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P77947

- MASY_STRAE

UniProt

P77947 - MASY_STRAE

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Protein
Malate synthase
Gene
aceB
Organism
Streptomyces arenae
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase (EC:2.3.3.9)
Gene namesi
Name:aceB
OrganismiStreptomyces arenae
Taxonomic identifieri29301 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Malate synthase
PRO_0000166877Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP77947.

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77947-1 [UniParc]FASTAAdd to Basket

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MSAPAPSPLA IVDAEPLPRQ EEVLTDAALA FVAELLHRRF TRAVTNSSPR    50
RADAAREIAR TSTLDFLPET AAVRADDSWR VAGPAALNDR RVEITGPTDR 100
KMTINALNSG AKVWLADFEE PSAPTWENVV LGQVNLSDAY TRNIDFTDER 150
TGKTYALRPL KSWRPSSWPR GWHLNERHLV DPDGSFGARR VVVDFGLYFF 200
HNAQRLLDLG KGPYFYLPKT ESHLEARLWN DVFVFAQDYV GIPQGTVRAT 250
VLIETITAAY EMEEILYELR DHASGLNAGR WDYLFSIVKN FPATRPKFVL 300
PDRNVTMTKL TMTAFMRRYT NCSSYCHNAR ASAAIGGMAA FIPSRDAEVN 350
KVAFEKVRAD KDREANDGFD GSWVAHPDLV PIAMESFDRC WHRPNQKDRL 400
REDVHVEAAD LIAVDSLEAT TYAGSSSTAV QVGIRYIEAW LRGLGRVAIF 450
NLMEDAATAE ISRSQIWQWI NAGVEFEHGE KATPIWPRKS RRGRKWRPVR 500
EELGEEPFAA RDWQHAHDLV VQVSLDEDYA DFLTLPAYER LRG 543
Length:543
Mass (Da):61,408
Last modified:February 1, 1997 - v1
Checksum:i60829A40F62A0D85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63518 Genomic DNA. Translation: AAB53938.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U63518 Genomic DNA. Translation: AAB53938.1 .

3D structure databases

ProteinModelPortali P77947.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene cloning and sequencing, and enzyme purification of the malate synthase of Streptomyces arenae."
    Huettner S., Mecke D., Froehlich K.-U.
    Gene 188:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: Tu469.

Entry informationi

Entry nameiMASY_STRAE
AccessioniPrimary (citable) accession number: P77947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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