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P77872 (CATA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catalase

EC=1.11.1.6
Gene names
Name:katA
Ordered Locus Names:HP_0875
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the catalase family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HP_0874O255423EBI-7585674,EBI-7585664

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Catalase
PRO_0000084987

Sites

Active site561 By similarity
Active site1291 By similarity
Metal binding3391Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict821S → F in AAC16068. Ref.1
Sequence conflict2341V → I in CAA94567. Ref.2
Sequence conflict2371Y → H in CAA94567. Ref.2
Sequence conflict2481N → D in CAA94567. Ref.2
Sequence conflict2551F → Y in CAA94567. Ref.2
Sequence conflict2861L → T in CAA94567. Ref.2
Sequence conflict3131A → V in AAC16068. Ref.1
Sequence conflict3161S → T in AAC16068. Ref.1
Sequence conflict3161S → T in CAA94567. Ref.2

Secondary structure

............................................................................ 505
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P77872 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 9F029B55B73C26EA

FASTA50558,629
        10         20         30         40         50         60 
MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI PERVVHAKGS 

        70         80         90        100        110        120 
GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE RGSADAVRDP RGFAMKYYTE 

       130        140        150        160        170        180 
EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK RDPQTNLPNH DMVWDFWSNV PESLYQVTWV 

       190        200        210        220        230        240 
MSDRGIPKSF RHMDGFGSHT FSLINAKGER FWVKFHFHTM QGVKHLTNEE AAEVRKYDPD 

       250        260        270        280        290        300 
SNQRDLFNAI ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN 

       310        320        330        340        350        360 
KNPENYFAEV EQAAFSPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN YPQIPVNKPR 

       370        380        390        400        410        420 
CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP KFNLAHIEKE FEVWNWDYRA 

       430        440        450        460        470        480 
DDSDYYTQPG DYYRSLPADE KERLHDTIGE SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK 

       490        500 
KALEKHQKMM KDMHGKDMHH TKKKK 

« Hide

References

« Hide 'large scale' references
[1]"An investigation of the molecular basis of the spontaneous occurrence of a catalase-negative phenotype in Helicobacter pylori."
Manos J., Kolesnikow T., Hazell S.L.
Helicobacter 3:28-38(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: RU1.
[2]"Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain."
Odenbreit S., Wieland B., Haas R.
J. Bacteriol. 178:6960-6967(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: P1.
[3]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67458 Genomic DNA. Translation: AAC16068.1.
Z70679 Genomic DNA. Translation: CAA94567.1.
AE000511 Genomic DNA. Translation: AAD07923.1.
PIRC64629.
RefSeqNP_207669.1. NC_000915.1.
YP_006934789.1. NC_018939.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QWLX-ray1.60A/B1-505[»]
1QWMX-ray1.60A/B1-505[»]
2A9EX-ray1.76A/B1-505[»]
2IQFX-ray1.86A/B1-505[»]
ProteinModelPortalP77872.
SMRP77872. Positions 1-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3559N.
IntActP77872. 2 interactions.
MINTMINT-165967.
STRING85962.HP0875.

Proteomic databases

PRIDEP77872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07923; AAD07923; HP_0875.
GeneID899404.
KEGGheo:C694_04480.
hpy:HP0875.
PATRIC20593039. VBIHelPyl33062_0907.

Phylogenomic databases

eggNOGCOG0753.
KOK03781.
OMAEFECTED.
OrthoDBEOG6P5Z9F.

Enzyme and pathway databases

SABIO-RKP77872.

Family and domain databases

Gene3D2.40.180.10. 1 hit.
InterProIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERPTHR11465. PTHR11465. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSPR00067. CATALASE.
SMARTSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMSSF56634. SSF56634. 1 hit.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP77872.

Entry information

Entry nameCATA_HELPY
AccessionPrimary (citable) accession number: P77872
Secondary accession number(s): P94823
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names