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P78017

- GRPE_MYCPN

UniProt

P78017 - GRPE_MYCPN

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Protein

Protein GrpE

Gene

grpE

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:MPN_120
ORF Names:MP034
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Protein GrpEPRO_0000113821Add
BLAST

Proteomic databases

PaxDbiP78017.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP78017. 1 interaction.
STRINGi272634.MPN120.

Structurei

3D structure databases

ProteinModelPortaliP78017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0576.
KOiK03687.
OMAiSSFMEAT.
OrthoDBiEOG64BQ6C.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78017-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENSLTITE ILSSIRTLLV KHNKAKVTQI EKELLQAVAE LEKKFKQQVQ
60 70 80 90 100
NFNELQQKIP NLQKVNEEFR LKVEKIQEEA QKKIQEKVAE LTIKSKEELE
110 120 130 140 150
NAKKYVIEKS IDQPLIIIDQ FEIALSYAQK DPQVKNYTTG FNMVLDAFSR
160 170 180 190 200
WLEGFGVTKI AIEPGAQFDE KVMAALEVVP SDQPANTVVK VSKSGYKLHD
210
KVIRFASVVV SQGNKTE
Length:217
Mass (Da):24,706
Last modified:February 1, 1997 - v1
Checksum:i3C66757AF4BEBEC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95682.1.
PIRiS73360.
RefSeqiNP_109808.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95682; AAB95682; MPN_120.
GeneIDi877237.
KEGGimpn:MPN120.
PATRICi20021539. VBIMycPne110_0127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95682.1 .
PIRi S73360.
RefSeqi NP_109808.1. NC_000912.1.

3D structure databases

ProteinModelPortali P78017.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P78017. 1 interaction.
STRINGi 272634.MPN120.

Proteomic databases

PaxDbi P78017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95682 ; AAB95682 ; MPN_120 .
GeneIDi 877237.
KEGGi mpn:MPN120.
PATRICi 20021539. VBIMycPne110_0127.

Phylogenomic databases

eggNOGi COG0576.
KOi K03687.
OMAi SSFMEAT.
OrthoDBi EOG64BQ6C.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-126-MONOMER.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
PRINTSi PR00773. GRPEPROTEIN.
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.
  2. "Towards a two-dimensional proteome map of Mycoplasma pneumoniae."
    Regula J.T., Ueberle B., Boguth G., Goerg A., Schnoelzer M., Herrmann R., Frank R.
    Electrophoresis 21:3765-3780(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiGRPE_MYCPN
AccessioniPrimary (citable) accession number: P78017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3