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Protein
Submitted name:

Cyt P-450-9-deoxo-FK506 hydroxylase e

Gene

fkbD

Organism
Streptomyces sp.
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotationSAAS annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cyt P-450-9-deoxo-FK506 hydroxylase eImported
Gene namesi
Name:fkbDImported
OrganismiStreptomyces sp.Imported
Taxonomic identifieri1931 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Structurei

3D structure databases

ProteinModelPortaliP77977.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDTPAGTP QAGRCPFAIQ DAHRAILDSA TVGSFDLFGI KHWLVAAAED
60 70 80 90 100
VKLVTNDPRF SSAAPSEMLP DRRPGWFSGM DVPEHSRYRQ KIAGDFTLRA
110 120 130 140 150
ARRQEEFVFE AADACLDEIE AAGPGADLVP GYAKRLPSLV INALYGLTPE
160 170 180 190 200
EGAVLETRMR GITGSTDLDS VKTLTDDFFA HALELVRAKR DERGDDLLHR
210 220 230 240 250
LASAEDGEIP LSDDEATGVF ATLLFAGHDS VQQMVGYCLY ALLSHPEQEG
260 270 280 290 300
ALRTRPELID GAVEEMLRFL PVNQMGVPRV CVADVDLRGV RISVGDNVIP
310 320 330 340 350
LYSTANRDPE VFPDPDTFDV SRPTEGNFAF GHGVHKCPGQ HVARLLIKVA
360 370 380
CLRLLERFPD VRLVGDVPMN EGLGLFSPAE LRITWGAA
Length:388
Mass (Da):42,305
Last modified:February 1, 1997 - v1
Checksum:i513A7D03C50D414C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65940 Genomic DNA. Translation: AAC44359.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65940 Genomic DNA. Translation: AAC44359.1.

3D structure databases

ProteinModelPortaliP77977.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520."
    Motamedi H., Shafiee A., Cai S.J., Streicher S.L., Arison B.H., Miller R.R.
    J. Bacteriol. 178:5243-5248(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MA6858Imported.

Entry informationi

Entry nameiP77977_STRSQ
AccessioniPrimary (citable) accession number: P77977
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.