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P78018

- PGK_MYCPN

UniProt

P78018 - PGK_MYCPN

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei164 – 1641SubstrateBy similarity
    Binding sitei215 – 2151ATPBy similarity
    Binding sitei338 – 3381ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi365 – 3684ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-549.
    MPNE272634:GJ6Z-458-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:MPN_429
    ORF Names:MP412
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Phosphoglycerate kinasePRO_0000145971Add
    BLAST

    Proteomic databases

    PaxDbiP78018.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP78018. 2 interactions.
    STRINGi272634.MPN429.

    Structurei

    3D structure databases

    ProteinModelPortaliP78018.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 243Substrate bindingBy similarity
    Regioni60 – 634Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78018-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDFKTVQAF DFQGKTVVLR ADLNVPMKDG VITDNERILA SLDTIKYLLG    50
    HNCKIVLLSH LSRVKSLDDK KGKKSLQPVA SALQNLLKNT KVHFCPENTG 100
    DKVKVAVNQL PLGEILVLEN TRYCDVNEAG EVVKHESKNN AELAQFWASL 150
    GDIFVNDAFG TAHRRHASNA GIAKYIKNSC IGLLMERELI NLYRLINNPP 200
    KPFVVVLGGA KVSDKLQVVN NLFKIADHIL IGGGMVNTFL KALGNEVGTS 250
    LVEEDLVQTA KQILDSDKDK KIVLGVDQML HASFKDEPGV ECVVAPQWPA 300
    ELQGFMSLDV GSKTVALFSS YLAKAKTIFW NGPMGVFEFS NYAQGTLAIG 350
    KAIAQNQQAF SVIGGGDSAA AAKQLQIADQ FSFISTGGGA SLALIGGEEL 400
    VGISDIQKK 409
    Length:409
    Mass (Da):44,212
    Last modified:February 1, 1997 - v1
    Checksum:i6AF230188D398731
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96060.1.
    PIRiS73738.
    RefSeqiNP_110117.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96060; AAB96060; MPN_429.
    GeneIDi876849.
    KEGGimpn:MPN429.
    PATRICi20022254. VBIMycPne110_0464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB96060.1 .
    PIRi S73738.
    RefSeqi NP_110117.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P78018.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P78018. 2 interactions.
    STRINGi 272634.MPN429.

    Proteomic databases

    PaxDbi P78018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96060 ; AAB96060 ; MPN_429 .
    GeneIDi 876849.
    KEGGi mpn:MPN429.
    PATRICi 20022254. VBIMycPne110_0464.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci MetaCyc:MONOMER-549.
    MPNE272634:GJ6Z-458-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiPGK_MYCPN
    AccessioniPrimary (citable) accession number: P78018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3