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Protein

Copper-transporting ATPase

Gene

copA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably involved in copper export.

Catalytic activityi

ATP + H2O + Cu2+(Side 1) = ADP + phosphate + Cu2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12CopperPROSITE-ProRule annotation1
Metal bindingi15CopperPROSITE-ProRule annotation1
Active sitei4354-aspartylphosphate intermediateBy similarity1
Metal bindingi631MagnesiumPROSITE-ProRule annotation1
Metal bindingi635MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.4)
Gene namesi
Name:copA
OrganismiHelicobacter pylori (Campylobacter pylori)
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 124ExtracellularSequence analysisAdd BLAST20
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Topological domaini145 – 151CytoplasmicSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 343CytoplasmicSequence analysisAdd BLAST128
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Topological domaini367 – 379ExtracellularSequence analysisAdd BLAST13
Transmembranei380 – 397HelicalSequence analysisAdd BLAST18
Topological domaini398 – 685CytoplasmicSequence analysisAdd BLAST288
Transmembranei686 – 705HelicalSequence analysisAdd BLAST20
Topological domaini706 – 716ExtracellularSequence analysisAdd BLAST11
Transmembranei717 – 735HelicalSequence analysisAdd BLAST19
Topological domaini736 – 745CytoplasmicSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461711 – 745Copper-transporting ATPaseAdd BLAST745

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP77871.
SMRiP77871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 1 hit.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P77871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVNLLNKS ANIEFNENET
60 70 80 90 100
NLDEIFKLIE KLGYSPKKTL AEEKKEFFSP NVKLALAVIF TLFVVYLSMG
110 120 130 140 150
AMLSPSLLPK SLLAIDNHSN FLNACLQLIG TLIVMHWGRD FYIQGFKALW
160 170 180 190 200
HRQPNMSSLI AIGTSAALIS SLWQLYLVYT DHYTDQWSYG HYYFESVCVI
210 220 230 240 250
LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKIQNDQ QIEVLVDSIV
260 270 280 290 300
VGDILKVLPG TLIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT
310 320 330 340 350
FNSHTSFLMK ATQNNKNSTL SQIVEMIHNA QSSKAEISRL ADKVSSVFVP
360 370 380 390 400
SVIAIAILAF VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATL
410 420 430 440 450
MSILVANQKA SSLGLFFKDA KSLEKARLVN TIVFDKTGTL TNGKPVVKSV
460 470 480 490 500
HSKIELLELL SLANSIEKSS EHVIAKGIVE YAKEHNAPLK EMSEVKVKTG
510 520 530 540 550
FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIQENGILVL VGRAINEKED
560 570 580 590 600
ELLGAFVLED LPKKGVKEHV AQIKNLGINT FLLSGDNREN VKKCALELGI
610 620 630 640 650
DGYISNAKPQ DKLNKIKELK EKGRIVMMVG DGLNDAPSLA MSDVAVVMAK
660 670 680 690 700
GSDVSVQAAD IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI
710 720 730 740
PLACGVLYKA NIMLSPAIAG LAMSLSSVSV VLNSQRLRNF KIKDH
Length:745
Mass (Da):82,029
Last modified:December 1, 2000 - v2
Checksum:i043168CF0622245B
GO

Sequence cautioni

The sequence AAB67320 differs from that shown. Reason: Frameshift at positions 393, 400, 410, 416, 537 and 539.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33259 Genomic DNA. Translation: AAB67320.1. Frameshift.

Similar proteinsi

Entry informationi

Entry nameiCOPA1_HELPX
AccessioniPrimary (citable) accession number: P77871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: July 5, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families