Reviewed, UniProtKB/Swiss-Prot P77872 (CATA_HELPY)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:	katA
Ordered Locus Names:	HP_0875

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H(2)O(2) = O(2) + 2 H(2)O.
Cofactor	Heme group.
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Cytoplasm
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 505

505

Catalase

PRO_0000084987

Sites

Active site

56

1

By similarity

Active site

129

1

By similarity

Metal binding

339

1

Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict

82

1

S → F in AAC16068. Ref.1

Sequence conflict

234

1

V → I in CAA94567. Ref.2

Sequence conflict

237

1

Y → H in CAA94567. Ref.2

Sequence conflict

248

1

N → D in CAA94567. Ref.2

Sequence conflict

255

1

F → Y in CAA94567. Ref.2

Sequence conflict

286

1

L → T in CAA94567. Ref.2

Sequence conflict

313

1

A → V in AAC16068. Ref.1

Sequence conflict

316

1

S → T in AAC16068 and CAA94567. Ref.2

Secondary structure

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505

Helix Strand Turn

Details...

Beta strand

24 – 26

3

Helix

36 – 45

10

Beta strand

58 – 68

11

Turn

73 – 75

3

Helix

79 – 81

3

Beta strand

87 – 95

9

Beta strand

105 – 109

5

Beta strand

112 – 119

8

Beta strand

122 – 132

11

Helix

139 – 141

3

Helix

142 – 149

8

Turn

153 – 155

3

Helix

160 – 169

10

Helix

171 – 173

3

Helix

174 – 181

8

Helix

183 – 185

3

Beta strand

186 – 189

4

Helix

190 – 192

3

Beta strand

201 – 204

4

Beta strand

210 – 219

10

Helix

228 – 235

8

Helix

241 – 251

11

Beta strand

257 – 266

10

Helix

267 – 269

3

Turn

270 – 272

3

Turn

286 – 288

3

Beta strand

292 – 301

10

Helix

306 – 309

4

Turn

310 – 312

3

Helix

330 – 347

18

Helix

351 – 353

3

Helix

355 – 357

3

Turn

376 – 379

4

Beta strand

387 – 389

3

Helix

395 – 397

3

Helix

404 – 406

3

Helix

418 – 421

4

Helix

427 – 435

9

Helix

438 – 452

15

Helix

458 – 471

14

Helix

473 – 489

17

Sequences

	Sequence		Length	Mass (Da)
	P77872-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 9F029B55B73C26EA	FASTA	505	58,629
	10 20 30 40 50 60 MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI PERVVHAKGS 70 80 90 100 110 120 GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE RGSADAVRDP RGFAMKYYTE 130 140 150 160 170 180 EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK RDPQTNLPNH DMVWDFWSNV PESLYQVTWV 190 200 210 220 230 240 MSDRGIPKSF RHMDGFGSHT FSLINAKGER FWVKFHFHTM QGVKHLTNEE AAEVRKYDPD 250 260 270 280 290 300 SNQRDLFNAI ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN 310 320 330 340 350 360 KNPENYFAEV EQAAFSPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN YPQIPVNKPR 370 380 390 400 410 420 CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP KFNLAHIEKE FEVWNWDYRA 430 440 450 460 470 480 DDSDYYTQPG DYYRSLPADE KERLHDTIGE SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK 490 500 KALEKHQKMM KDMHGKDMHH TKKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An investigation of the molecular basis of the spontaneous occurrence of a catalase-negative phenotype in Helicobacter pylori." Manos J., Kolesnikow T., Hazell S.L. Helicobacter 3:28-38(1998) [PubMed: 9546115] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RU1.
[2]	"Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain." Odenbreit S., Wieland B., Haas R. J. Bacteriol. 178:6960-6967(1996) [PubMed: 8955320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: P1.
[3]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U67458 Genomic DNA. Translation: AAC16068.1.
Z70679 Genomic DNA. Translation: CAA94567.1.
AE000511 Genomic DNA. Translation: AAD07923.1.

PIR

C64629.

RefSeq

NP_207669.1.

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QWL	X-ray	1.60	A/B	1-505	[»]
1QWM	X-ray	1.60	A/B	1-505	[»]
2A9E	X-ray	1.76	A/B	1-505	[»]
2IQF	X-ray	1.86	A/B	1-505	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:3559N.

Genome annotation databases

GeneID

899404.

GenomeReviews

Gene locus HP_0875 in contig AE000511_GR.

KEGG

hpy:HP0875.

NMPDR

fig|85962.1.peg.866.

TIGR

HP_0875.

Phylogenomic databases

HOGENOM

P77872.

Family and domain databases

InterPro

IPR002226. Catalase.
IPR011614. Catalase_N.
[Graphical view]

Gene3D

G3DSA:2.40.180.10. Catalase_N. 1 hit.

PANTHER

PTHR11465. Catalase. 1 hit.

Pfam

PF00199. Catalase. 1 hit.
[Graphical view]

PRINTS

PR00067. CATALASE.

ProDom

PD000510. Catalase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

CATA_HELPY

Accession

Primary (citable) accession number: P77872
Secondary accession number(s): P94823

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)