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Protein

Hydrogenase-4 component C

Gene

hyfC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible component of hydrogenase 4.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-154

Protein family/group databases

TCDBi3.D.1.9.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component C (EC:1.-.-.-)
Gene namesi
Name:hyfC1 Publication
Ordered Locus Names:b2483, JW2468
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14211 hyfC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10PeriplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 73CytoplasmicSequence analysisAdd BLAST42
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 98PeriplasmicSequence analysis4
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 140CytoplasmicSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 181PeriplasmicSequence analysisAdd BLAST20
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 228CytoplasmicSequence analysisAdd BLAST26
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 256PeriplasmicSequence analysis7
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 289CytoplasmicSequence analysisAdd BLAST12
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 315PeriplasmicSequence analysis1 Publication5

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001175351 – 315Hydrogenase-4 component CAdd BLAST315

Proteomic databases

PaxDbiP77858
PRIDEiP77858

Interactioni

Protein-protein interaction databases

BioGridi4259197, 10 interactors
STRINGi316385.ECDH10B_2649

Structurei

3D structure databases

ProteinModelPortaliP77858
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107TDF Bacteria
COG0650 LUCA
HOGENOMiHOG000228277
InParanoidiP77858
KOiK12138
OMAiMRIFRVP
PhylomeDBiP77858

Family and domain databases

InterProiView protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS
PfamiView protein in Pfam
PF00146 NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00668 COMPLEX1_ND1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P77858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQTLCDGYL VIFALAQAVI LLMLTPLFTG ISRQIRARMH SRRGPGIWQD
60 70 80 90 100
YRDIHKLFKR QEVAPTSSGL MFRLMPWVLI SSMLVLAMAL PLFITVSPFA
110 120 130 140 150
GGGDLITLIY LLALFRFFFA LSGLDTGSPF AGVGASRELT LGILVEPMLI
160 170 180 190 200
LSLLVLALIA GSTHIEMISN TLAMGWNSPL TTVLALLACG FACFIEMGKI
210 220 230 240 250
PFDVAEAEQE LQEGPLTEYS GAGLALAKWG LGLKQVVMAS LFVALFLPFG
260 270 280 290 300
RAQELSLACL LTSLVVTLLK VLLIFVLASI AENTLARGRF LLIHHVTWLG
310
FSLAALAWVF WLTGL
Length:315
Mass (Da):34,359
Last modified:February 1, 1997 - v1
Checksum:i18B2988ED37DD1C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA Translation: AAB88565.1
U00096 Genomic DNA Translation: AAC75536.2
AP009048 Genomic DNA Translation: BAA16361.2
PIRiB65024
RefSeqiNP_416978.4, NC_000913.3
WP_001311024.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75536; AAC75536; b2483
BAA16361; BAA16361; BAA16361
GeneIDi947492
KEGGiecj:JW2468
eco:b2483
PATRICifig|1411691.4.peg.4256

Similar proteinsi

Entry informationi

Entry nameiHYFC_ECOLI
AccessioniPrimary (citable) accession number: P77858
Secondary accession number(s): P78262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health