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P77918 (PYRB_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:PYRAB13270
ORF Names:PAB1498
OrganismPyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]
Taxonomic identifier272844 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001

Subunit structure

Heterooligomer of catalytic and regulatory chains.

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Aspartate carbamoyltransferase HAMAP MF_00001
PRO_0000113253

Secondary structure

1 ................................................................ 308
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P77918 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: D36961E7749C012E

FASTA30834,901
        10         20         30         40         50         60 
MDWKGRDVIS IRDFSKEDIE TVLATAERLE RELKEKGQLE YAKGKILATL FFEPSTRTRL 

        70         80         90        100        110        120 
SFESAMHRLG GAVIGFAEAS TSSVKKGESL RDTIKTVEQY CDVIVIRHPK EGAARLAAEV 

       130        140        150        160        170        180 
AEVPVINAGD GSNQHPTQTL LDLYTIKKEF GRIDGLKIGL LGDLKYGRTV HSLAEALTFY 

       190        200        210        220        230        240 
DVELYLISPE LLRMPRHIVE ELREKGMKVV ETTTLEDVIG KLDVLYVTRI QKERFPDEQE 

       250        260        270        280        290        300 
YLKVKGSYQV NLKVLEKAKD ELRIMHPLPR VDEIHPEVDN TKHAIYFRQV FNGVPVRMAL 


LALVLGVI

« Hide

References

« Hide 'large scale' references
[1]"Aspartate transcarbamylase from the deep-sea hyperthermophilic archaeon Pyrococcus abyssi: genetic organization, structure, and expression in Escherichia coli."
Purcarea C., Herve G., Ladjimi M.M., Cunin R.
J. Bacteriol. 179:4143-4157(1997) [PubMed: 9209027] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GE5 / Orsay.
[2]"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi."
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.
Mol. Microbiol. 47:1495-1512(2003) [PubMed: 12622808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GE5 / Orsay.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U61765 Genomic DNA. Translation: AAB62984.1.
AJ248287 Genomic DNA. Translation: CAB50232.1.
PIRC75042.
RefSeqNP_127002.1. NC_000868.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ML4X-ray1.80A1-308[»]
ProteinModelPortalP77918.
SMRP77918. Positions 2-308.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000003467; EBPYRP00000003398; EBPYRG00000003467.
GeneID1496715.
GenomeReviewsGene locus PYRAB13270 in contig AL096836_GR.
KEGGpab:PAB1498.
NMPDRfig|272844.1.peg.1408.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022978.
HOGENOMHBG579429.
OMAFKQSFYG.
PhylomeDBP77918.
ProtClustDBPRK00856.

Enzyme and pathway databases

BioCycPABY272844:PAB1498-MONOMER.

Family and domain databases

HAMAPMF_00001. Asp_carb_tr.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002082. Asp_carbamoyltransf_euk.
[Graphical view]
KOK00609.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00670. Asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_PYRAB
AccessionPrimary (citable) accession number: P77918
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: December 14, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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