P77921 (COX4_PARDE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV

Gene names

Name:

ctaH

Organism

Paracoccus denitrificans

Taxonomic identifier

266 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length	50 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Not required for enzymatic activity or proton pumping of the cytochrome c oxidase complex. Ref.1
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell inner membrane; Single-pass membrane protein.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.2

Chain

2 – 50

49

Cytochrome c oxidase subunit 4

PRO_0000183904

Regions

Topological domain

2 – 17

16

Cytoplasmic

Transmembrane

18 – 49

32

Helical

Topological domain

50

1

Periplasmic

Secondary structure

1

.

.

.

50

Helix Strand Turn

Details...

Helix

18 – 47

30

Sequences

	Sequence		Length	Mass (Da)
	P77921 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 1D6B6674CAF5EC88	FASTA	50	5,501
	10 20 30 40 50 MASHHEITDH KHGEMDIRHQ QATFAGFIKG ATWVSILSIA VLVFLALANS

References

[1]	"Isolation, analysis, and deletion of the gene coding for subunit IV of cytochrome c oxidase in Paracoccus denitrificans." Witt H., Ludwig B. J. Biol. Chem. 272:5514-5517(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: Pd 1222.
[2]	"Thermodynamic and structural stability of cytochrome c oxidase from Paracoccus denitrificans." Haltia T., Semo N., Arrondo J.L., Goni F.M., Freire E. Biochemistry 33:9731-9740(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-32.
[3]	"Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans." Iwata S., Ostermeier C., Ludwig B., Michel H. Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Y08372 Genomic DNA. Translation: CAA69659.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QLE	X-ray	3.00	D	8-50	[»]

ProteinModelPortal

P77921.

SMR

P77921. Positions 8-50.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.20.5.160. 1 hit.

InterPro

IPR012422. Cyt_c_oxidase_su4_bac-aa3.
[Graphical view]

Pfam

PF07835. COX4_pro_2. 1 hit.
[Graphical view]

SUPFAM

SSF81469. Cyt_c_oxidase_su4_bac-aa3. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P77921.

Entry information

Entry name

COX4_PARDE

Accession

Primary (citable) accession number: P77921

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program