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P77989

- BGAL_THEP3

UniProt

P77989 - BGAL_THEP3

Protein

Beta-galactosidase

Gene

lacZ

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei388 – 3881Proton donorBy similarity
    Active sitei453 – 4531NucleophileBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciTPSE340099:GH4W-632-MONOMER.

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Short name:
    Beta-gal
    Alternative name(s):
    Lactase
    Gene namesi
    Name:lacZ
    Synonyms:lacA
    Ordered Locus Names:Teth39_0611
    OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
    Taxonomic identifieri340099 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002156: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 743743Beta-galactosidasePRO_0000057677Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340099.Teth39_0611.

    Structurei

    3D structure databases

    ProteinModelPortaliP77989.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000253353.
    KOiK01190.
    OMAiINESQDN.
    OrthoDBiEOG6H7FBN.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    2.60.40.920. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR003344. Big_1.
    IPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR008964. Invasin/intimin_cell_adhesion.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SUPFAMiSSF49303. SSF49303. 1 hit.
    SSF49373. SSF49373. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P77989-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRDVLNFNV DWLYIPEDLN DAYKFDFDES NFEVVSLPHA NKTFPHHYFK    50
    EEDYRFVSWY RKHFKVDERY KGKKVYIHFE GVITVAKVYV NGEFVGEHKG 100
    GYTPFEFDIT EYIKYGNFEN LIAVQVDSRE HKDIPPEGHL VDYMLFGGIY 150
    RNVWLKILND THIKDVYFVV DKLQDSVAEI SITTTIAGKE ISNGKILTEV 200
    INKEGVVCSS VVTDIKEMQK EIVQQIKMDN PLTWHPDHPY LYNVSVKLIA 250
    ENEILDNYTF KTGIRTVEFR DDGKFYINGE PLKLRGLNRH QTFPYVGGAM 300
    PDRVQRKDAD ILKYELGLNY VRTSHYPQAV SFLDRCDEIG LLVFEEIPGW 350
    QHIGDENWKN IAKENLKEMI LRDRNHPCIF MWGVRINESL DDHDFYKEMN 400
    EIAHKLDRSR PTGGVRYLRD SEKLEDVFTY NDFIYNLEGK IQLPNHKKYM 450
    VTEYMGHMYP TKSYDNLNRL ITHARLHALI QDKQYGIPNM AGASGWCAFD 500
    YNTTSAFGSG DNICYHGVCD IFRLPKFAAH FYRSQADPHL YGPYVFIASY 550
    LIPSFEEENG DKLLVFSNCE EVELYINDKF VKRQMPNRVD FPSLPHPPFE 600
    FSMKECGINY MEVRVNNASI TAIGLIDGKE VARHTLRPYG KPHKLILSCD 650
    DNEIMADGAD CTRVVVSVVD ENGSILPYAN IPVSFEIEGE GKLIGENPLT 700
    LEAGRGAVYV KSTRKPGEII LKAKSHYVAE ESNVSIKTKS IGY 743
    Length:743
    Mass (Da):85,765
    Last modified:May 20, 2008 - v2
    Checksum:iA803F29C65B73A5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541Y → H in CAA69850. 1 PublicationCurated
    Sequence conflicti84 – 874TVAK → LLR in CAA69850. 1 PublicationCurated
    Sequence conflicti265 – 2651R → KG in CAA69850. 1 PublicationCurated
    Sequence conflicti341 – 3411L → M in CAA69850. 1 PublicationCurated
    Sequence conflicti389 – 3891S → R in CAA69850. 1 PublicationCurated
    Sequence conflicti609 – 6091N → S in CAA69850. 1 PublicationCurated
    Sequence conflicti618 – 6181A → S in CAA69850. 1 PublicationCurated
    Sequence conflicti623 – 6231I → V in CAA69850. 1 PublicationCurated
    Sequence conflicti648 – 6492SC → TA in CAA69850. 1 PublicationCurated
    Sequence conflicti652 – 6521N → V in CAA69850. 1 PublicationCurated
    Sequence conflicti659 – 6591A → S in CAA69850. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08557 Genomic DNA. Translation: CAA69850.1.
    CP000924 Genomic DNA. Translation: ABY94275.1.
    RefSeqiYP_001664611.1. NC_010321.1.

    Genome annotation databases

    EnsemblBacteriaiABY94275; ABY94275; Teth39_0611.
    GeneIDi5873913.
    KEGGitpd:Teth39_0611.
    PATRICi23885832. VBIThePse6203_0640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08557 Genomic DNA. Translation: CAA69850.1 .
    CP000924 Genomic DNA. Translation: ABY94275.1 .
    RefSeqi YP_001664611.1. NC_010321.1.

    3D structure databases

    ProteinModelPortali P77989.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340099.Teth39_0611.

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY94275 ; ABY94275 ; Teth39_0611 .
    GeneIDi 5873913.
    KEGGi tpd:Teth39_0611.
    PATRICi 23885832. VBIThePse6203_0640.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000253353.
    KOi K01190.
    OMAi INESQDN.
    OrthoDBi EOG6H7FBN.

    Enzyme and pathway databases

    BioCyci TPSE340099:GH4W-632-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    2.60.40.920. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR003344. Big_1.
    IPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR008964. Invasin/intimin_cell_adhesion.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SUPFAMi SSF49303. SSF49303. 1 hit.
    SSF49373. SSF49373. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zverlov V.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33223 / 39E.

    Entry informationi

    Entry nameiBGAL_THEP3
    AccessioniPrimary (citable) accession number: P77989
    Secondary accession number(s): B0K7M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3