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P77952

- GLSA_STRGR

UniProt

P77952 - GLSA_STRGR

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Protein

L-glutamine:scyllo-inosose aminotransferase

Gene

stsC

Organism
Streptomyces griseus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the PLP-dependent transamination of scyllo-inosose to form scyllo-inosamine.1 Publication

Catalytic activityi

L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone = 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol.

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi

GO - Molecular functioni

  1. glutamine-scyllo-inositol transaminase activity Source: UniProtKB-EC
  2. L-glutamine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. streptomycin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14011.
UniPathwayiUPA00066.

Names & Taxonomyi

Protein namesi
Recommended name:
L-glutamine:scyllo-inosose aminotransferase (EC:2.6.1.50)
Alternative name(s):
Glutamine--scyllo-inositol transaminase
Gene namesi
Name:stsC
ORF Names:SG7F10.11c
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424L-glutamine:scyllo-inosose aminotransferasePRO_0000233018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP77952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000653. DegT/StrS_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01041. DegT_DnrJ_EryC1. 1 hit.
[Graphical view]
PIRSFiPIRSF000390. PLP_StrS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P77952-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSSLAISGG PRLSNREWPR WPQPGDRALK SLEDVLTSGR WTISCAYQGR
60 70 80 90 100
DSYERQFASA FADYCGSAMC VPISTGTASL AIALEACGVG AGDEVIVPGL
110 120 130 140 150
SWVASASAVL GINAVPVLVD VDPATYCLDP AATEAAITER TRAITVVHAY
160 170 180 190 200
SAVADLDALL DIARRHGLPL IEDCAHAHGA GFRGRPVGAH GAAGVFSMQG
210 220 230 240 250
SKLLTCGEGG ALVTDDADVA LRAEHLRADG RVVRREPVGV GEMELEETGR
260 270 280 290 300
MMGSNACLSE FHAAVLLDQL ELLDGQNARR TRAADHLTDR LSELGMTAQA
310 320 330 340 350
TAPGTTARAY YRYLVRLPDE VLAVAPVERF AHALTAELGF AVTQTHRPLN
360 370 380 390 400
DNPLNRPSSR RRFATDARYL ERVDPSRFDL PAAKRAHESV VSFSHEVLLA
410 420
PLDAIDDIAR AFRKVLDNVR EVSR
Length:424
Mass (Da):45,501
Last modified:February 1, 1997 - v1
Checksum:iAED73E61EA9B0E33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08763 Genomic DNA. Translation: CAA70012.1.
AJ862840 Genomic DNA. Translation: CAH94315.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08763 Genomic DNA. Translation: CAA70012.1 .
AJ862840 Genomic DNA. Translation: CAH94315.1 .

3D structure databases

ProteinModelPortali P77952.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00066 .
BioCyci MetaCyc:MONOMER-14011.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000653. DegT/StrS_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF01041. DegT_DnrJ_EryC1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000390. PLP_StrS. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes."
    Ahlert J., Distler J., Mansouri K., Piepersberg W.
    Arch. Microbiol. 168:102-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CHARACTERIZATION, COFACTOR, SUBUNIT.
    Strain: N2-3-11.
  2. "Cloning and heterologous expression of the str/sts-gene cluster from a Streptomyces griseus DSM40236 PAC library: the cluster for streptomycin production lies in a highly conserved genomic area."
    van der Geize R., Dijkhuizen L., Wellington E.M., Piepersberg W.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 23345 / DSM 40236 / JCM 4644 / NBRC 12875 / NCIMB 13023 / NRRL B-2682 / VKM Ac-800.

Entry informationi

Entry nameiGLSA_STRGR
AccessioniPrimary (citable) accession number: P77952
Secondary accession number(s): Q53IE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3