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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP
  3. ribonucleoside binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:MPN_516
ORF Names:MP326
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13911391DNA-directed RNA polymerase subunit betaPRO_0000047922Add
BLAST

Proteomic databases

PaxDbiP78013.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

IntActiP78013. 14 interactions.
STRINGi272634.MPN516.

Structurei

3D structure databases

ProteinModelPortaliP78013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0085.
KOiK03043.
OMAiTGRYMLN.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 3 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78013-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQKPSFFQK KYSPTATRRY YGKIATDFVQ PNLADIQIRS YQTFLDHDLE
60 70 80 90 100
NLIAAYFPIK SPNDRYTINF KGLRRTAPER NEAQSRSESK TYEIGIYADL
110 120 130 140 150
ELIDSATGTI KKPRKSKKNS ATSSVDGVFL TNLPLITRDG VFIVNGIEKF
160 170 180 190 200
VIAQITRSPG IYMLTKSQLK LSSSRKRVQE GYVCEVLPAN GSVMLIYISN
210 220 230 240 250
KKKIEDAFVQ ILLRDAVREG AKIFPITTLL KAFGMSGKEI LKVFKNNEFI
260 270 280 290 300
TRSLEAEVYN AKDFLNNVDP EIKNLLREFR DGKTDLRRKG IASDQKIRSL
310 320 330 340 350
VSDYVLLEKE HKALSEAKPN DPKVGQLEAD MDELMDKIIT ERAAKHIVHE
360 370 380 390 400
LSISLRGLEN TDECPENSYH ALLCSRFFRQ RRYNLSAAGR YKVSRKLRIT
410 420 430 440 450
ERIYQKTLAC DLHLKNGELL LKKGTLLVKE EIDKIKQAAQ NNQIDFVQKI
460 470 480 490 500
KLTTDGSAVN LSPESLLYES LDVYVNNDNF DVSVPVVGIH NDNDLNKAIT
510 520 530 540 550
LSDFIASISY VINIPSAIGK YDDIDHLGNK RVKLINELIS SRLESGITRM
560 570 580 590 600
ERFLKEKLTI ADGVNRGQQI NEEGQVIEQA EKKELTIKSL INSKPIQIVI
610 620 630 640 650
RDFFNTHQLT QFLDHQNPLS ELSNKRRISA MGPGGISRED PNLDIRDVHY
660 670 680 690 700
SQYGRICPIE TPEGMNIGLI MSLASFAKID ENGFLMAPYR KIKNGVITDE
710 720 730 740 750
VEYLTALRED EHIIAEISSL VNIDENNKIL DKEIIGRYRS MQGLYDPSKI
760 770 780 790 800
DYIDVAPHQV VSIGSSLIPF LENDDSARAL MGTNMQRQAY PLIKPYAPVV
810 820 830 840 850
GTGQEYKIAR DSGLTMLAPC SGTVKYVDNS KITIESDSGE QHTLDLIKFE
860 870 880 890 900
RSNQNTCYNH VPLVEKGQRV TKDEVIADGP AVNKSELSLG QNVLVAFTTW
910 920 930 940 950
NGYNYEDAIV ISERLVKDDV LTSLTINEYV AQCLSTKNGD EQITRDIPNV
960 970 980 990 1000
SDANKRYLDE NGIIMVGAEV KEGDVLVGKV SPKGQVEVSP EEKLFKAIFP
1010 1020 1030 1040 1050
ESVQNVRDSS LKLPHGGDGI VSCVKRFSIA NGNELNDGVI EMIKVYVVQK
1060 1070 1080 1090 1100
RKIQIGDKLA GRHGNKGVIS KVVPVADMPH LEDGTPVDIL LNPLGVPSRM
1110 1120 1130 1140 1150
NIGQIFEMHL GYAAHNLAKR MLISACFDDK KAQALSTEIN QPQYKLDRLI
1160 1170 1180 1190 1200
TGLKAQITNR GLKDEQAALA QLNNGDIALV LKEIGMSFDD LHFKVATPIF
1210 1220 1230 1240 1250
QGVNFQDLQD IMDEAGLKPA ETHGKFKLID GRTGLPFEKP ISLGIMYIMK
1260 1270 1280 1290 1300
LNHMVDDKIH ARAVGPYSKI TQQPLGGKSQ NGGQRFGEME VWALEAYGAA
1310 1320 1330 1340 1350
YNLQELLTIK SDDVQGRNKA YAAIVKGAAF PEPGIPESFK LLTKELQGLA
1360 1370 1380 1390
LSVSFIYDDN TQQDSNNVSI LQADGEQDDL FNDFEFDTEG Y
Length:1,391
Mass (Da):155,622
Last modified:February 1, 1997 - v1
Checksum:iB2F345AB24F18EAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95974.1.
PIRiS73652.
RefSeqiNP_110204.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95974; AAB95974; MPN_516.
GeneIDi876806.
KEGGimpn:MPN516.
PATRICi20022486. VBIMycPne110_0570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95974.1.
PIRiS73652.
RefSeqiNP_110204.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP78013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP78013. 14 interactions.
STRINGi272634.MPN516.

Proteomic databases

PaxDbiP78013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB95974; AAB95974; MPN_516.
GeneIDi876806.
KEGGimpn:MPN516.
PATRICi20022486. VBIMycPne110_0570.

Phylogenomic databases

eggNOGiCOG0085.
KOiK03043.
OMAiTGRYMLN.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-557-MONOMER.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 3 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiRPOB_MYCPN
AccessioniPrimary (citable) accession number: P78013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.