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P77921 (COX4_PARDE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV
Gene names
Name:ctaH
OrganismParacoccus denitrificans
Taxonomic identifier266 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length50 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not required for enzymatic activity or proton pumping of the cytochrome c oxidase complex. Ref.1

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell inner membrane; Single-pass membrane protein.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 5049Cytochrome c oxidase subunit 4
PRO_0000183904

Regions

Topological domain2 – 1716Cytoplasmic
Transmembrane18 – 4932Helical
Topological domain501Periplasmic

Secondary structure

... 50
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P77921 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 1D6B6674CAF5EC88

FASTA505,501
        10         20         30         40         50 
MASHHEITDH KHGEMDIRHQ QATFAGFIKG ATWVSILSIA VLVFLALANS 

« Hide

References

[1]"Isolation, analysis, and deletion of the gene coding for subunit IV of cytochrome c oxidase in Paracoccus denitrificans."
Witt H., Ludwig B.
J. Biol. Chem. 272:5514-5517(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: Pd 1222.
[2]"Thermodynamic and structural stability of cytochrome c oxidase from Paracoccus denitrificans."
Haltia T., Semo N., Arrondo J.L., Goni F.M., Freire E.
Biochemistry 33:9731-9740(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-32.
[3]"Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans."
Iwata S., Ostermeier C., Ludwig B., Michel H.
Nature 376:660-669(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08372 Genomic DNA. Translation: CAA69659.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLEX-ray3.00D8-50[»]
ProteinModelPortalP77921.
SMRP77921. Positions 8-50.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.5.160. 1 hit.
InterProIPR012422. Cyt_c_oxidase_su4_bac-aa3.
[Graphical view]
PfamPF07835. COX4_pro_2. 1 hit.
[Graphical view]
SUPFAMSSF81469. SSF81469. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP77921.

Entry information

Entry nameCOX4_PARDE
AccessionPrimary (citable) accession number: P77921
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references