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P77947 (MASY_STRAE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate synthase

EC=2.3.3.9
Gene names
Name:aceB
OrganismStreptomyces arenae
Taxonomic identifier29301 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the malate synthase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmalate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Malate synthase
PRO_0000166877

Sequences

Sequence LengthMass (Da)Tools
P77947 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 60829A40F62A0D85

FASTA54361,408
        10         20         30         40         50         60 
MSAPAPSPLA IVDAEPLPRQ EEVLTDAALA FVAELLHRRF TRAVTNSSPR RADAAREIAR 

        70         80         90        100        110        120 
TSTLDFLPET AAVRADDSWR VAGPAALNDR RVEITGPTDR KMTINALNSG AKVWLADFEE 

       130        140        150        160        170        180 
PSAPTWENVV LGQVNLSDAY TRNIDFTDER TGKTYALRPL KSWRPSSWPR GWHLNERHLV 

       190        200        210        220        230        240 
DPDGSFGARR VVVDFGLYFF HNAQRLLDLG KGPYFYLPKT ESHLEARLWN DVFVFAQDYV 

       250        260        270        280        290        300 
GIPQGTVRAT VLIETITAAY EMEEILYELR DHASGLNAGR WDYLFSIVKN FPATRPKFVL 

       310        320        330        340        350        360 
PDRNVTMTKL TMTAFMRRYT NCSSYCHNAR ASAAIGGMAA FIPSRDAEVN KVAFEKVRAD 

       370        380        390        400        410        420 
KDREANDGFD GSWVAHPDLV PIAMESFDRC WHRPNQKDRL REDVHVEAAD LIAVDSLEAT 

       430        440        450        460        470        480 
TYAGSSSTAV QVGIRYIEAW LRGLGRVAIF NLMEDAATAE ISRSQIWQWI NAGVEFEHGE 

       490        500        510        520        530        540 
KATPIWPRKS RRGRKWRPVR EELGEEPFAA RDWQHAHDLV VQVSLDEDYA DFLTLPAYER 


LRG 

« Hide

References

[1]"Gene cloning and sequencing, and enzyme purification of the malate synthase of Streptomyces arenae."
Huettner S., Mecke D., Froehlich K.-U.
Gene 188:239-246(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: Tu469.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63518 Genomic DNA. Translation: AAB53938.1.

3D structure databases

ProteinModelPortalP77947.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00720.

Family and domain databases

InterProIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PANTHERPTHR21631:SF1. PTHR21631:SF1. 1 hit.
PfamPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF001363. Malate_synth. 1 hit.
SUPFAMSSF51645. SSF51645. 1 hit.
TIGRFAMsTIGR01344. malate_syn_A. 1 hit.
PROSITEPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMASY_STRAE
AccessionPrimary (citable) accession number: P77947
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: October 16, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways