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Protein

Catalase

Gene

katA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56PROSITE-ProRule annotation1
Active sitei129PROSITE-ProRule annotation1
Metal bindingi339Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • hydrogen peroxide catabolic process Source: CACAO
  • response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP77872.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:HP_0875
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849871 – 505CatalaseAdd BLAST505

Proteomic databases

PaxDbiP77872.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_0874O255423EBI-7585674,EBI-7585664

Protein-protein interaction databases

DIPiDIP-3559N.
IntActiP77872. 2 interactors.
MINTiMINT-165967.
STRINGi85962.HP0875.

Structurei

Secondary structure

1505
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 26Combined sources3
Helixi36 – 45Combined sources10
Beta strandi58 – 68Combined sources11
Turni73 – 75Combined sources3
Helixi79 – 81Combined sources3
Beta strandi87 – 95Combined sources9
Beta strandi105 – 109Combined sources5
Beta strandi112 – 119Combined sources8
Beta strandi122 – 132Combined sources11
Helixi139 – 141Combined sources3
Helixi142 – 149Combined sources8
Turni153 – 155Combined sources3
Helixi160 – 169Combined sources10
Helixi171 – 173Combined sources3
Helixi174 – 181Combined sources8
Helixi183 – 185Combined sources3
Beta strandi186 – 189Combined sources4
Helixi190 – 192Combined sources3
Beta strandi201 – 204Combined sources4
Beta strandi210 – 219Combined sources10
Helixi228 – 235Combined sources8
Helixi241 – 251Combined sources11
Beta strandi257 – 266Combined sources10
Helixi267 – 269Combined sources3
Turni270 – 272Combined sources3
Turni286 – 288Combined sources3
Beta strandi292 – 301Combined sources10
Helixi306 – 309Combined sources4
Turni310 – 312Combined sources3
Helixi330 – 347Combined sources18
Helixi351 – 353Combined sources3
Helixi355 – 357Combined sources3
Turni376 – 379Combined sources4
Beta strandi387 – 389Combined sources3
Helixi395 – 397Combined sources3
Helixi404 – 406Combined sources3
Helixi418 – 421Combined sources4
Helixi427 – 435Combined sources9
Helixi438 – 452Combined sources15
Helixi458 – 471Combined sources14
Helixi473 – 489Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QWLX-ray1.60A/B1-505[»]
1QWMX-ray1.60A/B1-505[»]
2A9EX-ray1.76A/B1-505[»]
2IQFX-ray1.86A/B1-505[»]
ProteinModelPortaliP77872.
SMRiP77872.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77872.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
KOiK03781.
OMAiWDYRADD.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI
60 70 80 90 100
PERVVHAKGS GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE
110 120 130 140 150
RGSADAVRDP RGFAMKYYTE EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK
160 170 180 190 200
RDPQTNLPNH DMVWDFWSNV PESLYQVTWV MSDRGIPKSF RHMDGFGSHT
210 220 230 240 250
FSLINAKGER FWVKFHFHTM QGVKHLTNEE AAEVRKYDPD SNQRDLFNAI
260 270 280 290 300
ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN
310 320 330 340 350
KNPENYFAEV EQAAFSPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN
360 370 380 390 400
YPQIPVNKPR CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP
410 420 430 440 450
KFNLAHIEKE FEVWNWDYRA DDSDYYTQPG DYYRSLPADE KERLHDTIGE
460 470 480 490 500
SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK KALEKHQKMM KDMHGKDMHH

TKKKK
Length:505
Mass (Da):58,629
Last modified:November 1, 1997 - v2
Checksum:i9F029B55B73C26EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82S → F in AAC16068 (PubMed:9546115).Curated1
Sequence conflicti234V → I in CAA94567 (PubMed:8955320).Curated1
Sequence conflicti237Y → H in CAA94567 (PubMed:8955320).Curated1
Sequence conflicti248N → D in CAA94567 (PubMed:8955320).Curated1
Sequence conflicti255F → Y in CAA94567 (PubMed:8955320).Curated1
Sequence conflicti286L → T in CAA94567 (PubMed:8955320).Curated1
Sequence conflicti313A → V in AAC16068 (PubMed:9546115).Curated1
Sequence conflicti316S → T in AAC16068 (PubMed:9546115).Curated1
Sequence conflicti316S → T in CAA94567 (PubMed:8955320).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67458 Genomic DNA. Translation: AAC16068.1.
Z70679 Genomic DNA. Translation: CAA94567.1.
AE000511 Genomic DNA. Translation: AAD07923.1.
PIRiC64629.
RefSeqiNP_207669.1. NC_000915.1.
WP_000247370.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07923; AAD07923; HP_0875.
GeneIDi899404.
KEGGiheo:C694_04480.
hpy:HP0875.
PATRICi20593039. VBIHelPyl33062_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67458 Genomic DNA. Translation: AAC16068.1.
Z70679 Genomic DNA. Translation: CAA94567.1.
AE000511 Genomic DNA. Translation: AAD07923.1.
PIRiC64629.
RefSeqiNP_207669.1. NC_000915.1.
WP_000247370.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QWLX-ray1.60A/B1-505[»]
1QWMX-ray1.60A/B1-505[»]
2A9EX-ray1.76A/B1-505[»]
2IQFX-ray1.86A/B1-505[»]
ProteinModelPortaliP77872.
SMRiP77872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3559N.
IntActiP77872. 2 interactors.
MINTiMINT-165967.
STRINGi85962.HP0875.

Proteomic databases

PaxDbiP77872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07923; AAD07923; HP_0875.
GeneIDi899404.
KEGGiheo:C694_04480.
hpy:HP0875.
PATRICi20593039. VBIHelPyl33062_0907.

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
KOiK03781.
OMAiWDYRADD.

Enzyme and pathway databases

SABIO-RKP77872.

Miscellaneous databases

EvolutionaryTraceiP77872.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_HELPY
AccessioniPrimary (citable) accession number: P77872
Secondary accession number(s): P94823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.