Probable cation-transporting ATPase HI_0290 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Probable cation-transporting ATPase HI_0290
EC=3.6.3.-

Gene names

Ordered Locus Names:

HI_0290

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	722 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity

ATP + H₂O = ADP + phosphate.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 1 HMA domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 722

722

Probable cation-transporting ATPase HI_0290

PRO_0000046334

Regions

Transmembrane

94 – 114

21

Helical; Potential

Transmembrane

118 – 138

21

Helical; Potential

Transmembrane

157 – 177

21

Helical; Potential

Transmembrane

180 – 200

21

Helical; Potential

Transmembrane

340 – 360

21

Helical; Potential

Transmembrane

373 – 393

21

Helical; Potential

Transmembrane

523 – 543

21

Helical; Potential

Transmembrane

608 – 628

21

Helical; Potential

Transmembrane

675 – 695

21

Helical; Potential

Transmembrane

697 – 717

21

Helical; Potential

Domain

10 – 76

67

HMA

Sites

Active site

422

1

4-aspartylphosphate intermediate By similarity

Metal binding

20

1

Potential

Metal binding

23

1

Potential

Metal binding

617

1

Magnesium By similarity

Metal binding

621

1

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P77868 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E4FF0BA5642EDCDD
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FASTA

722

78,072

        10         20         30         40         50         60 
MLDLTPQSKK ISIQIGGMTC QSCANRIEKV LNKKPFVQQA GVNFAAEEAQ VVFDATQASE 

        70         80         90        100        110        120 
AQIIEIIHKT GFSAHIKQAN ELPIEENTSI PWRLIVLWII NIPFLIGMLG MIGGSHNLML 

       130        140        150        160        170        180 
PPIWQFALAS IVQLWLAIPF YRGAIGSIRG GLTNMDVLVS TGTLTIYLYS AFMLFYHANH 

       190        200        210        220        230        240 
AMGHVYFEAS VMVIGFVSLG KFLEDRTKKH SLNSLSMLLQ LTPKKVTVLR NEKWIEIALD 

       250        260        270        280        290        300 
QVNIGEIIRA NQGERIAADG VIESGNGWCD ESHLTGESRP EEKQKGGKVL AGAMVTEGSI 

       310        320        330        340        350        360 
IYRANQLGSQ TLLGDMMNAL SDAQGSKAPI ARFADKVTSV FVPVVLVISL VTFALTYILT 

       370        380        390        400        410        420 
NDSVSSLIHA VSVLVIACPC ALGLATPAAI MVGLGKAVNA GVWFKDAAAM EETAHVDTVV 

       430        440        450        460        470        480 
LDKTGTLTKG ELEISALWQP QSAVYSEDDL YRFAAAVERQ ANHPIAKAIV QAAEXKMLEI 

       490        500        510        520        530        540 
PTALFSKMEV GQGIQAELEQ VGTIKVGKPD YCGLILPKNL EDIWQIASIV AVSINDEPIG 

       550        560        570        580        590        600 
AFALTDTLKN DSLHAIQRLQ QQNIDVVIMS GDQQSVVDYI AKQLGIKKAF GKLTPRDKAE 

       610        620        630        640        650        660 
QIQKLKDLGH IVAMVGDGIN DAPALASANV SFAMKSSSDI AEQTASATLM QHSVNQLVDA 

       670        680        690        700        710        720 
LFIARATLKN IKQNLFFALI YNILGIPLAA FGFLSPIIAG AAMALSSISV LMNALRLKKV 


RF

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21955.1.
RefSeq	NP_438457.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P77868.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949726.
GenomeReviews	Gene locus HI_0290 in contig L42023_GR.
KEGG	hin:HI0290.
NMPDR	fig\|71421.1.peg.272.
PATRIC	20189119. VBIHaeInf48452_0306.
TIGR	HI_0290.
Phylogenomic databases
HOGENOM	HBG507745.
OMA	AYGHTHE.
PhylomeDB	P77868.
ProtClustDB	CLSK870654.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0290-MONOMER.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K01533.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 1 hit.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y290_HAEIN

Accession

Primary (citable) accession number: P77868

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents