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P78011

- GLYA_MYCPN

UniProt

P78011 - GLYA_MYCPN

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Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Pyridoxal phosphateUniRule annotation
Binding sitei45 – 451Pyridoxal phosphateUniRule annotation
Binding sitei47 – 471SubstrateUniRule annotation
Binding sitei54 – 541SubstrateUniRule annotation
Binding sitei55 – 551Pyridoxal phosphateUniRule annotation
Binding sitei89 – 891Pyridoxal phosphateUniRule annotation
Binding sitei111 – 1111Substrate; via carbonyl oxygenUniRule annotation
Binding sitei166 – 1661Pyridoxal phosphateUniRule annotation
Binding sitei194 – 1941Pyridoxal phosphateUniRule annotation
Binding sitei219 – 2191Pyridoxal phosphateUniRule annotation
Binding sitei226 – 2261Pyridoxal phosphateUniRule annotation
Binding sitei252 – 2521Pyridoxal phosphate; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei348 – 3481Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-581.
MPNE272634:GJ6Z-622-MONOMER.
UniPathwayiUPA00193.
UPA00288; UER01023.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.1UniRule annotation)
Short name:
SHMTUniRule annotation
Short name:
Serine methylaseUniRule annotation
Gene namesi
Name:glyAUniRule annotation
Ordered Locus Names:MPN_576
ORF Names:MP266
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Serine hydroxymethyltransferasePRO_0000113616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiP78011.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272634.MPN576.

Structurei

3D structure databases

ProteinModelPortaliP78011.
SMRiP78011. Positions 2-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1173Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the SHMT family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0112.
KOiK00600.
OMAiHLMLVDV.
OrthoDBiEOG6Z0QB2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78011-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPKIRRILN KELQRQRDCI CLIASENYVS RDILEVTGSI LTNKYAEGYP
60 70 80 90 100
TRRFYEGCEV VDESESLAIN TCKELFGAKW ANVQPHSGSS ANYAVYLALL
110 120 130 140 150
KPGDAILGLD LNCGGHLTHG NKFNFSGKQY QPYSYTINPE TEMLDYDEVL
160 170 180 190 200
RVAREVKPKL IICGFSNYSR TVDFERFSAI AKEVGAYLLA DIAHIAGLVA
210 220 230 240 250
AGLHPNPLPY TDVVTSTTHK TLRGPRGGLI MSNNEAIIRK LDSGVFPGCQ
260 270 280 290 300
GGPLQHVIAA KYVCFKEALQ PKYKQYIQNV KTNAASMASW FKQQGYRVIS
310 320 330 340 350
NGTDTHLFSL DVGKGKDVSQ WLQQANIVLN MNTVPFDKNP AINPSGIRIG
360 370 380 390 400
TPAMTTRGFK EKHFLYVAAL IDKIIKSDGN KKVIKEVKKA VLKLLERFPL

YKGLEY
Length:406
Mass (Da):45,266
Last modified:February 1, 1997 - v1
Checksum:i0460FEA4F730E356
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95914.1.
PIRiS73592.
RefSeqiNP_110265.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95914; AAB95914; MPN_576.
GeneIDi876801.
KEGGimpn:MPN576.
PATRICi20022631. VBIMycPne110_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95914.1 .
PIRi S73592.
RefSeqi NP_110265.1. NC_000912.1.

3D structure databases

ProteinModelPortali P78011.
SMRi P78011. Positions 2-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN576.

Proteomic databases

PaxDbi P78011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95914 ; AAB95914 ; MPN_576 .
GeneIDi 876801.
KEGGi mpn:MPN576.
PATRICi 20022631. VBIMycPne110_0638.

Phylogenomic databases

eggNOGi COG0112.
KOi K00600.
OMAi HLMLVDV.
OrthoDBi EOG6Z0QB2.

Enzyme and pathway databases

UniPathwayi UPA00193 .
UPA00288 ; UER01023 .
BioCyci MetaCyc:MONOMER-581.
MPNE272634:GJ6Z-622-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00051. SHMT.
InterProi IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view ]
PANTHERi PTHR11680. PTHR11680. 1 hit.
Pfami PF00464. SHMT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000412. SHMT. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00096. SHMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiGLYA_MYCPN
AccessioniPrimary (citable) accession number: P78011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3