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Protein

Cryptochrome DASH

Gene

cry

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a photoreceptor function. Binds DNA; represses transcription of at least 8 genes, including slr0364 and slr1866. Does not encode a DNA photolyase function. Its disruption does not affect circadian rhythm.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Chromophore, DNA-binding, FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptochrome DASH
Gene namesi
Name:cry
Synonyms:phr, phrB
Ordered Locus Names:sll1629
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Pathology & Biotechi

Chemistry

DrugBankiDB03147. Flavin adenine dinucleotide.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cryptochrome DASHPRO_0000235311Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP77967. 3 interactions.

Structurei

Secondary structure

1
489
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 148Combined sources
Helixi22 – 298Combined sources
Beta strandi32 – 409Combined sources
Helixi42 – 454Combined sources
Beta strandi53 – 553Combined sources
Helixi57 – 7620Combined sources
Beta strandi81 – 866Combined sources
Helixi88 – 9811Combined sources
Beta strandi101 – 1077Combined sources
Helixi112 – 12817Combined sources
Beta strandi131 – 1355Combined sources
Beta strandi138 – 1414Combined sources
Helixi143 – 1453Combined sources
Beta strandi146 – 1483Combined sources
Helixi150 – 1523Combined sources
Helixi157 – 1659Combined sources
Turni166 – 1683Combined sources
Helixi196 – 1983Combined sources
Helixi216 – 22712Combined sources
Helixi233 – 2353Combined sources
Helixi236 – 2394Combined sources
Beta strandi244 – 2463Combined sources
Helixi253 – 2575Combined sources
Helixi263 – 27614Combined sources
Helixi281 – 30323Combined sources
Helixi304 – 3085Combined sources
Turni310 – 3156Combined sources
Helixi324 – 3318Combined sources
Helixi338 – 35013Combined sources
Helixi355 – 36713Combined sources
Helixi373 – 38311Combined sources
Helixi389 – 39911Combined sources
Helixi414 – 4218Combined sources
Helixi426 – 4316Combined sources
Helixi433 – 4353Combined sources
Helixi441 – 4444Combined sources
Helixi446 – 4483Combined sources
Helixi451 – 4566Combined sources
Turni461 – 4633Combined sources
Helixi472 – 4809Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NP7X-ray1.90A/B1-489[»]
ProteinModelPortaliP77967.
SMRiP77967. Positions 1-483.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77967.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 140135Photolyase/cryptochrome alpha/betaAdd
BLAST

Sequence similaritiesi

Belongs to the DNA photolyase class-1 family.Curated

Phylogenomic databases

HOGENOMiHOG000245621.
InParanoidiP77967.
KOiK01669.
OMAiTYWLIFE.
PhylomeDBiP77967.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR014133. Cry_DASH.
IPR005101. Cryptochr/Photolyase_FAD-bd.
IPR002081. Cryptochrome/DNA_photolyase_1.
IPR018394. DNA_photolyase_1_CS_C.
IPR006050. DNA_photolyase_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR11455:SF22. PTHR11455:SF22. 1 hit.
PfamiPF00875. DNA_photolyase. 1 hit.
PF03441. FAD_binding_7. 1 hit.
[Graphical view]
PRINTSiPR00147. DNAPHOTLYASE.
SUPFAMiSSF48173. SSF48173. 1 hit.
SSF52425. SSF52425. 1 hit.
TIGRFAMsiTIGR02765. crypto_DASH. 1 hit.
PROSITEiPS00394. DNA_PHOTOLYASES_1_1. 1 hit.
PS51645. PHR_CRY_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHVPPTVLV WFRNDLRLHD HEPLHRALKS GLAITAVYCY DPRQFAQTHQ
60 70 80 90 100
GFAKTGPWRS NFLQQSVQNL AESLQKVGNK LLVTTGLPEQ VIPQIAKQIN
110 120 130 140 150
AKTIYYHREV TQEELDVERN LVKQLTILGI EAKGYWGSTL CHPEDLPFSI
160 170 180 190 200
QDLPDLFTKF RKDIEKKKIS IRPCFFAPSQ LLPSPNIKLE LTAPPPEFFP
210 220 230 240 250
QINFDHRSVL AFQGGETAGL ARLQDYFWHG DRLKDYKETR NGMVGADYSS
260 270 280 290 300
KFSPWLALGC LSPRFIYQEV KRYEQERVSN DSTHWLIFEL LWRDFFRFVA
310 320 330 340 350
QKYGNKLFNR GGLLNKNFPW QEDQVRFELW RSGQTGYPLV DANMRELNLT
360 370 380 390 400
GFMSNRGRQN VASFLCKNLG IDWRWGAEWF ESCLIDYDVC SNWGNWNYTA
410 420 430 440 450
GIGNDARDFR YFNIPKQSQQ YDPQGTYLRH WLPELKNLPG DKIHQPWLLS
460 470 480
ATEQKQWGVQ LGVDYPRPCV NFHQSVEARR KIEQMGVIA
Length:489
Mass (Da):57,040
Last modified:May 16, 2006 - v2
Checksum:i11CA917E34F0BAD0
GO

Sequence cautioni

The sequence BAA17766 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17766.1. Different initiation.
PIRiS74805.

Genome annotation databases

EnsemblBacteriaiBAA17766; BAA17766; BAA17766.
KEGGisyn:sll1629.
PATRICi23839466. VBISynSp132158_1297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17766.1. Different initiation.
PIRiS74805.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NP7X-ray1.90A/B1-489[»]
ProteinModelPortaliP77967.
SMRiP77967. Positions 1-483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP77967. 3 interactions.

Chemistry

DrugBankiDB03147. Flavin adenine dinucleotide.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17766; BAA17766; BAA17766.
KEGGisyn:sll1629.
PATRICi23839466. VBISynSp132158_1297.

Phylogenomic databases

HOGENOMiHOG000245621.
InParanoidiP77967.
KOiK01669.
OMAiTYWLIFE.
PhylomeDBiP77967.

Miscellaneous databases

EvolutionaryTraceiP77967.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR014133. Cry_DASH.
IPR005101. Cryptochr/Photolyase_FAD-bd.
IPR002081. Cryptochrome/DNA_photolyase_1.
IPR018394. DNA_photolyase_1_CS_C.
IPR006050. DNA_photolyase_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR11455:SF22. PTHR11455:SF22. 1 hit.
PfamiPF00875. DNA_photolyase. 1 hit.
PF03441. FAD_binding_7. 1 hit.
[Graphical view]
PRINTSiPR00147. DNAPHOTLYASE.
SUPFAMiSSF48173. SSF48173. 1 hit.
SSF52425. SSF52425. 1 hit.
TIGRFAMsiTIGR02765. crypto_DASH. 1 hit.
PROSITEiPS00394. DNA_PHOTOLYASES_1_1. 1 hit.
PS51645. PHR_CRY_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRYD_SYNY3
AccessioniPrimary (citable) accession number: P77967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.