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P78029

- TYSY_MYCPN

UniProt

P78029 - TYSY_MYCPN

Protein

Thymidylate synthase

Gene

thyA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-337-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:MPN_320
    ORF Names:MP516
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Thymidylate synthasePRO_0000140987Add
    BLAST

    Proteomic databases

    PaxDbiP78029.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiP78029. 3 interactions.
    STRINGi272634.MPN320.

    Structurei

    3D structure databases

    ProteinModelPortaliP78029.
    SMRiP78029. Positions 2-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    KOiK00560.
    OMAiDVHLYSN.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78029-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQYLDLARY VLEHGKYRPN RTDTAGIGVF GYQMHFDISK HFPLLTTKKV    50
    HWKSIVHELL WFIKGDTNIK YLVDNKVNIW NEWPYESFKK SPHFNGESQK 100
    EFIERIRQDA KFAQQFGNLG PVYGKQWRDF NGVDQLKKVI AQIKVNPFSR 150
    RLIVSSWNPN EVDQMLLPPC HSLYQFYVQD GQLSCQLYQR SGDIFLGIPF 200
    NIASYSLLVY LVAKETNLKP GSFVHTIGDA HIYENHLEQI KLQLTRQPKP 250
    LPKVVLKSDK SIFDYQFDDI ELVDYDHHPT IKGEVAV 287
    Length:287
    Mass (Da):33,591
    Last modified:November 1, 1997 - v2
    Checksum:iDAD2E84FCD9C5EDE
    GO

    Sequence cautioni

    The sequence AAB96164.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2129SYSLLVYLV → FLLSYGA(PubMed:7984111)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96164.1. Different initiation.
    Z32654 Genomic DNA. Translation: CAA83575.1.
    PIRiS73842.
    RefSeqiNP_110008.2. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96164; AAB96164; MPN_320.
    GeneIDi876944.
    KEGGimpn:MPN320.
    PATRICi20021994. VBIMycPne110_0344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96164.1 . Different initiation.
    Z32654 Genomic DNA. Translation: CAA83575.1 .
    PIRi S73842.
    RefSeqi NP_110008.2. NC_000912.1.

    3D structure databases

    ProteinModelPortali P78029.
    SMRi P78029. Positions 2-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P78029. 3 interactions.
    STRINGi 272634.MPN320.

    Proteomic databases

    PaxDbi P78029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96164 ; AAB96164 ; MPN_320 .
    GeneIDi 876944.
    KEGGi mpn:MPN320.
    PATRICi 20021994. VBIMycPne110_0344.

    Phylogenomic databases

    eggNOGi COG0207.
    KOi K00560.
    OMAi DVHLYSN.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci MPNE272634:GJ6Z-337-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.
    2. "Identification and characterization of hitherto unknown Mycoplasma pneumoniae proteins."
      Proft T., Herrmann R.
      Mol. Microbiol. 13:337-348(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 163-212.
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiTYSY_MYCPN
    AccessioniPrimary (citable) accession number: P78029
    Secondary accession number(s): Q50354
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3