITDAVKGLLV GMSNQYGYAH LTIPSNIGGR
210 220 230 240 250
FSTLSPAGLL LAKLCGHDPK QLLLGTLTAK QELANSDLNT NSAYYYAALR
260 270 280 290 300
HWLYTTKKLK IEVTVAYHSA YEYLLLQHRQ LFGESEGKGG KSLFPTFSLF
310 320 330 340 350
TTDLHSMGQL YQEGEKNFFE TVIQVQTQFH DLELPPSDFN NDDQLDYLLA
360 370 380 390 400
KSMNEISNTA LEAVVEAHFQ SNVNIIKLTL KERTTFMFGY FYFWLSMATM
410 420 430
MSGSLLGHNV FDQPGVEVYK QLMFAKLGRE
Length:430
Mass (Da):48,834
Last modified:February 1, 1997 - v1
Checksum:iBBF48166F3DCBA70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96230.1
PIRiS73908
RefSeqiNP_109938.1, NC_000912.1
WP_010874607.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96230; AAB96230; MPN_250
GeneIDi876909
KEGGimpn:MPN250
PATRICifig|272634.6.peg.269

Similar proteinsi

Entry informationi

Entry nameiG6PI_MYCPN
AccessioniPrimary (citable) accession number: P78033
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health