Reviewed, UniProtKB/Swiss-Prot P78008 (MTLD_MYCPN)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	MPN_652
ORF Names:	MP190

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170712
Regions
	Nucleotide binding	6 – 17	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	P78008-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 199394BBF11E31B6	FASTA	364	42,271
	10 20 30 40 50 60 MKRINVLHFG AGNIGRGVIL PIYQQNDFSI DLVELNQNTV NELQKQKQYQ VHYLDCDQSQ 70 80 90 100 110 120 LVNDFNTWNL KDEAKIIELM ERADVISTSI GAKNLASLKT LFDKAKFHKR AIVLCFENGF 130 140 150 160 170 180 RISSNFKNIL QLNNTQVNFV DVVIDTIAPN FEKKANFLDI YCEKYSEIYA ETFPLEIKGV 190 200 210 220 230 240 NQKNSLDRFI IKKLLLVNAL HSVIGLLGFQ QKLKYVHETL QVKSNLTFVE KLAQQIIDAL 250 260 270 280 290 300 CAEYPEFNKN NLLSYGKNNL VRFANPKIQD LNTRLIREPL RKLNQNERFY AIYKLFKKNK 310 320 330 340 350 360 IALNNILQVY LMVLKTNITD DTESQQIAKL INEKAWTELA KLSSLEESEW NLIKQELSRE ITKK

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95838.1.
PIR	S73516.
RefSeq	NP_110341.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	877028.
GenomeReviews	Gene locus MPN_652 in contig U00089_GR.
KEGG	mpn:MPN652.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P78008.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-622. MPNE272634:MPN652-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

MTLD_MYCPN

Accession

Primary (citable) accession number: P78008

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 4, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)