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P77919

- PYRI_PYRAB

UniProt

P77919 - PYRI_PYRAB

Protein

Aspartate carbamoyltransferase regulatory chain

Gene

pyrI

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Involved in allosteric regulation of aspartate carbamoyltransferase.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi108 – 1081ZincBy similarity
    Metal bindingi113 – 1131ZincBy similarity
    Metal bindingi136 – 1361ZincBy similarity
    Metal bindingi139 – 1391ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. pyrimidine nucleotide biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate carbamoyltransferase regulatory chain
    Gene namesi
    Name:pyrI
    Ordered Locus Names:PYRAB13260
    ORF Names:PAB1499
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. aspartate carbamoyltransferase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Aspartate carbamoyltransferase regulatory chainPRO_0000142337Add
    BLAST

    Interactioni

    Subunit structurei

    Contains catalytic and regulatory chains.By similarity

    Protein-protein interaction databases

    STRINGi272844.PAB1499.

    Structurei

    3D structure databases

    ProteinModelPortaliP77919.
    SMRiP77919. Positions 5-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PyrI family.Curated

    Phylogenomic databases

    eggNOGiCOG1781.
    HOGENOMiHOG000113530.
    KOiK00610.
    OMAiCITSIEQ.

    Family and domain databases

    Gene3Di2.30.30.20. 1 hit.
    3.30.70.140. 1 hit.
    HAMAPiMF_00002. Asp_carb_tr_reg.
    InterProiIPR020545. Asp_carbamoyltransf_reg_N.
    IPR002801. Asp_carbamoylTrfase_reg.
    IPR020542. Asp_carbamoyltrfase_reg_C.
    [Graphical view]
    PfamiPF01948. PyrI. 1 hit.
    PF02748. PyrI_C. 1 hit.
    [Graphical view]
    ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54893. SSF54893. 1 hit.
    SSF57825. SSF57825. 1 hit.
    TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P77919-1 [UniParc]FASTAAdd to Basket

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    MAELKVSAIK EGTVIDHIPA GKGLKVIEIL KLGKLTNGGA VLLAMNVPSK    50
    KLGRKDIVKV EGRFLSEEEV NKIALVAPNA TVNIIRDYKV VEKFKVEVPD 100
    VIEGILRCGN PNCITNHEYV TTKFYVISRE PLKVRCHYCE RTMEEEEILA 150
    NL 152
    Length:152
    Mass (Da):16,958
    Last modified:February 1, 1997 - v1
    Checksum:i05DEE2DD0839A384
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61765 Genomic DNA. Translation: AAB62985.1.
    AJ248287 Genomic DNA. Translation: CAB50231.1.
    HE613800 Genomic DNA. Translation: CCE70768.1.
    PIRiB75042.
    RefSeqiNP_127001.1. NC_000868.1.
    WP_010868441.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50231; CAB50231; PAB1499.
    GeneIDi1496714.
    KEGGipab:PAB1499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61765 Genomic DNA. Translation: AAB62985.1 .
    AJ248287 Genomic DNA. Translation: CAB50231.1 .
    HE613800 Genomic DNA. Translation: CCE70768.1 .
    PIRi B75042.
    RefSeqi NP_127001.1. NC_000868.1.
    WP_010868441.1. NC_000868.1.

    3D structure databases

    ProteinModelPortali P77919.
    SMRi P77919. Positions 5-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272844.PAB1499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50231 ; CAB50231 ; PAB1499 .
    GeneIDi 1496714.
    KEGGi pab:PAB1499.

    Phylogenomic databases

    eggNOGi COG1781.
    HOGENOMi HOG000113530.
    KOi K00610.
    OMAi CITSIEQ.

    Family and domain databases

    Gene3Di 2.30.30.20. 1 hit.
    3.30.70.140. 1 hit.
    HAMAPi MF_00002. Asp_carb_tr_reg.
    InterProi IPR020545. Asp_carbamoyltransf_reg_N.
    IPR002801. Asp_carbamoylTrfase_reg.
    IPR020542. Asp_carbamoyltrfase_reg_C.
    [Graphical view ]
    Pfami PF01948. PyrI. 1 hit.
    PF02748. PyrI_C. 1 hit.
    [Graphical view ]
    ProDomi PD006194. Asp_carbamoylTrfase_reg. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54893. SSF54893. 1 hit.
    SSF57825. SSF57825. 1 hit.
    TIGRFAMsi TIGR00240. ATCase_reg. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Aspartate transcarbamylase from the deep-sea hyperthermophilic archaeon Pyrococcus abyssi: genetic organization, structure, and expression in Escherichia coli."
      Purcarea C., Herve G., Ladjimi M.M., Cunin R.
      J. Bacteriol. 179:4143-4157(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    3. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiPYRI_PYRAB
    AccessioniPrimary (citable) accession number: P77919
    Secondary accession number(s): G8ZHD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3