Probable cation-transporting ATPase V - Mycobacterium tuberculosis

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P77894 (CTPV_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable cation-transporting ATPase V
EC=3.6.3.-

Gene names

Name:	ctpV
Ordered Locus Names:	Rv0969, MT0997
ORF Names:	MTCY10D7.05c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	770 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + H₂O = ADP + phosphate.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]
Sequence caution	The sequence AAK45246.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro response to copper ion Inferred from expression pattern. Source: MTBBASE response to host immune response Inferred from expression pattern. Source: MTBBASE
Cellular component	integral to plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 770

770

Probable cation-transporting ATPase V

PRO_0000046348

Regions

Transmembrane

38 – 58

Helical; Potential

Transmembrane

141 – 161

Helical; Potential

Transmembrane

164 – 184

Helical; Potential

Transmembrane

193 – 213

Helical; Potential

Transmembrane

217 – 237

Helical; Potential

Transmembrane

378 – 398

Helical; Potential

Transmembrane

402 – 422

Helical; Potential

Transmembrane

489 – 509

Helical; Potential

Transmembrane

571 – 591

Helical; Potential

Transmembrane

665 – 685

Helical; Potential

Transmembrane

728 – 748

Helical; Potential

Sites

Active site

460

4-aspartylphosphate intermediate By similarity

Metal binding

660

Magnesium By similarity

Metal binding

664

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P77894 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 08CE6D54EF4F9ECA
Show »

FASTA

770

80,103

        10         20         30         40         50         60 
MRVCVTGFNV DAVRAVAIEE TVSQVTGVHA VHAYPRTASV VIWYSPELGD TAAVLSAITK 

        70         80         90        100        110        120 
AQHVPAELVP ARAPHSAGVR GVGVVRKITG GIRRMLSRPP GVDKPLKASR CGGRPRGPVR 

       130        140        150        160        170        180 
GSASWPGEQN RRERRTWLPR VWLALPLGLL ALGSSMFFGA YPWAGWLAFA ATLPVQFVAG 

       190        200        210        220        230        240 
WPILRGAVQQ ARALTSNMDT LIALGTLTAF VYSTYQLFAG GPLFFDTSAL IIAFVVLGRH 

       250        260        270        280        290        300 
LEARATGKAS EAISKLLELG AKEATLLVDG QELLVPVDQV QVGDLVRVRP GEKIPVDGEV 

       310        320        330        340        350        360 
TDGRAAVDES MLTGESVPVE KTAGDRVAGA TVNLDGLLTV RATAVGADTA LAQIVRLVEQ 

       370        380        390        400        410        420 
AQGDKAPVQR LADRVSAVFV PAVIGVAVAT FAGWTLIAAN PVAGMTAAVA VLIIACPCAL 

       430        440        450        460        470        480 
GLATPTAIMV GTGRGAELGI LVKGGEVLEA SKKIDTVVFD KTGTLTRARM RVTDVIAGQR 

       490        500        510        520        530        540 
RQPDQVLRLA AAVESGSEHP IGAAIVAAAH ERGLAIPAAN AFTAVAGHGV RAQVNGGPVV 

       550        560        570        580        590        600 
VGRRKLVDEQ HLVLPDHLAA AAVEQEERGR TAVFVGQDGQ VVGVLAVADT VKDDAADVVG 

       610        620        630        640        650        660 
RLHAMGLQVA MITGDNARTA AAIAKQVGIE KVLAEVLPQD KVAEVRRLQD QGRVVAMVGD 

       670        680        690        700        710        720 
GVNDAPALVQ ADLGIAIGTG TDVAIEASDI TLMSGRLDGV VRAIELSRQT LRTIYQNLGW 

       730        740        750        760        770 
AFGYNTAAIP LAALGALNPV VAGAAMGFSS VSVVTNSLRL RRFGRDGRTA

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References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.

Barrell B.G.
Nature 393:537-544(1998) [PubMed: 9634230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R.

Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842575 Genomic DNA. Translation: CAB01983.1. AE000516 Genomic DNA. Translation: AAK45246.1. Different initiation.
PIR	G70718.
RefSeq	NP_335432.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P77894.
SMR	P77894. Positions 251-363.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000965; EBMYCP00000000965; EBMYCG00000000965. EBMYCT00000069649; EBMYCP00000067708; EBMYCG00000069644.
GeneID	926452.
GenomeReviews	Gene locus MT0997 in contig AE000516_GR. Gene locus Rv0969 in contig AL123456_GR.
KEGG	mtc:MT0997. mtu:Rv0969.
PATRIC	18123936. VBIMycTub22151_1091.
TIGR	MT0997.
Organism-specific databases
TubercuList	Rv0969.
Phylogenomic databases
GeneTree	EBGT00050000016190.
HOGENOM	HBG507745.
OMA	WLYSFIV.
PhylomeDB	P77894.
ProtClustDB	CLSK790863.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR000695. ATPase_P-typ_H-transp. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K12956.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTPV_MYCTU

Accession

Primary (citable) accession number: P77894

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents