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Protein
Submitted name:

Formate dehydrogenase alpha subunit

Gene

fdha

Organism
Moorella thermoacetica (Clostridium thermoaceticum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Mo-bis(molybdopterin guanine dinucleotide)SAAS annotation
  • [4Fe-4S] clusterSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationImported

Keywords - Ligandi

4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding, MolybdenumSAAS annotation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-4213.

Names & Taxonomyi

Protein namesi
Submitted name:
Formate dehydrogenase alpha subunitImported (EC:1.2.1.43Imported)
Gene namesi
Name:fdhaImported
OrganismiMoorella thermoacetica (Clostridium thermoaceticum)Imported
Taxonomic identifieri1525 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_2312.

Structurei

3D structure databases

ProteinModelPortaliP77908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 78782Fe-2S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini137 – 167314Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini183 – 212304Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini221 – 277574Fe-4S Mo/W bis-MGD-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 4Fe-4S Mo/W bis-MGD-type domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108HIZ. Bacteria.
COG3383. LUCA.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR012675. Beta-grasp_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLTIDGQR VTAPEGMTIL EVARENGIHI PTLCHHPKLR PLGYCRLCLV
60 70 80 90 100
DIEGAAKPMT ACNTPVAEGM VIRTSTPVIE EMRKGIIEML LSLHPEDCLT
110 120 130 140 150
CEKAGNCQLQ DCAYTYGVKH GELPVKREEL PVLKENPFIV RDYNKCIVCG
160 170 180 190 200
RCVRACQEVQ VQRVVDLVGK GSAARVGATK AGAEVSLEEG GCVFCGNCVQ
210 220 230 240 250
VCPVGALTEK AGLGQGREWE FKKVRSICSY CGVGCNLTLY VKDGKVVKVR
260 270 280 290 300
GYENPEVNNG WLCVKGRFGF DYIHNPDRIT RPLIREGDRE KGYFREASWE
310 320 330 340 350
EALALVSQKL TQIKGSYGSE ALGFLCSAKC TNEENYLLQK LARGVLGTNN
360 370 380 390 400
VDHCARLXHS STVAGLATTF GSGAMTNSIA DIASADCIFV IGSNTTENHP
410 420 430 440 450
VIALKVKEAV RRGARLIVAD PRRIELVNFS YLWLRQKPGT DLALLNGLLH
460 470 480 490 500
VIIKEELYDK EFIAQRTEGF EALKLAVEEY TPAKVSEVTG VPAGDIIEAA
510 520 530 540 550
RTYARGPSST ILYAMGITQH ITGTANVMAL ANLAMACGQV GKEGNGVNPL
560 570 580 590 600
RGQSNVQGAC DMGGLPNVLP GYQPVTDPGV RHKFSETWGV PDLPGEPGLT
610 620 630 640 650
LMEMMAAAQE GKLKGMYILG ENPVLTDPDV SHVKEALKNL EFLVVQDIFL
660 670 680 690 700
TETARMADVV LPGASFAEKE GTFTSTERRV QLLHKAIEPP GEARPDWLIL
710 720 730 740 750
NDLLLLMGYP RKYSSPGEIM QEIAGLTPSY AGITYERLED KGLQWPVLSL
760 770 780 790 800
EHPGTPVLHR EKFSRGYGQF QVVHYRPPAE EPDEEYPFLF TTGRNLYHYH
810 820 830 840 850
TVISRKSRGL EEMCPAPVVE INDNDAARLG IREGEMIEIV SRRGKVRVKA
860 870 880 890
LVTDRIPRGQ VFMNFHFHEA AANLLTIAAL DPVAKIPIIK PVL
Length:893
Mass (Da):97,972
Last modified:March 1, 2003 - v3
Checksum:i3C9769FCB3FA99AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73807 Genomic DNA. Translation: AAB18330.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73807 Genomic DNA. Translation: AAB18330.2.

3D structure databases

ProteinModelPortaliP77908.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264732.Moth_2312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108HIZ. Bacteria.
COG3383. LUCA.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-4213.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR012675. Beta-grasp_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP77908_MOOTH
AccessioniPrimary (citable) accession number: P77908
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.