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Protein

Cryptochrome DASH

Gene

cry

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a photoreceptor function. Binds DNA; represses transcription of at least 8 genes, including slr0364 and slr1866. Does not encode a DNA photolyase function. Its disruption does not affect circadian rhythm.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandChromophore, FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptochrome DASH
Gene namesi
Name:cry
Synonyms:phr, phrB
Ordered Locus Names:sll1629
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB03147 Flavin adenine dinucleotide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353111 – 489Cryptochrome DASHAdd BLAST489

Proteomic databases

PaxDbiP77967
PRIDEiP77967

Interactioni

Protein-protein interaction databases

IntActiP77967, 3 interactors
STRINGi1148.SYNGTS_1190

Structurei

Secondary structure

1489
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 40Combined sources3
Helixi42 – 45Combined sources4
Beta strandi53 – 55Combined sources3
Helixi57 – 76Combined sources20
Beta strandi81 – 86Combined sources6
Helixi88 – 98Combined sources11
Beta strandi101 – 107Combined sources7
Helixi112 – 128Combined sources17
Beta strandi131 – 135Combined sources5
Beta strandi138 – 141Combined sources4
Helixi143 – 145Combined sources3
Beta strandi146 – 148Combined sources3
Helixi150 – 152Combined sources3
Helixi157 – 165Combined sources9
Turni166 – 168Combined sources3
Helixi196 – 198Combined sources3
Helixi216 – 227Combined sources12
Helixi233 – 235Combined sources3
Helixi236 – 239Combined sources4
Beta strandi244 – 246Combined sources3
Helixi253 – 257Combined sources5
Helixi263 – 276Combined sources14
Helixi281 – 303Combined sources23
Helixi304 – 308Combined sources5
Turni310 – 315Combined sources6
Helixi324 – 331Combined sources8
Helixi338 – 350Combined sources13
Helixi355 – 367Combined sources13
Helixi373 – 383Combined sources11
Helixi389 – 399Combined sources11
Helixi414 – 421Combined sources8
Helixi426 – 431Combined sources6
Helixi433 – 435Combined sources3
Helixi441 – 444Combined sources4
Helixi446 – 448Combined sources3
Helixi451 – 456Combined sources6
Turni461 – 463Combined sources3
Helixi472 – 480Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NP7X-ray1.90A/B1-489[»]
ProteinModelPortaliP77967
SMRiP77967
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77967

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 140Photolyase/cryptochrome alpha/betaAdd BLAST135

Sequence similaritiesi

Belongs to the DNA photolyase class-1 family.Curated

Phylogenomic databases

HOGENOMiHOG000245621
InParanoidiP77967
KOiK01669
OMAiIDYDVCS
PhylomeDBiP77967

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR014133 Cry_DASH
IPR036134 Crypto/Photolyase_FAD-like_sf
IPR036155 Crypto/Photolyase_N_sf
IPR005101 Cryptochr/Photolyase_FAD-bd
IPR002081 Cryptochrome/DNA_photolyase_1
IPR018394 DNA_photolyase_1_CS_C
IPR006050 DNA_photolyase_N
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00875 DNA_photolyase, 1 hit
PF03441 FAD_binding_7, 1 hit
PRINTSiPR00147 DNAPHOTLYASE
SUPFAMiSSF48173 SSF48173, 1 hit
SSF52425 SSF52425, 1 hit
TIGRFAMsiTIGR02765 crypto_DASH, 1 hit
PROSITEiView protein in PROSITE
PS00394 DNA_PHOTOLYASES_1_1, 1 hit
PS51645 PHR_CRY_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P77967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHVPPTVLV WFRNDLRLHD HEPLHRALKS GLAITAVYCY DPRQFAQTHQ
60 70 80 90 100
GFAKTGPWRS NFLQQSVQNL AESLQKVGNK LLVTTGLPEQ VIPQIAKQIN
110 120 130 140 150
AKTIYYHREV TQEELDVERN LVKQLTILGI EAKGYWGSTL CHPEDLPFSI
160 170 180 190 200
QDLPDLFTKF RKDIEKKKIS IRPCFFAPSQ LLPSPNIKLE LTAPPPEFFP
210 220 230 240 250
QINFDHRSVL AFQGGETAGL ARLQDYFWHG DRLKDYKETR NGMVGADYSS
260 270 280 290 300
KFSPWLALGC LSPRFIYQEV KRYEQERVSN DSTHWLIFEL LWRDFFRFVA
310 320 330 340 350
QKYGNKLFNR GGLLNKNFPW QEDQVRFELW RSGQTGYPLV DANMRELNLT
360 370 380 390 400
GFMSNRGRQN VASFLCKNLG IDWRWGAEWF ESCLIDYDVC SNWGNWNYTA
410 420 430 440 450
GIGNDARDFR YFNIPKQSQQ YDPQGTYLRH WLPELKNLPG DKIHQPWLLS
460 470 480
ATEQKQWGVQ LGVDYPRPCV NFHQSVEARR KIEQMGVIA
Length:489
Mass (Da):57,040
Last modified:May 16, 2006 - v2
Checksum:i11CA917E34F0BAD0
GO

Sequence cautioni

The sequence BAA17766 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17766.1 Different initiation.
PIRiS74805

Genome annotation databases

EnsemblBacteriaiBAA17766; BAA17766; BAA17766
KEGGisyn:sll1629

Similar proteinsi

Entry informationi

Entry nameiCRYD_SYNY3
AccessioniPrimary (citable) accession number: P77967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names
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