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P78013

- RPOB_MYCPN

UniProt

P78013 - RPOB_MYCPN

Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP
    3. ribonucleoside binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-557-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
    Short name:
    RNAP subunit betaUniRule annotation
    Alternative name(s):
    RNA polymerase subunit betaUniRule annotation
    Transcriptase subunit betaUniRule annotation
    Gene namesi
    Name:rpoBUniRule annotation
    Ordered Locus Names:MPN_516
    ORF Names:MP326
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13911391DNA-directed RNA polymerase subunit betaPRO_0000047922Add
    BLAST

    Proteomic databases

    PaxDbiP78013.

    Interactioni

    Subunit structurei

    The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

    Protein-protein interaction databases

    IntActiP78013. 14 interactions.
    STRINGi272634.MPN516.

    Structurei

    3D structure databases

    ProteinModelPortaliP78013.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0085.
    KOiK03043.
    OMAiENDDSAR.
    OrthoDBiEOG6M9DS6.

    Family and domain databases

    Gene3Di2.30.150.10. 1 hit.
    2.40.270.10. 2 hits.
    2.40.50.150. 1 hit.
    3.90.1110.10. 3 hits.
    HAMAPiMF_01321. RNApol_bact_RpoB.
    InterProiIPR010243. DNA-dir_RNA_pol_bsu.
    IPR019462. DNA-dir_RNA_pol_bsu_external_1.
    IPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view]
    PANTHERiPTHR20856. PTHR20856. 1 hit.
    PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF10385. RNA_pol_Rpb2_45. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02013. rpoB. 1 hit.
    PROSITEiPS01166. RNA_POL_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78013-1 [UniParc]FASTAAdd to Basket

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    MSQKPSFFQK KYSPTATRRY YGKIATDFVQ PNLADIQIRS YQTFLDHDLE     50
    NLIAAYFPIK SPNDRYTINF KGLRRTAPER NEAQSRSESK TYEIGIYADL 100
    ELIDSATGTI KKPRKSKKNS ATSSVDGVFL TNLPLITRDG VFIVNGIEKF 150
    VIAQITRSPG IYMLTKSQLK LSSSRKRVQE GYVCEVLPAN GSVMLIYISN 200
    KKKIEDAFVQ ILLRDAVREG AKIFPITTLL KAFGMSGKEI LKVFKNNEFI 250
    TRSLEAEVYN AKDFLNNVDP EIKNLLREFR DGKTDLRRKG IASDQKIRSL 300
    VSDYVLLEKE HKALSEAKPN DPKVGQLEAD MDELMDKIIT ERAAKHIVHE 350
    LSISLRGLEN TDECPENSYH ALLCSRFFRQ RRYNLSAAGR YKVSRKLRIT 400
    ERIYQKTLAC DLHLKNGELL LKKGTLLVKE EIDKIKQAAQ NNQIDFVQKI 450
    KLTTDGSAVN LSPESLLYES LDVYVNNDNF DVSVPVVGIH NDNDLNKAIT 500
    LSDFIASISY VINIPSAIGK YDDIDHLGNK RVKLINELIS SRLESGITRM 550
    ERFLKEKLTI ADGVNRGQQI NEEGQVIEQA EKKELTIKSL INSKPIQIVI 600
    RDFFNTHQLT QFLDHQNPLS ELSNKRRISA MGPGGISRED PNLDIRDVHY 650
    SQYGRICPIE TPEGMNIGLI MSLASFAKID ENGFLMAPYR KIKNGVITDE 700
    VEYLTALRED EHIIAEISSL VNIDENNKIL DKEIIGRYRS MQGLYDPSKI 750
    DYIDVAPHQV VSIGSSLIPF LENDDSARAL MGTNMQRQAY PLIKPYAPVV 800
    GTGQEYKIAR DSGLTMLAPC SGTVKYVDNS KITIESDSGE QHTLDLIKFE 850
    RSNQNTCYNH VPLVEKGQRV TKDEVIADGP AVNKSELSLG QNVLVAFTTW 900
    NGYNYEDAIV ISERLVKDDV LTSLTINEYV AQCLSTKNGD EQITRDIPNV 950
    SDANKRYLDE NGIIMVGAEV KEGDVLVGKV SPKGQVEVSP EEKLFKAIFP 1000
    ESVQNVRDSS LKLPHGGDGI VSCVKRFSIA NGNELNDGVI EMIKVYVVQK 1050
    RKIQIGDKLA GRHGNKGVIS KVVPVADMPH LEDGTPVDIL LNPLGVPSRM 1100
    NIGQIFEMHL GYAAHNLAKR MLISACFDDK KAQALSTEIN QPQYKLDRLI 1150
    TGLKAQITNR GLKDEQAALA QLNNGDIALV LKEIGMSFDD LHFKVATPIF 1200
    QGVNFQDLQD IMDEAGLKPA ETHGKFKLID GRTGLPFEKP ISLGIMYIMK 1250
    LNHMVDDKIH ARAVGPYSKI TQQPLGGKSQ NGGQRFGEME VWALEAYGAA 1300
    YNLQELLTIK SDDVQGRNKA YAAIVKGAAF PEPGIPESFK LLTKELQGLA 1350
    LSVSFIYDDN TQQDSNNVSI LQADGEQDDL FNDFEFDTEG Y 1391
    Length:1,391
    Mass (Da):155,622
    Last modified:February 1, 1997 - v1
    Checksum:iB2F345AB24F18EAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95974.1.
    PIRiS73652.
    RefSeqiNP_110204.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95974; AAB95974; MPN_516.
    GeneIDi876806.
    KEGGimpn:MPN516.
    PATRICi20022486. VBIMycPne110_0570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95974.1 .
    PIRi S73652.
    RefSeqi NP_110204.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P78013.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P78013. 14 interactions.
    STRINGi 272634.MPN516.

    Proteomic databases

    PaxDbi P78013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95974 ; AAB95974 ; MPN_516 .
    GeneIDi 876806.
    KEGGi mpn:MPN516.
    PATRICi 20022486. VBIMycPne110_0570.

    Phylogenomic databases

    eggNOGi COG0085.
    KOi K03043.
    OMAi ENDDSAR.
    OrthoDBi EOG6M9DS6.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-557-MONOMER.

    Family and domain databases

    Gene3Di 2.30.150.10. 1 hit.
    2.40.270.10. 2 hits.
    2.40.50.150. 1 hit.
    3.90.1110.10. 3 hits.
    HAMAPi MF_01321. RNApol_bact_RpoB.
    InterProi IPR010243. DNA-dir_RNA_pol_bsu.
    IPR019462. DNA-dir_RNA_pol_bsu_external_1.
    IPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view ]
    PANTHERi PTHR20856. PTHR20856. 1 hit.
    Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF10385. RNA_pol_Rpb2_45. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02013. rpoB. 1 hit.
    PROSITEi PS01166. RNA_POL_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiRPOB_MYCPN
    AccessioniPrimary (citable) accession number: P78013
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3