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P77872

- CATA_HELPY

UniProt

P77872 - CATA_HELPY

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Protein

Catalase

Gene

katA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561PROSITE-ProRule annotation
Active sitei129 – 1291PROSITE-ProRule annotation
Metal bindingi339 – 3391Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP77872.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:HP_0875
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505CatalasePRO_0000084987Add
BLAST

Proteomic databases

PRIDEiP77872.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_0874O255423EBI-7585674,EBI-7585664

Protein-protein interaction databases

DIPiDIP-3559N.
IntActiP77872. 2 interactions.
MINTiMINT-165967.
STRINGi85962.HP0875.

Structurei

Secondary structure

1
505
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 263Combined sources
Helixi36 – 4510Combined sources
Beta strandi58 – 6811Combined sources
Turni73 – 753Combined sources
Helixi79 – 813Combined sources
Beta strandi87 – 959Combined sources
Beta strandi105 – 1095Combined sources
Beta strandi112 – 1198Combined sources
Beta strandi122 – 13211Combined sources
Helixi139 – 1413Combined sources
Helixi142 – 1498Combined sources
Turni153 – 1553Combined sources
Helixi160 – 16910Combined sources
Helixi171 – 1733Combined sources
Helixi174 – 1818Combined sources
Helixi183 – 1853Combined sources
Beta strandi186 – 1894Combined sources
Helixi190 – 1923Combined sources
Beta strandi201 – 2044Combined sources
Beta strandi210 – 21910Combined sources
Helixi228 – 2358Combined sources
Helixi241 – 25111Combined sources
Beta strandi257 – 26610Combined sources
Helixi267 – 2693Combined sources
Turni270 – 2723Combined sources
Turni286 – 2883Combined sources
Beta strandi292 – 30110Combined sources
Helixi306 – 3094Combined sources
Turni310 – 3123Combined sources
Helixi330 – 34718Combined sources
Helixi351 – 3533Combined sources
Helixi355 – 3573Combined sources
Turni376 – 3794Combined sources
Beta strandi387 – 3893Combined sources
Helixi395 – 3973Combined sources
Helixi404 – 4063Combined sources
Helixi418 – 4214Combined sources
Helixi427 – 4359Combined sources
Helixi438 – 45215Combined sources
Helixi458 – 47114Combined sources
Helixi473 – 48917Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QWLX-ray1.60A/B1-505[»]
1QWMX-ray1.60A/B1-505[»]
2A9EX-ray1.76A/B1-505[»]
2IQFX-ray1.86A/B1-505[»]
ProteinModelPortaliP77872.
SMRiP77872. Positions 1-491.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77872.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiCOG0753.
KOiK03781.
OMAiEFECTED.
OrthoDBiEOG6P5Z9F.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI
60 70 80 90 100
PERVVHAKGS GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE
110 120 130 140 150
RGSADAVRDP RGFAMKYYTE EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK
160 170 180 190 200
RDPQTNLPNH DMVWDFWSNV PESLYQVTWV MSDRGIPKSF RHMDGFGSHT
210 220 230 240 250
FSLINAKGER FWVKFHFHTM QGVKHLTNEE AAEVRKYDPD SNQRDLFNAI
260 270 280 290 300
ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN
310 320 330 340 350
KNPENYFAEV EQAAFSPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN
360 370 380 390 400
YPQIPVNKPR CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP
410 420 430 440 450
KFNLAHIEKE FEVWNWDYRA DDSDYYTQPG DYYRSLPADE KERLHDTIGE
460 470 480 490 500
SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK KALEKHQKMM KDMHGKDMHH

TKKKK
Length:505
Mass (Da):58,629
Last modified:November 1, 1997 - v2
Checksum:i9F029B55B73C26EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821S → F in AAC16068. (PubMed:9546115)Curated
Sequence conflicti234 – 2341V → I in CAA94567. (PubMed:8955320)Curated
Sequence conflicti237 – 2371Y → H in CAA94567. (PubMed:8955320)Curated
Sequence conflicti248 – 2481N → D in CAA94567. (PubMed:8955320)Curated
Sequence conflicti255 – 2551F → Y in CAA94567. (PubMed:8955320)Curated
Sequence conflicti286 – 2861L → T in CAA94567. (PubMed:8955320)Curated
Sequence conflicti313 – 3131A → V in AAC16068. (PubMed:9546115)Curated
Sequence conflicti316 – 3161S → T in AAC16068. (PubMed:9546115)Curated
Sequence conflicti316 – 3161S → T in CAA94567. (PubMed:8955320)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67458 Genomic DNA. Translation: AAC16068.1.
Z70679 Genomic DNA. Translation: CAA94567.1.
AE000511 Genomic DNA. Translation: AAD07923.1.
PIRiC64629.
RefSeqiNP_207669.1. NC_000915.1.
YP_006934789.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07923; AAD07923; HP_0875.
GeneIDi13870059.
899404.
KEGGiheo:C694_04480.
hpy:HP0875.
PATRICi20593039. VBIHelPyl33062_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67458 Genomic DNA. Translation: AAC16068.1 .
Z70679 Genomic DNA. Translation: CAA94567.1 .
AE000511 Genomic DNA. Translation: AAD07923.1 .
PIRi C64629.
RefSeqi NP_207669.1. NC_000915.1.
YP_006934789.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QWL X-ray 1.60 A/B 1-505 [» ]
1QWM X-ray 1.60 A/B 1-505 [» ]
2A9E X-ray 1.76 A/B 1-505 [» ]
2IQF X-ray 1.86 A/B 1-505 [» ]
ProteinModelPortali P77872.
SMRi P77872. Positions 1-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3559N.
IntActi P77872. 2 interactions.
MINTi MINT-165967.
STRINGi 85962.HP0875.

Proteomic databases

PRIDEi P77872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07923 ; AAD07923 ; HP_0875 .
GeneIDi 13870059.
899404.
KEGGi heo:C694_04480.
hpy:HP0875.
PATRICi 20593039. VBIHelPyl33062_0907.

Phylogenomic databases

eggNOGi COG0753.
KOi K03781.
OMAi EFECTED.
OrthoDBi EOG6P5Z9F.

Enzyme and pathway databases

SABIO-RK P77872.

Miscellaneous databases

EvolutionaryTracei P77872.

Family and domain databases

Gene3Di 2.40.180.10. 1 hit.
InterProi IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view ]
PANTHERi PTHR11465. PTHR11465. 1 hit.
Pfami PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view ]
PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSi PR00067. CATALASE.
SMARTi SM01060. Catalase. 1 hit.
[Graphical view ]
SUPFAMi SSF56634. SSF56634. 1 hit.
PROSITEi PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An investigation of the molecular basis of the spontaneous occurrence of a catalase-negative phenotype in Helicobacter pylori."
    Manos J., Kolesnikow T., Hazell S.L.
    Helicobacter 3:28-38(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RU1.
  2. "Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain."
    Odenbreit S., Wieland B., Haas R.
    J. Bacteriol. 178:6960-6967(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: P1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCATA_HELPY
AccessioniPrimary (citable) accession number: P77872
Secondary accession number(s): P94823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3