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P77989 (BGAL_THEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-galactosidase

Short name=Beta-gal
EC=3.2.1.23
Alternative name(s):
Lactase
Gene names
Name:lacZ
Synonyms:lacA
Ordered Locus Names:Teth39_0611
OrganismThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum) [Complete proteome] [HAMAP]
Taxonomic identifier340099 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 743743Beta-galactosidase
PRO_0000057677

Sites

Active site3881Proton donor By similarity
Active site4531Nucleophile By similarity

Experimental info

Sequence conflict541Y → H in CAA69850. Ref.1
Sequence conflict84 – 874TVAK → LLR in CAA69850. Ref.1
Sequence conflict2651R → KG in CAA69850. Ref.1
Sequence conflict3411L → M in CAA69850. Ref.1
Sequence conflict3891S → R in CAA69850. Ref.1
Sequence conflict6091N → S in CAA69850. Ref.1
Sequence conflict6181A → S in CAA69850. Ref.1
Sequence conflict6231I → V in CAA69850. Ref.1
Sequence conflict648 – 6492SC → TA in CAA69850. Ref.1
Sequence conflict6521N → V in CAA69850. Ref.1
Sequence conflict6591A → S in CAA69850. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P77989 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: A803F29C65B73A5A

FASTA74385,765
        10         20         30         40         50         60 
MGRDVLNFNV DWLYIPEDLN DAYKFDFDES NFEVVSLPHA NKTFPHHYFK EEDYRFVSWY 

        70         80         90        100        110        120 
RKHFKVDERY KGKKVYIHFE GVITVAKVYV NGEFVGEHKG GYTPFEFDIT EYIKYGNFEN 

       130        140        150        160        170        180 
LIAVQVDSRE HKDIPPEGHL VDYMLFGGIY RNVWLKILND THIKDVYFVV DKLQDSVAEI 

       190        200        210        220        230        240 
SITTTIAGKE ISNGKILTEV INKEGVVCSS VVTDIKEMQK EIVQQIKMDN PLTWHPDHPY 

       250        260        270        280        290        300 
LYNVSVKLIA ENEILDNYTF KTGIRTVEFR DDGKFYINGE PLKLRGLNRH QTFPYVGGAM 

       310        320        330        340        350        360 
PDRVQRKDAD ILKYELGLNY VRTSHYPQAV SFLDRCDEIG LLVFEEIPGW QHIGDENWKN 

       370        380        390        400        410        420 
IAKENLKEMI LRDRNHPCIF MWGVRINESL DDHDFYKEMN EIAHKLDRSR PTGGVRYLRD 

       430        440        450        460        470        480 
SEKLEDVFTY NDFIYNLEGK IQLPNHKKYM VTEYMGHMYP TKSYDNLNRL ITHARLHALI 

       490        500        510        520        530        540 
QDKQYGIPNM AGASGWCAFD YNTTSAFGSG DNICYHGVCD IFRLPKFAAH FYRSQADPHL 

       550        560        570        580        590        600 
YGPYVFIASY LIPSFEEENG DKLLVFSNCE EVELYINDKF VKRQMPNRVD FPSLPHPPFE 

       610        620        630        640        650        660 
FSMKECGINY MEVRVNNASI TAIGLIDGKE VARHTLRPYG KPHKLILSCD DNEIMADGAD 

       670        680        690        700        710        720 
CTRVVVSVVD ENGSILPYAN IPVSFEIEGE GKLIGENPLT LEAGRGAVYV KSTRKPGEII 

       730        740 
LKAKSHYVAE ESNVSIKTKS IGY 

« Hide

References

« Hide 'large scale' references
[1]Zverlov V.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33223 / 39E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08557 Genomic DNA. Translation: CAA69850.1.
CP000924 Genomic DNA. Translation: ABY94275.1.
RefSeqYP_001664611.1. NC_010321.1.

3D structure databases

ProteinModelPortalP77989.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340099.Teth39_0611.

Protein family/group databases

CAZyGH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY94275; ABY94275; Teth39_0611.
GeneID5873913.
KEGGtpd:Teth39_0611.
PATRIC23885832. VBIThePse6203_0640.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3250.
HOGENOMHOG000253353.
KOK01190.
OMAKFAAYAY.
OrthoDBEOG6H7FBN.
ProtClustDBCLSK892039.

Enzyme and pathway databases

BioCycTPSE340099:GH4W-632-MONOMER.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
2.60.40.920. 1 hit.
3.20.20.80. 1 hit.
InterProIPR003344. Big_1.
IPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR008964. Invasin/intimin_cell_adhesion.
[Graphical view]
PfamPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSPR00132. GLHYDRLASE2.
SUPFAMSSF49303. SSF49303. 1 hit.
SSF49373. SSF49373. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGAL_THEP3
AccessionPrimary (citable) accession number: P77989
Secondary accession number(s): B0K7M6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 20, 2008
Last modified: November 13, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries