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P77958

- GLNA1_STRFL

UniProt

P77958 - GLNA1_STRFL

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Protein

Glutamine synthetase 1

Gene

glnA

Organism
Streptomyces filamentosus (Streptomyces roseosporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase 1 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase I
Glutamine synthetase I
Short name:
GSI
Gene namesi
Name:glnA
OrganismiStreptomyces filamentosus (Streptomyces roseosporus)
Taxonomic identifieri67294 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Glutamine synthetase 1PRO_0000153268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei397 – 3971O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Structurei

3D structure databases

ProteinModelPortaliP77958.
SMRiP77958. Positions 3-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77958-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQNADEVQK YVADNDVKFI DVRFCDLPGV MQHFTIPAAT FDPAEELAFD
60 70 80 90 100
GSSIRGFQAI HESDMALRAD LSTARVDPFR RDKTININFF IHDPITGEQY
110 120 130 140 150
SRDPRNIAKK AEAYLASTGI ADTAYFGPEA EFYVFDNVRF QTSANESFYH
160 170 180 190 200
IDSEAGAWNT GAVENNRGYK VRYKGGYFPA PPVDHFADLR AEISLELDKN
210 220 230 240 250
GLQVERQHHE VGTAGQAEIN YKFNTLLAAA DDLMLFKYIV KNVAWRNGKT
260 270 280 290 300
ATFMPKPIFG DNGSGMHVHQ SLWQGGSPLF YDEQGYAGLS DTARYYIGGI
310 320 330 340 350
LKHAPSLLAF TNPTVNSYHR LVPGFEAPVN MVYSQRNRSA AMRIPITGSN
360 370 380 390 400
PKAKRVEFRA PDPSSNPYLA FSALLMAGLD GVKNKIEPAE PIDKDLYELA
410 420 430 440 450
PEEHANVQQV PTSLPAVLDA LEADNEYLQA GGVFTSDLIE TWIDYKRTNE
460
IAPIQLRPHP HEFELYFDI
Length:469
Mass (Da):52,514
Last modified:February 1, 1997 - v1
Checksum:i9AE0FF7A6675F792
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58138 Genomic DNA. Translation: AAB41959.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58138 Genomic DNA. Translation: AAB41959.1 .

3D structure databases

ProteinModelPortali P77958.
SMRi P77958. Positions 3-469.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mutants of Streptomyces roseosporus that express enhanced recombination within partially homologous genes."
    Hosted T.J., Baltz R.H.
    Microbiology 142:2803-2813(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A54145.3.

Entry informationi

Entry nameiGLNA1_STRFL
AccessioniPrimary (citable) accession number: P77958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3