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P78013 (RPOB_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta

Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:MPN_516
ORF Names:MP326
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length1391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. HAMAP-Rule MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13911391DNA-directed RNA polymerase subunit beta HAMAP-Rule MF_01321
PRO_0000047922

Sequences

Sequence LengthMass (Da)Tools
P78013 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: B2F345AB24F18EAD

FASTA1,391155,622
        10         20         30         40         50         60 
MSQKPSFFQK KYSPTATRRY YGKIATDFVQ PNLADIQIRS YQTFLDHDLE NLIAAYFPIK 

        70         80         90        100        110        120 
SPNDRYTINF KGLRRTAPER NEAQSRSESK TYEIGIYADL ELIDSATGTI KKPRKSKKNS 

       130        140        150        160        170        180 
ATSSVDGVFL TNLPLITRDG VFIVNGIEKF VIAQITRSPG IYMLTKSQLK LSSSRKRVQE 

       190        200        210        220        230        240 
GYVCEVLPAN GSVMLIYISN KKKIEDAFVQ ILLRDAVREG AKIFPITTLL KAFGMSGKEI 

       250        260        270        280        290        300 
LKVFKNNEFI TRSLEAEVYN AKDFLNNVDP EIKNLLREFR DGKTDLRRKG IASDQKIRSL 

       310        320        330        340        350        360 
VSDYVLLEKE HKALSEAKPN DPKVGQLEAD MDELMDKIIT ERAAKHIVHE LSISLRGLEN 

       370        380        390        400        410        420 
TDECPENSYH ALLCSRFFRQ RRYNLSAAGR YKVSRKLRIT ERIYQKTLAC DLHLKNGELL 

       430        440        450        460        470        480 
LKKGTLLVKE EIDKIKQAAQ NNQIDFVQKI KLTTDGSAVN LSPESLLYES LDVYVNNDNF 

       490        500        510        520        530        540 
DVSVPVVGIH NDNDLNKAIT LSDFIASISY VINIPSAIGK YDDIDHLGNK RVKLINELIS 

       550        560        570        580        590        600 
SRLESGITRM ERFLKEKLTI ADGVNRGQQI NEEGQVIEQA EKKELTIKSL INSKPIQIVI 

       610        620        630        640        650        660 
RDFFNTHQLT QFLDHQNPLS ELSNKRRISA MGPGGISRED PNLDIRDVHY SQYGRICPIE 

       670        680        690        700        710        720 
TPEGMNIGLI MSLASFAKID ENGFLMAPYR KIKNGVITDE VEYLTALRED EHIIAEISSL 

       730        740        750        760        770        780 
VNIDENNKIL DKEIIGRYRS MQGLYDPSKI DYIDVAPHQV VSIGSSLIPF LENDDSARAL 

       790        800        810        820        830        840 
MGTNMQRQAY PLIKPYAPVV GTGQEYKIAR DSGLTMLAPC SGTVKYVDNS KITIESDSGE 

       850        860        870        880        890        900 
QHTLDLIKFE RSNQNTCYNH VPLVEKGQRV TKDEVIADGP AVNKSELSLG QNVLVAFTTW 

       910        920        930        940        950        960 
NGYNYEDAIV ISERLVKDDV LTSLTINEYV AQCLSTKNGD EQITRDIPNV SDANKRYLDE 

       970        980        990       1000       1010       1020 
NGIIMVGAEV KEGDVLVGKV SPKGQVEVSP EEKLFKAIFP ESVQNVRDSS LKLPHGGDGI 

      1030       1040       1050       1060       1070       1080 
VSCVKRFSIA NGNELNDGVI EMIKVYVVQK RKIQIGDKLA GRHGNKGVIS KVVPVADMPH 

      1090       1100       1110       1120       1130       1140 
LEDGTPVDIL LNPLGVPSRM NIGQIFEMHL GYAAHNLAKR MLISACFDDK KAQALSTEIN 

      1150       1160       1170       1180       1190       1200 
QPQYKLDRLI TGLKAQITNR GLKDEQAALA QLNNGDIALV LKEIGMSFDD LHFKVATPIF 

      1210       1220       1230       1240       1250       1260 
QGVNFQDLQD IMDEAGLKPA ETHGKFKLID GRTGLPFEKP ISLGIMYIMK LNHMVDDKIH 

      1270       1280       1290       1300       1310       1320 
ARAVGPYSKI TQQPLGGKSQ NGGQRFGEME VWALEAYGAA YNLQELLTIK SDDVQGRNKA 

      1330       1340       1350       1360       1370       1380 
YAAIVKGAAF PEPGIPESFK LLTKELQGLA LSVSFIYDDN TQQDSNNVSI LQADGEQDDL 

      1390 
FNDFEFDTEG Y 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB95974.1.
PIRS73652.
RefSeqNP_110204.1. NC_000912.1.

3D structure databases

ProteinModelPortalP78013.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP78013. 14 interactions.
STRING272634.MPN516.

Proteomic databases

PaxDbP78013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95974; AAB95974; MPN_516.
GeneID876806.
KEGGmpn:MPN516.
PATRIC20022486. VBIMycPne110_0570.

Phylogenomic databases

eggNOGCOG0085.
KOK03043.
OMAENDDSAR.
OrthoDBEOG6M9DS6.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-557-MONOMER.

Family and domain databases

Gene3D2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 3 hits.
HAMAPMF_01321. RNApol_bact_RpoB.
InterProIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERPTHR20856. PTHR20856. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. rpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_MYCPN
AccessionPrimary (citable) accession number: P78013
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names