Reviewed, UniProtKB/Swiss-Prot P77845 (ACKA_CORGL)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Synonyms:	ack
Ordered Locus Names:	Cgl2752, cg3047

Organism

Corynebacterium glutamicum (Brevibacterium flavum) [Complete proteome] [HAMAP]

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the activation of acetate to acetyl CoA and the secretion of acetate By similarity.
Catalytic activity	ATP + acetate = ADP + acetyl phosphate. ATP + propanoate = ADP + propanoyl phosphate.
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 397	397	Acetate kinase

Sequences

	Sequence		Length	Mass (Da)
	P77845-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 248FF97A3C52B0E4	FASTA	397	43,092
	10 20 30 40 50 60 MALALVLNSG SSSIKFQLVN PENSAIDEPY VSGLVEQIGE PNGRIVLKIE GEKYTLETPI 70 80 90 100 110 120 ADHSEGLNLA FDLMDQHNCG PSQLEITAVG HRVVHGGILF SAPELITDEI VEMIRDLIPL 130 140 150 160 170 180 APLHNPANVD GIDVARKILP DVPHVAVFDT GFFHSLPPAA ALYAINKDVA AEHGIRRYGF 190 200 210 220 230 240 HGTSHEFVSK RVVEILEKPT EDINTITFHL GNGASMAAVQ GGRAVDTSMG MTPLAGLVMG 250 260 270 280 290 300 TRSGDIDPGI VFHLSRTAGM SIDEIDNLLN KKSGVKGLSG VNDFRELREM IDNNDQDAWS 310 320 330 340 350 360 AYNIYIHQLR RYLGSYMVAL GRVDTIVFTA GVGENAQFVR EDALAGLEMY GIEIDPERNA 370 380 390 LPNDGPRLIS TDASKVKVFV IPTNEELAIA RYAVKFA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase." Reinscheid D.J., Schnicke S., Rittmann D., Zahnow U., Sahm H., Eikmanns B.J. Microbiology 145:503-513(1999) [PubMed: 10075432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]	"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]	"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X89084 Genomic DNA. Translation: CAA61456.1. BA000036 Genomic DNA. Translation: BAC00146.1. BX927156 Genomic DNA. Translation: CAF20774.1.
RefSeq	NP_601947.1. YP_226990.1.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBase	Search...
2-D gel databases
World-2DPAGE	0001:P77845.
Genome annotation databases
GeneID	1020697. 3344522.
GenomeReviews	Gene locus cg3047 in contig BX927147_GR. Gene locus Cgl2752 in contig BA000036_GR.
KEGG	cgb:cg3047. cgl:NCgl2656.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P77845.
Enzyme and pathway databases
BioCyc	CGLU196627-1:CG3047-MON.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProDom	P77845. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACKA_CORGL

Accession

Primary (citable) accession number: P77845

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	July 22, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)