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Protein

60 kDa chaperonin

Gene

groL

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:MPN_573
ORF Names:MP269
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000634451 – 54360 kDa chaperoninAdd BLAST543

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
mnmEP751043EBI-2258565,EBI-2259625

Protein-protein interaction databases

IntActiP78012. 11 interactors.

Structurei

3D structure databases

ProteinModelPortaliP78012.
SMRiP78012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

P78012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKELVFGKN ARNKLLAGIN KLADAVKVTV GPKGQNVILG RKFSNPLITN
60 70 80 90 100
DGVTIAKEIE LTDPLENIGA KVISVAAVST NDIAGDGTTT ATILAQEMTN
110 120 130 140 150
RGVEAVNNGA NPVNVRRGIE DASQLIITEL DKRSKKINTN EEIEQVAAIS
160 170 180 190 200
SGSKEIGKLI AQAMALVGKN GVITTDDAKT INTTLETTEG IEFKGTYASP
210 220 230 240 250
YMVSDQEKME VVLDQPKILV SAMKINTIKE ILPLLEGSME NGNPLLIVAP
260 270 280 290 300
DFAEEVVTTL AVNKLRGTIN VVAVKCNEYG ERQKAALEDL AISTGTLAYN
310 320 330 340 350
NELGGGFKDV TVNHLGEARR VQVAKEKTTV IGGKGSKETI QKHLDLLNGR
360 370 380 390 400
LKQTTEKYDT DLLKERIAHL SQGVAVVRVG GATELAQKEL KLRIEDALNS
410 420 430 440 450
TKAAVEEGII SGGGIALLNV STILNDSKLA DKYKAETSAE NLKEILVGYE
460 470 480 490 500
IVRKSLEAPV RQIIENSGVN PVKVFAELRS EADGVGFDAE TKKKVDMIRS
510 520 530 540
GIIDPTKVTK TALEKAASVA SSLITTSVAV YDIKENKEGS FQE
Length:543
Mass (Da):58,086
Last modified:February 1, 1997 - v1
Checksum:i74310494DD99A5C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95917.1.
PIRiS73595.
RefSeqiNP_110262.1. NC_000912.1.
WP_010874930.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95917; AAB95917; MPN_573.
GeneIDi876804.
KEGGimpn:MPN573.
PATRICifig|272634.6.peg.635.

Similar proteinsi

Entry informationi

Entry nameiCH60_MYCPN
AccessioniPrimary (citable) accession number: P78012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families