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P77989

- BGAL_THEP3

UniProt

P77989 - BGAL_THEP3

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Protein

Beta-galactosidase

Gene
lacZ, lacA, Teth39_0611
Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei388 – 3881Proton donor By similarity
Active sitei453 – 4531Nucleophile By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciTPSE340099:GH4W-632-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Synonyms:lacA
Ordered Locus Names:Teth39_0611
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002156: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Beta-galactosidasePRO_0000057677Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340099.Teth39_0611.

Structurei

3D structure databases

ProteinModelPortaliP77989.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000253353.
KOiK01190.
OMAiINESQDN.
OrthoDBiEOG6H7FBN.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
2.60.40.920. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR003344. Big_1.
IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49373. SSF49373. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77989-1 [UniParc]FASTAAdd to Basket

« Hide

MGRDVLNFNV DWLYIPEDLN DAYKFDFDES NFEVVSLPHA NKTFPHHYFK    50
EEDYRFVSWY RKHFKVDERY KGKKVYIHFE GVITVAKVYV NGEFVGEHKG 100
GYTPFEFDIT EYIKYGNFEN LIAVQVDSRE HKDIPPEGHL VDYMLFGGIY 150
RNVWLKILND THIKDVYFVV DKLQDSVAEI SITTTIAGKE ISNGKILTEV 200
INKEGVVCSS VVTDIKEMQK EIVQQIKMDN PLTWHPDHPY LYNVSVKLIA 250
ENEILDNYTF KTGIRTVEFR DDGKFYINGE PLKLRGLNRH QTFPYVGGAM 300
PDRVQRKDAD ILKYELGLNY VRTSHYPQAV SFLDRCDEIG LLVFEEIPGW 350
QHIGDENWKN IAKENLKEMI LRDRNHPCIF MWGVRINESL DDHDFYKEMN 400
EIAHKLDRSR PTGGVRYLRD SEKLEDVFTY NDFIYNLEGK IQLPNHKKYM 450
VTEYMGHMYP TKSYDNLNRL ITHARLHALI QDKQYGIPNM AGASGWCAFD 500
YNTTSAFGSG DNICYHGVCD IFRLPKFAAH FYRSQADPHL YGPYVFIASY 550
LIPSFEEENG DKLLVFSNCE EVELYINDKF VKRQMPNRVD FPSLPHPPFE 600
FSMKECGINY MEVRVNNASI TAIGLIDGKE VARHTLRPYG KPHKLILSCD 650
DNEIMADGAD CTRVVVSVVD ENGSILPYAN IPVSFEIEGE GKLIGENPLT 700
LEAGRGAVYV KSTRKPGEII LKAKSHYVAE ESNVSIKTKS IGY 743
Length:743
Mass (Da):85,765
Last modified:May 20, 2008 - v2
Checksum:iA803F29C65B73A5A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541Y → H in CAA69850. 1 Publication
Sequence conflicti84 – 874TVAK → LLR in CAA69850. 1 Publication
Sequence conflicti265 – 2651R → KG in CAA69850. 1 Publication
Sequence conflicti341 – 3411L → M in CAA69850. 1 Publication
Sequence conflicti389 – 3891S → R in CAA69850. 1 Publication
Sequence conflicti609 – 6091N → S in CAA69850. 1 Publication
Sequence conflicti618 – 6181A → S in CAA69850. 1 Publication
Sequence conflicti623 – 6231I → V in CAA69850. 1 Publication
Sequence conflicti648 – 6492SC → TA in CAA69850. 1 Publication
Sequence conflicti652 – 6521N → V in CAA69850. 1 Publication
Sequence conflicti659 – 6591A → S in CAA69850. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08557 Genomic DNA. Translation: CAA69850.1.
CP000924 Genomic DNA. Translation: ABY94275.1.
RefSeqiYP_001664611.1. NC_010321.1.

Genome annotation databases

EnsemblBacteriaiABY94275; ABY94275; Teth39_0611.
GeneIDi5873913.
KEGGitpd:Teth39_0611.
PATRICi23885832. VBIThePse6203_0640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08557 Genomic DNA. Translation: CAA69850.1 .
CP000924 Genomic DNA. Translation: ABY94275.1 .
RefSeqi YP_001664611.1. NC_010321.1.

3D structure databases

ProteinModelPortali P77989.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340099.Teth39_0611.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY94275 ; ABY94275 ; Teth39_0611 .
GeneIDi 5873913.
KEGGi tpd:Teth39_0611.
PATRICi 23885832. VBIThePse6203_0640.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000253353.
KOi K01190.
OMAi INESQDN.
OrthoDBi EOG6H7FBN.

Enzyme and pathway databases

BioCyci TPSE340099:GH4W-632-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
2.60.40.920. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR003344. Big_1.
IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49373. SSF49373. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zverlov V.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33223 / 39E.

Entry informationi

Entry nameiBGAL_THEP3
AccessioniPrimary (citable) accession number: P77989
Secondary accession number(s): B0K7M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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