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P77952 (GLSA_STRGR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-glutamine:scyllo-inosose aminotransferase

EC=2.6.1.50
Alternative name(s):
Glutamine--scyllo-inositol transaminase
Gene names
Name:stsC
ORF Names:SG7F10.11c
OrganismStreptomyces griseus
Taxonomic identifier1911 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the PLP-dependent transamination of scyllo-inosose to form scyllo-inosamine. Ref.1

Catalytic activity

L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone = 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol.

Cofactor

Pyridoxal phosphate. Ref.1

Pathway

Antibiotic biosynthesis; streptomycin biosynthesis.

Subunit structure

Homodimer. Ref.1

Sequence similarities

Belongs to the DegT/DnrJ/EryC1 family. L-glutamine:2-deoxy-scyllo-inosose/scyllo-inosose aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424L-glutamine:scyllo-inosose aminotransferase
PRO_0000233018

Amino acid modifications

Modified residue2021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P77952 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AED73E61EA9B0E33

FASTA42445,501
        10         20         30         40         50         60 
MDSSLAISGG PRLSNREWPR WPQPGDRALK SLEDVLTSGR WTISCAYQGR DSYERQFASA 

        70         80         90        100        110        120 
FADYCGSAMC VPISTGTASL AIALEACGVG AGDEVIVPGL SWVASASAVL GINAVPVLVD 

       130        140        150        160        170        180 
VDPATYCLDP AATEAAITER TRAITVVHAY SAVADLDALL DIARRHGLPL IEDCAHAHGA 

       190        200        210        220        230        240 
GFRGRPVGAH GAAGVFSMQG SKLLTCGEGG ALVTDDADVA LRAEHLRADG RVVRREPVGV 

       250        260        270        280        290        300 
GEMELEETGR MMGSNACLSE FHAAVLLDQL ELLDGQNARR TRAADHLTDR LSELGMTAQA 

       310        320        330        340        350        360 
TAPGTTARAY YRYLVRLPDE VLAVAPVERF AHALTAELGF AVTQTHRPLN DNPLNRPSSR 

       370        380        390        400        410        420 
RRFATDARYL ERVDPSRFDL PAAKRAHESV VSFSHEVLLA PLDAIDDIAR AFRKVLDNVR 


EVSR 

« Hide

References

[1]"Identification of stsC, the gene encoding the L-glutamine:scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes."
Ahlert J., Distler J., Mansouri K., Piepersberg W.
Arch. Microbiol. 168:102-113(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CHARACTERIZATION, COFACTOR, SUBUNIT.
Strain: N2-3-11.
[2]"Cloning and heterologous expression of the str/sts-gene cluster from a Streptomyces griseus DSM40236 PAC library: the cluster for streptomycin production lies in a highly conserved genomic area."
van der Geize R., Dijkhuizen L., Wellington E.M., Piepersberg W.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 23345 / DSM 40236 / JCM 4644 / NBRC 12875 / NCIMB 13023 / NRRL B-2682 / VKM Ac-800.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08763 Genomic DNA. Translation: CAA70012.1.
AJ862840 Genomic DNA. Translation: CAH94315.1.

3D structure databases

ProteinModelPortalP77952.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14011.
UniPathwayUPA00066.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000653. DegT/StrS_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF01041. DegT_DnrJ_EryC1. 1 hit.
[Graphical view]
PIRSFPIRSF000390. PLP_StrS. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_STRGR
AccessionPrimary (citable) accession number: P77952
Secondary accession number(s): Q53IE1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 1, 1997
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways