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P77958

- GLNA1_STRFL

UniProt

P77958 - GLNA1_STRFL

Protein

Glutamine synthetase 1

Gene

glnA

Organism
Streptomyces filamentosus (Streptomyces roseosporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase 1 (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase I
    Glutamine synthetase I
    Short name:
    GSI
    Gene namesi
    Name:glnA
    OrganismiStreptomyces filamentosus (Streptomyces roseosporus)
    Taxonomic identifieri67294 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Glutamine synthetase 1PRO_0000153268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei397 – 3971O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP77958.
    SMRiP77958. Positions 3-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR001637. Gln_synth_I_adenylation_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00182. GLNA_ADENYLATION. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P77958-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQNADEVQK YVADNDVKFI DVRFCDLPGV MQHFTIPAAT FDPAEELAFD    50
    GSSIRGFQAI HESDMALRAD LSTARVDPFR RDKTININFF IHDPITGEQY 100
    SRDPRNIAKK AEAYLASTGI ADTAYFGPEA EFYVFDNVRF QTSANESFYH 150
    IDSEAGAWNT GAVENNRGYK VRYKGGYFPA PPVDHFADLR AEISLELDKN 200
    GLQVERQHHE VGTAGQAEIN YKFNTLLAAA DDLMLFKYIV KNVAWRNGKT 250
    ATFMPKPIFG DNGSGMHVHQ SLWQGGSPLF YDEQGYAGLS DTARYYIGGI 300
    LKHAPSLLAF TNPTVNSYHR LVPGFEAPVN MVYSQRNRSA AMRIPITGSN 350
    PKAKRVEFRA PDPSSNPYLA FSALLMAGLD GVKNKIEPAE PIDKDLYELA 400
    PEEHANVQQV PTSLPAVLDA LEADNEYLQA GGVFTSDLIE TWIDYKRTNE 450
    IAPIQLRPHP HEFELYFDI 469
    Length:469
    Mass (Da):52,514
    Last modified:February 1, 1997 - v1
    Checksum:i9AE0FF7A6675F792
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58138 Genomic DNA. Translation: AAB41959.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58138 Genomic DNA. Translation: AAB41959.1 .

    3D structure databases

    ProteinModelPortali P77958.
    SMRi P77958. Positions 3-469.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR001637. Gln_synth_I_adenylation_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00182. GLNA_ADENYLATION. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutants of Streptomyces roseosporus that express enhanced recombination within partially homologous genes."
      Hosted T.J., Baltz R.H.
      Microbiology 142:2803-2813(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A54145.3.

    Entry informationi

    Entry nameiGLNA1_STRFL
    AccessioniPrimary (citable) accession number: P77958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3