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P77872

- CATA_HELPY

UniProt

P77872 - CATA_HELPY

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Protein

Catalase

Gene
katA, HP_0875
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.

Cofactori

Heme group.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561 By similarity
Active sitei129 – 1291 By similarity
Metal bindingi339 – 3391Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP77872.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:HP_0875
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505CatalasePRO_0000084987Add
BLAST

Proteomic databases

PRIDEiP77872.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_0874O255423EBI-7585674,EBI-7585664

Protein-protein interaction databases

DIPiDIP-3559N.
IntActiP77872. 2 interactions.
MINTiMINT-165967.
STRINGi85962.HP0875.

Structurei

Secondary structure

1
505
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 263
Helixi36 – 4510
Beta strandi58 – 6811
Turni73 – 753
Helixi79 – 813
Beta strandi87 – 959
Beta strandi105 – 1095
Beta strandi112 – 1198
Beta strandi122 – 13211
Helixi139 – 1413
Helixi142 – 1498
Turni153 – 1553
Helixi160 – 16910
Helixi171 – 1733
Helixi174 – 1818
Helixi183 – 1853
Beta strandi186 – 1894
Helixi190 – 1923
Beta strandi201 – 2044
Beta strandi210 – 21910
Helixi228 – 2358
Helixi241 – 25111
Beta strandi257 – 26610
Helixi267 – 2693
Turni270 – 2723
Turni286 – 2883
Beta strandi292 – 30110
Helixi306 – 3094
Turni310 – 3123
Helixi330 – 34718
Helixi351 – 3533
Helixi355 – 3573
Turni376 – 3794
Beta strandi387 – 3893
Helixi395 – 3973
Helixi404 – 4063
Helixi418 – 4214
Helixi427 – 4359
Helixi438 – 45215
Helixi458 – 47114
Helixi473 – 48917

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QWLX-ray1.60A/B1-505[»]
1QWMX-ray1.60A/B1-505[»]
2A9EX-ray1.76A/B1-505[»]
2IQFX-ray1.86A/B1-505[»]
ProteinModelPortaliP77872.
SMRiP77872. Positions 1-491.

Miscellaneous databases

EvolutionaryTraceiP77872.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.

Phylogenomic databases

eggNOGiCOG0753.
KOiK03781.
OMAiEFECTED.
OrthoDBiEOG6P5Z9F.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77872-1 [UniParc]FASTAAdd to Basket

« Hide

MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI    50
PERVVHAKGS GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE 100
RGSADAVRDP RGFAMKYYTE EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK 150
RDPQTNLPNH DMVWDFWSNV PESLYQVTWV MSDRGIPKSF RHMDGFGSHT 200
FSLINAKGER FWVKFHFHTM QGVKHLTNEE AAEVRKYDPD SNQRDLFNAI 250
ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN 300
KNPENYFAEV EQAAFSPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN 350
YPQIPVNKPR CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP 400
KFNLAHIEKE FEVWNWDYRA DDSDYYTQPG DYYRSLPADE KERLHDTIGE 450
SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK KALEKHQKMM KDMHGKDMHH 500
TKKKK 505
Length:505
Mass (Da):58,629
Last modified:November 1, 1997 - v2
Checksum:i9F029B55B73C26EA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821S → F in AAC16068. 1 Publication
Sequence conflicti234 – 2341V → I in CAA94567. 1 Publication
Sequence conflicti237 – 2371Y → H in CAA94567. 1 Publication
Sequence conflicti248 – 2481N → D in CAA94567. 1 Publication
Sequence conflicti255 – 2551F → Y in CAA94567. 1 Publication
Sequence conflicti286 – 2861L → T in CAA94567. 1 Publication
Sequence conflicti313 – 3131A → V in AAC16068. 1 Publication
Sequence conflicti316 – 3161S → T in AAC16068. 1 Publication
Sequence conflicti316 – 3161S → T in CAA94567. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67458 Genomic DNA. Translation: AAC16068.1.
Z70679 Genomic DNA. Translation: CAA94567.1.
AE000511 Genomic DNA. Translation: AAD07923.1.
PIRiC64629.
RefSeqiNP_207669.1. NC_000915.1.
YP_006934789.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07923; AAD07923; HP_0875.
GeneIDi13870059.
899404.
KEGGiheo:C694_04480.
hpy:HP0875.
PATRICi20593039. VBIHelPyl33062_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67458 Genomic DNA. Translation: AAC16068.1 .
Z70679 Genomic DNA. Translation: CAA94567.1 .
AE000511 Genomic DNA. Translation: AAD07923.1 .
PIRi C64629.
RefSeqi NP_207669.1. NC_000915.1.
YP_006934789.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QWL X-ray 1.60 A/B 1-505 [» ]
1QWM X-ray 1.60 A/B 1-505 [» ]
2A9E X-ray 1.76 A/B 1-505 [» ]
2IQF X-ray 1.86 A/B 1-505 [» ]
ProteinModelPortali P77872.
SMRi P77872. Positions 1-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3559N.
IntActi P77872. 2 interactions.
MINTi MINT-165967.
STRINGi 85962.HP0875.

Proteomic databases

PRIDEi P77872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07923 ; AAD07923 ; HP_0875 .
GeneIDi 13870059.
899404.
KEGGi heo:C694_04480.
hpy:HP0875.
PATRICi 20593039. VBIHelPyl33062_0907.

Phylogenomic databases

eggNOGi COG0753.
KOi K03781.
OMAi EFECTED.
OrthoDBi EOG6P5Z9F.

Enzyme and pathway databases

SABIO-RK P77872.

Miscellaneous databases

EvolutionaryTracei P77872.

Family and domain databases

Gene3Di 2.40.180.10. 1 hit.
InterProi IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view ]
PANTHERi PTHR11465. PTHR11465. 1 hit.
Pfami PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view ]
PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSi PR00067. CATALASE.
SMARTi SM01060. Catalase. 1 hit.
[Graphical view ]
SUPFAMi SSF56634. SSF56634. 1 hit.
PROSITEi PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An investigation of the molecular basis of the spontaneous occurrence of a catalase-negative phenotype in Helicobacter pylori."
    Manos J., Kolesnikow T., Hazell S.L.
    Helicobacter 3:28-38(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RU1.
  2. "Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain."
    Odenbreit S., Wieland B., Haas R.
    J. Bacteriol. 178:6960-6967(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: P1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCATA_HELPY
AccessioniPrimary (citable) accession number: P77872
Secondary accession number(s): P94823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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