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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:Cgl2753, cg3048
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Phosphate acetyltransferasePRO_0000179128Add
BLAST

Expressioni

Inductioni

Activated by RamA and repressed by RipA and RamB.3 Publications

Interactioni

Protein-protein interaction databases

STRINGi196627.cg3048.

Structurei

3D structure databases

ProteinModelPortaliP77844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053796.
KOiK13788.
OMAiYEGFEEM.
OrthoDBiEOG6BKJ5W.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

P77844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAELFENWL LKRARAEHSH IVLPEGDDDR ILMAAHQLLD QDICDITILG
60 70 80 90 100
DPVKIKERAT ELGLHLNTAY LVNPLTDPRL EEFAEQFAEL RKSKSVTIDE
110 120 130 140 150
AREIMKDISY FGTMMVHNGD ADGMVSGAAN TTAHTIKPSF QIIKTVPEAS
160 170 180 190 200
VVSSIFLMVL RGRLWAFGDC AVNPNPTAEQ LGEIAVVSAK TAAQFGIDPR
210 220 230 240 250
VAILSYSTGN SGGGSDVDRA IDALAEARRL NPELCVDGPL QFDAAVDPGV
260 270 280 290 300
ARKKMPDSDV AGQANVFIFP DLEAGNIGYK TAQRTGHALA VGPILQGLNK
310 320
PVNDLSRGAT VPDIVNTVAI TAIQAGGRS
Length:329
Mass (Da):35,238
Last modified:February 1, 1997 - v1
Checksum:iEE6E8C6F95432E06
GO

Sequence cautioni

The sequence CAF20775.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89084 Genomic DNA. Translation: CAA61455.1.
BA000036 Genomic DNA. Translation: BAC00147.1.
BX927156 Genomic DNA. Translation: CAF20775.1. Different initiation.
RefSeqiNP_601948.1. NC_003450.3.
YP_226991.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAC00147; BAC00147; BAC00147.
CAF20775; CAF20775; cg3048.
GeneIDi1020698.
KEGGicgb:cg3048.
cgl:NCgl2657.
PATRICi21497544. VBICorGlu203724_2684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89084 Genomic DNA. Translation: CAA61455.1.
BA000036 Genomic DNA. Translation: BAC00147.1.
BX927156 Genomic DNA. Translation: CAF20775.1. Different initiation.
RefSeqiNP_601948.1. NC_003450.3.
YP_226991.1. NC_006958.1.

3D structure databases

ProteinModelPortaliP77844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg3048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC00147; BAC00147; BAC00147.
CAF20775; CAF20775; cg3048.
GeneIDi1020698.
KEGGicgb:cg3048.
cgl:NCgl2657.
PATRICi21497544. VBICorGlu203724_2684.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053796.
KOiK13788.
OMAiYEGFEEM.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase."
    Reinscheid D.J., Schnicke S., Rittmann D., Zahnow U., Sahm H., Eikmanns B.J.
    Microbiology 145:503-513(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. "RamB, a novel transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum."
    Gerstmeir R., Cramer A., Dangel P., Schaffer S., Eikmanns B.J.
    J. Bacteriol. 186:2798-2809(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  5. "The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR."
    Wennerhold J., Krug A., Bott M.
    J. Biol. Chem. 280:40500-40508(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  6. "Identification of RamA, a novel LuxR-type transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum."
    Cramer A., Gerstmeir R., Schaffer S., Bott M., Eikmanns B.J.
    J. Bacteriol. 188:2554-2567(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPTAS_CORGL
AccessioniPrimary (citable) accession number: P77844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.