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P77921

- COX4_PARDE

UniProt

P77921 - COX4_PARDE

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Protein

Cytochrome c oxidase subunit 4

Gene

ctaH

Organism
Paracoccus denitrificans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Not required for enzymatic activity or proton pumping of the cytochrome c oxidase complex.1 Publication

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV
Gene namesi
Name:ctaH
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 5049Cytochrome c oxidase subunit 4PRO_0000183904Add
BLAST

Structurei

Secondary structure

1
50
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi18 – 4730

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLEX-ray3.00D8-50[»]
ProteinModelPortaliP77921.
SMRiP77921. Positions 8-50.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77921.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1716CytoplasmicAdd
BLAST
Topological domaini50 – 501Periplasmic

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 4932HelicalAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.5.160. 1 hit.
InterProiIPR012422. Cyt_c_oxidase_su4_bac-aa3.
[Graphical view]
PfamiPF07835. COX4_pro_2. 1 hit.
[Graphical view]
SUPFAMiSSF81469. SSF81469. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77921-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASHHEITDH KHGEMDIRHQ QATFAGFIKG ATWVSILSIA VLVFLALANS
Length:50
Mass (Da):5,501
Last modified:January 23, 2007 - v3
Checksum:i1D6B6674CAF5EC88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08372 Genomic DNA. Translation: CAA69659.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08372 Genomic DNA. Translation: CAA69659.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QLE X-ray 3.00 D 8-50 [» ]
ProteinModelPortali P77921.
SMRi P77921. Positions 8-50.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P77921.

Family and domain databases

Gene3Di 1.20.5.160. 1 hit.
InterProi IPR012422. Cyt_c_oxidase_su4_bac-aa3.
[Graphical view ]
Pfami PF07835. COX4_pro_2. 1 hit.
[Graphical view ]
SUPFAMi SSF81469. SSF81469. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation, analysis, and deletion of the gene coding for subunit IV of cytochrome c oxidase in Paracoccus denitrificans."
    Witt H., Ludwig B.
    J. Biol. Chem. 272:5514-5517(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: Pd 1222.
  2. "Thermodynamic and structural stability of cytochrome c oxidase from Paracoccus denitrificans."
    Haltia T., Semo N., Arrondo J.L., Goni F.M., Freire E.
    Biochemistry 33:9731-9740(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-32.
  3. "Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans."
    Iwata S., Ostermeier C., Ludwig B., Michel H.
    Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiCOX4_PARDE
AccessioniPrimary (citable) accession number: P77921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3