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P78031

- KPYK_MYCPN

UniProt

P78031 - KPYK_MYCPN

Protein

Pyruvate kinase

Gene

pyk

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Enzyme regulationi

    Regulated by phosphoenolpyruvate substrate and is allosterically activated by ribose-5-phosphate, AMP and other nucleoside monophosphates but not by fructose-1,6-bisphosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Metal bindingi58 – 581PotassiumBy similarity
    Metal bindingi60 – 601PotassiumBy similarity
    Metal bindingi90 – 901PotassiumBy similarity
    Metal bindingi91 – 911Potassium; via carbonyl oxygenBy similarity
    Sitei249 – 2491Transition state stabilizerBy similarity
    Metal bindingi251 – 2511MagnesiumBy similarity
    Binding sitei274 – 2741Substrate; via amide nitrogenBy similarity
    Metal bindingi275 – 2751MagnesiumBy similarity
    Binding sitei275 – 2751Substrate; via amide nitrogenBy similarity
    Binding sitei307 – 3071SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-310-MONOMER.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    Ordered Locus Names:MPN_303
    ORF Names:MP533
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Pyruvate kinasePRO_0000112081Add
    BLAST

    Proteomic databases

    PaxDbiP78031.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiP78031. 2 interactions.
    STRINGi272634.MPN303.

    Structurei

    3D structure databases

    ProteinModelPortaliP78031.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    KOiK00873.
    OMAiGDETMIS.
    OrthoDBiEOG6GBMB0.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78031-1 [UniParc]FASTAAdd to Basket

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    MIHHLKRTKI IATCGPALTK KLWTLAMLDD PAYAAMKAEA YANIENIIKN    50
    GVTVIRLNFS HGNHEEQAVR IKIVRDVAKK LNLPVSIMLD TNGPEIRVFE 100
    TAPEGLKILK DSEVVINTTT KEVAKNNQFS VSDASGTYNM VNDVKVGQKI 150
    LVDDGKLSLV VKRIDTKNNQ VICVAQNDHT IFTKKRLNLP NADYSIPFLS 200
    AKDLRDIDFG LTHQIDYIAA SFVNTTENIK QLRDYLASKN AKHVKLIAKI 250
    ESNHALNNID GIIKASDGIM VARGDLGLEI PYYKVPYWQR YMIKACRFFN 300
    KRVITATQML DSLEKNIQPT RAEVTDVYFA VDRGNDATML SGETANGAFP 350
    LNAVYVMKMI DKQSETFFDY QYNLNYYMAN SKARHSEFWK QVVLPLAQKT 400
    APKRKLINSD FKYDFVVHAT NNLNEIYALS NARLAAAVII LTNDPQVYTG 450
    HGVDYGIFPY LIDQKPQSLS KAEFKSLANV AIKHYQQHGE ISQLKQCLGV 500
    FHNKIISL 508
    Length:508
    Mass (Da):57,268
    Last modified:February 1, 1997 - v1
    Checksum:i011D97377F8BB527
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96181.1.
    PIRiS73859.
    RefSeqiNP_109991.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96181; AAB96181; MPN_303.
    GeneIDi877217.
    KEGGimpn:MPN303.
    PATRICi20021941. VBIMycPne110_0327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96181.1 .
    PIRi S73859.
    RefSeqi NP_109991.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P78031.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P78031. 2 interactions.
    STRINGi 272634.MPN303.

    Proteomic databases

    PaxDbi P78031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96181 ; AAB96181 ; MPN_303 .
    GeneIDi 877217.
    KEGGi mpn:MPN303.
    PATRICi 20021941. VBIMycPne110_0327.

    Phylogenomic databases

    eggNOGi COG0469.
    KOi K00873.
    OMAi GDETMIS.
    OrthoDBi EOG6GBMB0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BioCyci MPNE272634:GJ6Z-310-MONOMER.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiKPYK_MYCPN
    AccessioniPrimary (citable) accession number: P78031
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3