P77919 (PYRI_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase regulatory chain

Gene names

Name:	pyrI
Ordered Locus Names:	PYRAB13260
ORF Names:	PAB1499

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in allosteric regulation of aspartate carbamoyltransferase By similarity. HAMAP-Rule MF_00002
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00002
Subunit structure	Contains catalytic and regulatory chains By similarity. HAMAP-Rule MF_00002
Sequence similarities	Belongs to the PyrI family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	aspartate carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	Aspartate carbamoyltransferase regulatory chain HAMAP-Rule MF_00002		PRO_0000142337
Sites
	Metal binding	108	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity
	Metal binding	136	1	Zinc By similarity
	Metal binding	139	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	P77919 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 05DEE2DD0839A384	FASTA	152	16,958
	10 20 30 40 50 60 MAELKVSAIK EGTVIDHIPA GKGLKVIEIL KLGKLTNGGA VLLAMNVPSK KLGRKDIVKV 70 80 90 100 110 120 EGRFLSEEEV NKIALVAPNA TVNIIRDYKV VEKFKVEVPD VIEGILRCGN PNCITNHEYV 130 140 150 TTKFYVISRE PLKVRCHYCE RTMEEEEILA NL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Aspartate transcarbamylase from the deep-sea hyperthermophilic archaeon Pyrococcus abyssi: genetic organization, structure, and expression in Escherichia coli." Purcarea C., Herve G., Ladjimi M.M., Cunin R. J. Bacteriol. 179:4143-4157(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[3]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U61765 Genomic DNA. Translation: AAB62985.1. AJ248287 Genomic DNA. Translation: CAB50231.1. HE613800 Genomic DNA. Translation: CCE70768.1.
PIR	B75042.
RefSeq	NP_127001.1. NC_000868.1.
3D structure databases
ProteinModelPortal	P77919.
SMR	P77919. Positions 5-146.
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB1499.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB50231; CAB50231; PAB1499.
GeneID	1496714.
KEGG	pab:PAB1499.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1781.
HOGENOM	HOG000113530.
KO	K00610.
OMA	TVIDHIT.
ProtClustDB	PRK00893.
Family and domain databases
Gene3D	2.30.30.20. 1 hit. 3.30.70.140. 1 hit.
HAMAP	MF_00002. Asp_carb_tr_reg.
InterPro	IPR020545. Asp_carbamoyltransf_reg_N. IPR002801. Asp_carbamoylTrfase_reg. IPR020542. Asp_carbamoyltrfase_reg_C. [Graphical view]
Pfam	PF01948. PyrI. 1 hit. PF02748. PyrI_C. 1 hit. [Graphical view]
ProDom	PD006194. Asp_carbamoylTrfase_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54893. Asp_carbamoylTrfase_reg. 1 hit. SSF57825. Asp_transf_reg_C. 1 hit.
TIGRFAMs	TIGR00240. ATCase_reg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRI_PYRAB

Accession

Primary (citable) accession number: P77919
Secondary accession number(s): G8ZHD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program