Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BRENDAi2.1.3.2. 5242.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase (EC:2.1.3.2)
Alternative name(s):
Aspartate transcarbamylase
Short name:
ATCase
Gene namesi
Name:pyrB
Ordered Locus Names:PYRAB13270
ORF Names:PAB1498
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132531 – 308Aspartate carbamoyltransferaseAdd BLAST308

Interactioni

Subunit structurei

Heterooligomer of catalytic and regulatory chains.1 Publication

Protein-protein interaction databases

STRINGi272844.PAB1498.

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 13Combined sources3
Helixi16 – 36Combined sources21
Turni41 – 44Combined sources4
Beta strandi46 – 53Combined sources8
Helixi57 – 68Combined sources12
Beta strandi72 – 77Combined sources6
Helixi79 – 81Combined sources3
Helixi83 – 86Combined sources4
Helixi90 – 97Combined sources8
Turni98 – 100Combined sources3
Beta strandi102 – 110Combined sources9
Helixi113 – 119Combined sources7
Beta strandi125 – 130Combined sources6
Helixi136 – 149Combined sources14
Beta strandi153 – 162Combined sources10
Turni164 – 166Combined sources3
Helixi168 – 176Combined sources9
Helixi177 – 179Combined sources3
Beta strandi182 – 187Combined sources6
Helixi190 – 192Combined sources3
Helixi196 – 204Combined sources9
Beta strandi209 – 213Combined sources5
Helixi216 – 219Combined sources4
Beta strandi223 – 227Combined sources5
Helixi232 – 234Combined sources3
Beta strandi235 – 237Combined sources3
Helixi238 – 242Combined sources5
Turni243 – 246Combined sources4
Helixi254 – 257Combined sources4
Beta strandi263 – 265Combined sources3
Beta strandi271 – 274Combined sources4
Helixi276 – 280Combined sources5
Helixi286 – 291Combined sources6
Helixi293 – 304Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ML4X-ray1.80A1-308[»]
ProteinModelPortaliP77918.
SMRiP77918.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77918.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00911. Archaea.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiKQSFYGV.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWKGRDVIS IRDFSKEDIE TVLATAERLE RELKEKGQLE YAKGKILATL
60 70 80 90 100
FFEPSTRTRL SFESAMHRLG GAVIGFAEAS TSSVKKGESL RDTIKTVEQY
110 120 130 140 150
CDVIVIRHPK EGAARLAAEV AEVPVINAGD GSNQHPTQTL LDLYTIKKEF
160 170 180 190 200
GRIDGLKIGL LGDLKYGRTV HSLAEALTFY DVELYLISPE LLRMPRHIVE
210 220 230 240 250
ELREKGMKVV ETTTLEDVIG KLDVLYVTRI QKERFPDEQE YLKVKGSYQV
260 270 280 290 300
NLKVLEKAKD ELRIMHPLPR VDEIHPEVDN TKHAIYFRQV FNGVPVRMAL

LALVLGVI
Length:308
Mass (Da):34,901
Last modified:February 1, 1997 - v1
Checksum:iD36961E7749C012E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61765 Genomic DNA. Translation: AAB62984.1.
AJ248287 Genomic DNA. Translation: CAB50232.1.
HE613800 Genomic DNA. Translation: CCE70769.1.
PIRiC75042.
RefSeqiWP_010868442.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50232; CAB50232; PAB1498.
GeneIDi1496715.
KEGGipab:PAB1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61765 Genomic DNA. Translation: AAB62984.1.
AJ248287 Genomic DNA. Translation: CAB50232.1.
HE613800 Genomic DNA. Translation: CCE70769.1.
PIRiC75042.
RefSeqiWP_010868442.1. NC_000868.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ML4X-ray1.80A1-308[»]
ProteinModelPortaliP77918.
SMRiP77918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB1498.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50232; CAB50232; PAB1498.
GeneIDi1496715.
KEGGipab:PAB1498.

Phylogenomic databases

eggNOGiarCOG00911. Archaea.
COG0540. LUCA.
HOGENOMiHOG000022685.
KOiK00609.
OMAiKQSFYGV.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00116.
BRENDAi2.1.3.2. 5242.

Miscellaneous databases

EvolutionaryTraceiP77918.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRB_PYRAB
AccessioniPrimary (citable) accession number: P77918
Secondary accession number(s): G8ZHD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.