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Protein

RNA polymerase sigma factor SigA

Gene

sigA

Organism
Streptomyces griseus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi475 – 494H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Alternative name(s):
RNA polymerase principal sigma factor HrdB
Gene namesi
Name:sigAUniRule annotation
Synonyms:hrdB
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939921 – 514RNA polymerase sigma factor SigAAdd BLAST514

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP77951
SMRiP77951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 351Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni360 – 436Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni449 – 502Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi305 – 308Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoD/SigA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00963 Sigma70_RpoD_SigA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012760 RNA_pol_sigma_RpoD_C
IPR028630 Sigma70_RpoD
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02393 RpoD_Cterm, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P77951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASTSRTLP PEIAESESVM ALIERGKADG QIAGDDVRRA FEADQIPPTQ
60 70 80 90 100
WKNVLRSLNQ ILEEEGVTLM VSAAESPKRA RKSVAAKSPV KRTATKTVAA
110 120 130 140 150
KTTVTRTVAA TAAPAVESAD AADDAVAAAP AKKTAAKKAT AKKAAAKKTT
160 170 180 190 200
AKKTAAKKSG KQDDEILDGD EAAEEVKAGK GEEEEGEGEN KGFVLSDDDE
210 220 230 240 250
DDAPAQQVAV AGATADPVKD YLKQIGKVPL LNAEQEVELA KRIEAGLFAE
260 270 280 290 300
DKLANADKLA PKLKRELEII AEDGRRAKNH LLEANLRLVV SLAKRYTGRG
310 320 330 340 350
MLFLDLIQEG NLGLIRAVEK FDYTKGYKFS TYATWWIRQA ITRAMADQAR
360 370 380 390 400
TIRIPVHMVE VINKLARVQR QMLQDLGREP TPEELAKELD MTPEKVIEVQ
410 420 430 440 450
KYGREPISLH TPLGEDGDSE FGDLIEDSEA VVPADAVSFT LLQEQLHSVL
460 470 480 490 500
DTLSEREAGV VSMRFGLTDG QPKTLDEIGK VYGVTRERIR QIESKTMSKL
510
RHPSRSQVLR DYLD
Length:514
Mass (Da):56,133
Last modified:February 1, 1997 - v1
Checksum:i77873D66597C8A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08071 Genomic DNA Translation: AAB16905.1
RefSeqiWP_003965769.1, NZ_MDDK01000249.1

Genome annotation databases

GeneIDi6210716

Similar proteinsi

Entry informationi

Entry nameiSIGA_STRGR
AccessioniPrimary (citable) accession number: P77951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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