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Protein

Urease subunit alpha

Gene

ureC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation2 Publications

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi139Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi220Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi220Nickel 2; via carbamate groupUniRule annotation1
Binding sitei222SubstrateUniRule annotation1
Metal bindingi249Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi275Nickel 2; via tele nitrogenUniRule annotation1
Active sitei323Proton donorUniRule annotation1
Metal bindingi363Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nickel

Enzyme and pathway databases

BioCyciBSUB:BSU36640-MONOMER
UniPathwayiUPA00258; UER00370

Protein family/group databases

MEROPSiM38.982

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:BSU36640
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675381 – 569Urease subunit alphaAdd BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Proteomic databases

PaxDbiP77837
PRIDEiP77837

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019806

Structurei

3D structure databases

ProteinModelPortaliP77837
SMRiP77837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 569UreaseUniRule annotationAdd BLAST438

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM Bacteria
COG0804 LUCA
HOGENOMiHOG000075064
InParanoidiP77837
KOiK01428
OMAiGFDSHIH
PhylomeDBiP77837

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P77837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMSREEYAE LFGPTTGDKI RLGDTDLWIE VEKDFTVYGE EMIFGGGKTI
60 70 80 90 100
RDGMGQNGRI TGKDGALDLV ITNVVLLDYT GIVKADVGVK DGRIVGVGKS
110 120 130 140 150
GNPDIMDGVD PHMVIGAGTE VISGEGKILT AGGVDTHIHF ICPQQMEVAL
160 170 180 190 200
SSGVTTLLGG GTGPATGSKA TTCTSGAWYM ARMLEAAEEF PINVGFLGKG
210 220 230 240 250
NASDKAPLIE QVEAGAIGLK LHEDWGTTPS AIKTCMEVVD EADIQVAIHT
260 270 280 290 300
DTINEAGFLE NTLDAIGDRV IHTYHIEGAG GGHAPDIMKL ASYANILPSS
310 320 330 340 350
TTPTIPYTVN TMDEHLDMMM VCHHLDAKVP EDVAFSHSRI RAATIAAEDI
360 370 380 390 400
LHDIGAISMT SSDSQAMGRV GEVIIRTWQV ADKMKKQRGA LAGENGNDNV
410 420 430 440 450
RAKRYIAKYT INPAITHGLS HEVGSVEKGK LADLVLWDPV FFGVKPELVL
460 470 480 490 500
KGGMIARAQM GDPNASIPTP EPVFMRQMYA SYGKANRSTS ITFMSQASIE
510 520 530 540 550
RGVAESLGLE KRISPVKNIR KLSKLDMKLN SALPKIEIDP KTYQVFADGE
560
ELSCQPVDYV PLGQRYFLF
Length:569
Mass (Da):61,187
Last modified:February 1, 1997 - v1
Checksum:iA2712A6172DA5BE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08559 Genomic DNA Translation: CAA69859.1
AL009126 Genomic DNA Translation: CAB15681.1
PIRiD69729
RefSeqiNP_391545.1, NC_000964.3
WP_003243090.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15681; CAB15681; BSU36640
GeneIDi936958
KEGGibsu:BSU36640
PATRICifig|224308.179.peg.3965

Similar proteinsi

Entry informationi

Entry nameiURE1_BACSU
AccessioniPrimary (citable) accession number: P77837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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