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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-846-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:MPN_516
ORF Names:MP326
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000479221 – 1391DNA-directed RNA polymerase subunit betaAdd BLAST1391

Proteomic databases

PRIDEiP78013

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

IntActiP78013, 14 interactors

Structurei

3D structure databases

ProteinModelPortaliP78013
SMRiP78013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

KOiK03043
OMAiFMTWEGY

Family and domain databases

CDDicd00653 RNA_pol_B_RPB2, 1 hit
Gene3Di2.40.270.10, 3 hits
2.40.50.150, 1 hit
3.90.1110.10, 2 hits
HAMAPiMF_01321 RNApol_bact_RpoB, 1 hit
InterProiView protein in InterPro
IPR019462 DNA-dir_RNA_pol_bsu_external_1
IPR015712 DNA-dir_RNA_pol_su2
IPR007120 DNA-dir_RNAP_su2_dom
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR010243 RNA_pol_bsu_bac
IPR007121 RNA_pol_bsu_CS
IPR007644 RNA_pol_bsu_protrusion
IPR037034 RNA_pol_Rpb2_2_sf
IPR007645 RNA_pol_Rpb2_3
IPR007641 RNA_pol_Rpb2_7
IPR014724 RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856 PTHR20856, 1 hit
PfamiView protein in Pfam
PF04563 RNA_pol_Rpb2_1, 1 hit
PF04565 RNA_pol_Rpb2_3, 1 hit
PF10385 RNA_pol_Rpb2_45, 1 hit
PF00562 RNA_pol_Rpb2_6, 1 hit
PF04560 RNA_pol_Rpb2_7, 1 hit
TIGRFAMsiTIGR02013 rpoB, 1 hit
PROSITEiView protein in PROSITE
PS01166 RNA_POL_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P78013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKPSFFQK KYSPTATRRY YGKIATDFVQ PNLADIQIRS YQTFLDHDLE
60 70 80 90 100
NLIAAYFPIK SPNDRYTINF KGLRRTAPER NEAQSRSESK TYEIGIYADL
110 120 130 140 150
ELIDSATGTI KKPRKSKKNS ATSSVDGVFL TNLPLITRDG VFIVNGIEKF
160 170 180 190 200
VIAQITRSPG IYMLTKSQLK LSSSRKRVQE GYVCEVLPAN GSVMLIYISN
210 220 230 240 250
KKKIEDAFVQ ILLRDAVREG AKIFPITTLL KAFGMSGKEI LKVFKNNEFI
260 270 280 290 300
TRSLEAEVYN AKDFLNNVDP EIKNLLREFR DGKTDLRRKG IASDQKIRSL
310 320 330 340 350
VSDYVLLEKE HKALSEAKPN DPKVGQLEAD MDELMDKIIT ERAAKHIVHE
360 370 380 390 400
LSISLRGLEN TDECPENSYH ALLCSRFFRQ RRYNLSAAGR YKVSRKLRIT
410 420 430 440 450
ERIYQKTLAC DLHLKNGELL LKKGTLLVKE EIDKIKQAAQ NNQIDFVQKI
460 470 480 490 500
KLTTDGSAVN LSPESLLYES LDVYVNNDNF DVSVPVVGIH NDNDLNKAIT
510 520 530 540 550
LSDFIASISY VINIPSAIGK YDDIDHLGNK RVKLINELIS SRLESGITRM
560 570 580 590 600
ERFLKEKLTI ADGVNRGQQI NEEGQVIEQA EKKELTIKSL INSKPIQIVI
610 620 630 640 650
RDFFNTHQLT QFLDHQNPLS ELSNKRRISA MGPGGISRED PNLDIRDVHY
660 670 680 690 700
SQYGRICPIE TPEGMNIGLI MSLASFAKID ENGFLMAPYR KIKNGVITDE
710 720 730 740 750
VEYLTALRED EHIIAEISSL VNIDENNKIL DKEIIGRYRS MQGLYDPSKI
760 770 780 790 800
DYIDVAPHQV VSIGSSLIPF LENDDSARAL MGTNMQRQAY PLIKPYAPVV
810 820 830 840 850
GTGQEYKIAR DSGLTMLAPC SGTVKYVDNS KITIESDSGE QHTLDLIKFE
860 870 880 890 900
RSNQNTCYNH VPLVEKGQRV TKDEVIADGP AVNKSELSLG QNVLVAFTTW
910 920 930 940 950
NGYNYEDAIV ISERLVKDDV LTSLTINEYV AQCLSTKNGD EQITRDIPNV
960 970 980 990 1000
SDANKRYLDE NGIIMVGAEV KEGDVLVGKV SPKGQVEVSP EEKLFKAIFP
1010 1020 1030 1040 1050
ESVQNVRDSS LKLPHGGDGI VSCVKRFSIA NGNELNDGVI EMIKVYVVQK
1060 1070 1080 1090 1100
RKIQIGDKLA GRHGNKGVIS KVVPVADMPH LEDGTPVDIL LNPLGVPSRM
1110 1120 1130 1140 1150
NIGQIFEMHL GYAAHNLAKR MLISACFDDK KAQALSTEIN QPQYKLDRLI
1160 1170 1180 1190 1200
TGLKAQITNR GLKDEQAALA QLNNGDIALV LKEIGMSFDD LHFKVATPIF
1210 1220 1230 1240 1250
QGVNFQDLQD IMDEAGLKPA ETHGKFKLID GRTGLPFEKP ISLGIMYIMK
1260 1270 1280 1290 1300
LNHMVDDKIH ARAVGPYSKI TQQPLGGKSQ NGGQRFGEME VWALEAYGAA
1310 1320 1330 1340 1350
YNLQELLTIK SDDVQGRNKA YAAIVKGAAF PEPGIPESFK LLTKELQGLA
1360 1370 1380 1390
LSVSFIYDDN TQQDSNNVSI LQADGEQDDL FNDFEFDTEG Y
Length:1,391
Mass (Da):155,622
Last modified:February 1, 1997 - v1
Checksum:iB2F345AB24F18EAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB95974.1
PIRiS73652
RefSeqiNP_110204.1, NC_000912.1
WP_010874872.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB95974; AAB95974; MPN_516
GeneIDi876806
KEGGimpn:MPN516
PATRICifig|272634.6.peg.570

Similar proteinsi

Entry informationi

Entry nameiRPOB_MYCPN
AccessioniPrimary (citable) accession number: P78013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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