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P78017

- GRPE_MYCPN

UniProt

P78017 - GRPE_MYCPN

Protein

Protein GrpE

Gene

grpE

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-126-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GrpEUniRule annotation
    Alternative name(s):
    HSP-70 cofactorUniRule annotation
    Gene namesi
    Name:grpEUniRule annotation
    Ordered Locus Names:MPN_120
    ORF Names:MP034
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Protein GrpEPRO_0000113821Add
    BLAST

    Proteomic databases

    PaxDbiP78017.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiP78017. 1 interaction.
    STRINGi272634.MPN120.

    Structurei

    3D structure databases

    ProteinModelPortaliP78017.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0576.
    KOiK03687.
    OMAiSSFMEAT.
    OrthoDBiEOG64BQ6C.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    PRINTSiPR00773. GRPEPROTEIN.
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78017-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENSLTITE ILSSIRTLLV KHNKAKVTQI EKELLQAVAE LEKKFKQQVQ    50
    NFNELQQKIP NLQKVNEEFR LKVEKIQEEA QKKIQEKVAE LTIKSKEELE 100
    NAKKYVIEKS IDQPLIIIDQ FEIALSYAQK DPQVKNYTTG FNMVLDAFSR 150
    WLEGFGVTKI AIEPGAQFDE KVMAALEVVP SDQPANTVVK VSKSGYKLHD 200
    KVIRFASVVV SQGNKTE 217
    Length:217
    Mass (Da):24,706
    Last modified:February 1, 1997 - v1
    Checksum:i3C66757AF4BEBEC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95682.1.
    PIRiS73360.
    RefSeqiNP_109808.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95682; AAB95682; MPN_120.
    GeneIDi877237.
    KEGGimpn:MPN120.
    PATRICi20021539. VBIMycPne110_0127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95682.1 .
    PIRi S73360.
    RefSeqi NP_109808.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P78017.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P78017. 1 interaction.
    STRINGi 272634.MPN120.

    Proteomic databases

    PaxDbi P78017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95682 ; AAB95682 ; MPN_120 .
    GeneIDi 877237.
    KEGGi mpn:MPN120.
    PATRICi 20021539. VBIMycPne110_0127.

    Phylogenomic databases

    eggNOGi COG0576.
    KOi K03687.
    OMAi SSFMEAT.
    OrthoDBi EOG64BQ6C.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-126-MONOMER.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    PRINTSi PR00773. GRPEPROTEIN.
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.
    2. "Towards a two-dimensional proteome map of Mycoplasma pneumoniae."
      Regula J.T., Ueberle B., Boguth G., Goerg A., Schnoelzer M., Herrmann R., Frank R.
      Electrophoresis 21:3765-3780(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiGRPE_MYCPN
    AccessioniPrimary (citable) accession number: P78017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3