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Protein

Hydrogenase-4 component C

Gene

hyfC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • oxidation-reduction process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-154.
ECOL316407:JW2468-MONOMER.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component C (EC:1.-.-.-)
Gene namesi
Name:hyfC
Ordered Locus Names:b2483, JW2468
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14211. hyfC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10PeriplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 73CytoplasmicSequence analysisAdd BLAST42
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 98PeriplasmicSequence analysis4
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 140CytoplasmicSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 181PeriplasmicSequence analysisAdd BLAST20
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 228CytoplasmicSequence analysisAdd BLAST26
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 256PeriplasmicSequence analysis7
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 289CytoplasmicSequence analysisAdd BLAST12
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 315PeriplasmicSequence analysis5

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001175351 – 315Hydrogenase-4 component CAdd BLAST315

Proteomic databases

PaxDbiP77858.
PRIDEiP77858.

Interactioni

Protein-protein interaction databases

BioGridi4259197. 5 interactors.
STRINGi511145.b2483.

Structurei

3D structure databases

ProteinModelPortaliP77858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107TDF. Bacteria.
COG0650. LUCA.
HOGENOMiHOG000228277.
InParanoidiP77858.
KOiK12138.
OMAiAKMHSRQ.
PhylomeDBiP77858.

Family and domain databases

InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQTLCDGYL VIFALAQAVI LLMLTPLFTG ISRQIRARMH SRRGPGIWQD
60 70 80 90 100
YRDIHKLFKR QEVAPTSSGL MFRLMPWVLI SSMLVLAMAL PLFITVSPFA
110 120 130 140 150
GGGDLITLIY LLALFRFFFA LSGLDTGSPF AGVGASRELT LGILVEPMLI
160 170 180 190 200
LSLLVLALIA GSTHIEMISN TLAMGWNSPL TTVLALLACG FACFIEMGKI
210 220 230 240 250
PFDVAEAEQE LQEGPLTEYS GAGLALAKWG LGLKQVVMAS LFVALFLPFG
260 270 280 290 300
RAQELSLACL LTSLVVTLLK VLLIFVLASI AENTLARGRF LLIHHVTWLG
310
FSLAALAWVF WLTGL
Length:315
Mass (Da):34,359
Last modified:February 1, 1997 - v1
Checksum:i18B2988ED37DD1C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88565.1.
U00096 Genomic DNA. Translation: AAC75536.2.
AP009048 Genomic DNA. Translation: BAA16361.2.
PIRiB65024.
RefSeqiNP_416978.4. NC_000913.3.
WP_001311024.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75536; AAC75536; b2483.
BAA16361; BAA16361; BAA16361.
GeneIDi947492.
KEGGiecj:JW2468.
eco:b2483.
PATRICi32120353. VBIEscCol129921_2579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88565.1.
U00096 Genomic DNA. Translation: AAC75536.2.
AP009048 Genomic DNA. Translation: BAA16361.2.
PIRiB65024.
RefSeqiNP_416978.4. NC_000913.3.
WP_001311024.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259197. 5 interactors.
STRINGi511145.b2483.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP77858.
PRIDEiP77858.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75536; AAC75536; b2483.
BAA16361; BAA16361; BAA16361.
GeneIDi947492.
KEGGiecj:JW2468.
eco:b2483.
PATRICi32120353. VBIEscCol129921_2579.

Organism-specific databases

EchoBASEiEB3963.
EcoGeneiEG14211. hyfC.

Phylogenomic databases

eggNOGiENOG4107TDF. Bacteria.
COG0650. LUCA.
HOGENOMiHOG000228277.
InParanoidiP77858.
KOiK12138.
OMAiAKMHSRQ.
PhylomeDBiP77858.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-154.
ECOL316407:JW2468-MONOMER.

Miscellaneous databases

PROiP77858.

Family and domain databases

InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYFC_ECOLI
AccessioniPrimary (citable) accession number: P77858
Secondary accession number(s): P78262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.