Skip Header

Contribute Send feedback
Read comments (?) or add your own

P78007 (LDH_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase
Short name=L-LDH
EC=1.1.1.27
Gene names
Name:ldh
Ordered Locus Names:MPN_674
ORF Names:MP168
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP-Rule MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP-Rule MF_00488

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312L-lactate dehydrogenase HAMAP-Rule MF_00488
PRO_0000168374

Regions

Nucleotide binding12 – 4029NAD By similarity

Sites

Active site1771Proton acceptor By similarity
Binding site901Substrate By similarity
Binding site1221NAD or substrate By similarity
Binding site1531Substrate By similarity
Binding site2291Substrate By similarity

Amino acid modifications

Modified residue2201Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P78007 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 604F58CD3B6C273A

FASTA31233,888
        10         20         30         40         50         60 
MKSLKVALIG SGAVGTSFLY AAMSRGLASE YMVIDINEKS QVGNVFDLQD AVPSSPQYSK 

        70         80         90        100        110        120 
VIAGDYKQLK DYDFIFIGAG RPQKQGGETR LQLLEGNVEI MKNIAKAVKE SGFKGITLIA 

       130        140        150        160        170        180 
SNPVDIMAYT YLKVTGFEPN KVIGSGTLLD SARLKFAIAE KYGMSSRDVQ AYVLGEHGDS 

       190        200        210        220        230        240 
SVSIISSAKI AGLPLKHFSK ASDIEKEFAE IDHFIRRRAY EIIERKGATF YGIGEATAEV 

       250        260        270        280        290        300 
AELILRDTKE VRVVASLING QYGAKDVMFG TPCVLGRNGV EKILEIELSA TEKAGLDKSI 

       310 
QVLKDNIKLA KL

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00089 Genomic DNA. Translation: AAB95816.1.
PIRS73494.
RefSeqNP_110363.1. NC_000912.1.

3D structure databases

ProteinModelPortalP78007.
ModBaseSearch...

Protein-protein interaction databases

IntActP78007. 6 interactions.
STRING272634.MPN674.

Proteomic databases

PaxDbP78007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95816; AAB95816; MPN_674.
GeneID877032.
KEGGmpn:MPN674.
PATRIC20022837. VBIMycPne110_0741.

Phylogenomic databases

eggNOGCOG0039.
KOK00016.
OMADVASDKL.
ProtClustDBCLSK335359.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-601.
MPNE272634:GJ6Z-720-MONOMER.
UniPathwayUPA00554; UER00611.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00488. Lactate_dehydrog.
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PTHR11540:SF3. PTHR11540:SF3. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDH_MYCPN
AccessionPrimary (citable) accession number: P78007
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents