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P77952

- GLSA_STRGR

UniProt

P77952 - GLSA_STRGR

Protein

L-glutamine:scyllo-inosose aminotransferase

Gene

stsC

Organism
Streptomyces griseus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the PLP-dependent transamination of scyllo-inosose to form scyllo-inosamine.1 Publication

    Catalytic activityi

    L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone = 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol.

    Cofactori

    Pyridoxal phosphate.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. glutamine-scyllo-inositol transaminase activity Source: UniProtKB-EC
    2. L-glutamine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. streptomycin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Antibiotic biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14011.
    UniPathwayiUPA00066.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-glutamine:scyllo-inosose aminotransferase (EC:2.6.1.50)
    Alternative name(s):
    Glutamine--scyllo-inositol transaminase
    Gene namesi
    Name:stsC
    ORF Names:SG7F10.11c
    OrganismiStreptomyces griseus
    Taxonomic identifieri1911 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424L-glutamine:scyllo-inosose aminotransferasePRO_0000233018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei202 – 2021N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP77952.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000653. DegT/StrS_aminotransferase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF01041. DegT_DnrJ_EryC1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000390. PLP_StrS. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P77952-1 [UniParc]FASTAAdd to Basket

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    MDSSLAISGG PRLSNREWPR WPQPGDRALK SLEDVLTSGR WTISCAYQGR    50
    DSYERQFASA FADYCGSAMC VPISTGTASL AIALEACGVG AGDEVIVPGL 100
    SWVASASAVL GINAVPVLVD VDPATYCLDP AATEAAITER TRAITVVHAY 150
    SAVADLDALL DIARRHGLPL IEDCAHAHGA GFRGRPVGAH GAAGVFSMQG 200
    SKLLTCGEGG ALVTDDADVA LRAEHLRADG RVVRREPVGV GEMELEETGR 250
    MMGSNACLSE FHAAVLLDQL ELLDGQNARR TRAADHLTDR LSELGMTAQA 300
    TAPGTTARAY YRYLVRLPDE VLAVAPVERF AHALTAELGF AVTQTHRPLN 350
    DNPLNRPSSR RRFATDARYL ERVDPSRFDL PAAKRAHESV VSFSHEVLLA 400
    PLDAIDDIAR AFRKVLDNVR EVSR 424
    Length:424
    Mass (Da):45,501
    Last modified:February 1, 1997 - v1
    Checksum:iAED73E61EA9B0E33
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08763 Genomic DNA. Translation: CAA70012.1.
    AJ862840 Genomic DNA. Translation: CAH94315.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08763 Genomic DNA. Translation: CAA70012.1 .
    AJ862840 Genomic DNA. Translation: CAH94315.1 .

    3D structure databases

    ProteinModelPortali P77952.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00066 .
    BioCyci MetaCyc:MONOMER-14011.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000653. DegT/StrS_aminotransferase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF01041. DegT_DnrJ_EryC1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000390. PLP_StrS. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes."
      Ahlert J., Distler J., Mansouri K., Piepersberg W.
      Arch. Microbiol. 168:102-113(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CHARACTERIZATION, COFACTOR, SUBUNIT.
      Strain: N2-3-11.
    2. "Cloning and heterologous expression of the str/sts-gene cluster from a Streptomyces griseus DSM40236 PAC library: the cluster for streptomycin production lies in a highly conserved genomic area."
      van der Geize R., Dijkhuizen L., Wellington E.M., Piepersberg W.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 23345 / DSM 40236 / JCM 4644 / NBRC 12875 / NCIMB 13023 / NRRL B-2682 / VKM Ac-800.

    Entry informationi

    Entry nameiGLSA_STRGR
    AccessioniPrimary (citable) accession number: P77952
    Secondary accession number(s): Q53IE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3