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Reviewed, UniProtKB/Swiss-Prot P77858 (HYFC_ECOLI)

Last modified June 16, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hydrogenase-4 component C
    EC=1.-.-.-
Gene names
Name: hyfC
Ordered Locus Names: b2483, JW2468
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the complex I subunit 1 family.

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Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Hydrogenase-4 component C
PRO_0000117535

Regions

Topological domain1 – 1010Periplasmic Potential
Transmembrane11 – 3121 Potential
Topological domain32 – 7342Cytoplasmic Potential
Transmembrane74 – 9421 Potential
Topological domain95 – 984Periplasmic Potential
Transmembrane99 – 11921 Potential
Topological domain120 – 14021Cytoplasmic Potential
Transmembrane141 – 16121 Potential
Topological domain162 – 18120Periplasmic Potential
Transmembrane182 – 20221 Potential
Topological domain203 – 22826Cytoplasmic Potential
Transmembrane229 – 24921 Potential
Topological domain250 – 2567Periplasmic Potential
Transmembrane257 – 27721 Potential
Topological domain278 – 28912Cytoplasmic Potential
Transmembrane290 – 31021 Potential
Topological domain311 – 3155Periplasmic Potential

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Sequences

Sequence LengthMass (Da)Tools
P77858-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 18B2988ED37DD1C9

FASTA31534,359
        10         20         30         40         50         60 
MRQTLCDGYL VIFALAQAVI LLMLTPLFTG ISRQIRARMH SRRGPGIWQD YRDIHKLFKR 

        70         80         90        100        110        120 
QEVAPTSSGL MFRLMPWVLI SSMLVLAMAL PLFITVSPFA GGGDLITLIY LLALFRFFFA 

       130        140        150        160        170        180 
LSGLDTGSPF AGVGASRELT LGILVEPMLI LSLLVLALIA GSTHIEMISN TLAMGWNSPL 

       190        200        210        220        230        240 
TTVLALLACG FACFIEMGKI PFDVAEAEQE LQEGPLTEYS GAGLALAKWG LGLKQVVMAS 

       250        260        270        280        290        300 
LFVALFLPFG RAQELSLACL LTSLVVTLLK VLLIFVLASI AENTLARGRF LLIHHVTWLG 

       310 
FSLAALAWVF WLTGL

« Hide

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References

« Hide 'large scale' references
[1]Andrews S.C., McClay J., Ambler A., Quail M., Berks B.C., Guest J.R.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. expand/collapse author list , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
DNA Res. 4:91-113(1997) [PubMed: 9205837] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

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Cross-references

Sequence databases

M63654 Genomic DNA. Translation: AAB88565.1.
U00096 Genomic DNA. Translation: AAC75536.1. Different initiation.
AP009048 Genomic DNA. Translation: BAA16361.2.
PIRB65024.
RefSeqAP_003069.1.
NP_416978.4.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID947492.
GenomeReviewsGene locus JW2468 in contig AP009048_GR.
Gene locus b2483 in contig U00096_GR.
KEGGecj:JW2468.
eco:b2483.

Organism-specific databases

EchoBASEEB3963.
EcoGeneEG14211. hyfC.
CMRSearch...

Phylogenomic databases

HOGENOMP77858.
OMAP77858. QVVMAAL.

Enzyme and pathway databases

BioCycEcoCyc:MON0-154.

Family and domain databases

InterProIPR001694. NADH_UbQ_OxRdtase_su1.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERPTHR11432. Resp_NADH_DH_1. 1 hit.
PfamPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEPS00667. COMPLEX1_ND1_1. False negative.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHYFC_ECOLI
AccessionPrimary (citable) accession number: P77858
Secondary accession number(s): P78262
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents