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Protein

Xylose isomerase

Gene

xylA

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99By similarity1
Active sitei102By similarity1
Metal bindingi230Magnesium 1By similarity1
Metal bindingi266Magnesium 1By similarity1
Metal bindingi266Magnesium 2By similarity1
Metal bindingi269Magnesium 2By similarity1
Metal bindingi294Magnesium 1By similarity1
Metal bindingi305Magnesium 2By similarity1
Metal bindingi307Magnesium 2By similarity1
Metal bindingi337Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BLi04048, BL03867
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957631 – 448Xylose isomeraseAdd BLAST448

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi279010.BLi04048.

Structurei

3D structure databases

ProteinModelPortaliP77832.
SMRiP77832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFRNIGMIE YEGADSENPY AFKYYNPDEF VGGKTMKEHL RFAVAYWHTF
60 70 80 90 100
DADGKDPFGD GTMFRAWNRL THPLDKAKAR AEAAFEFFEK LGVPYFCFHD
110 120 130 140 150
VDIVDEGATL RETFTYLDQM SSFLKEMMET SHVQLLWNTA NMFTHPRYVH
160 170 180 190 200
GAATSCNADV YAYAAAKVKK GLDIAKELGA ENYVFWGGRE GYETLLNTDM
210 220 230 240 250
KLELENLSSF YRMAVEYARE IGFDGQFLIE PKPKEPTKHQ YDFDAATTIA
260 270 280 290 300
FLETYGLKDH FKLNLEANHA TLAGHTFEHE LRVAALHDML GSIDANQGDL
310 320 330 340 350
LLGWDTDEFP TDLYSAVLAM YEILKAGGFK TGGINFDAKV RRPSFADEDL
360 370 380 390 400
FHAHIAGMDT YAVGLKVASR LLEDKALDQV IEERYESYTK GIGLEIKEGR
410 420 430 440
TDLKKLAAYA LENDHIENQS GRQERLKATV NRYLLNALRE APAGKETH
Length:448
Mass (Da):50,905
Last modified:February 1, 1997 - v1
Checksum:iF5769B6C12F452C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80222 Genomic DNA. Translation: CAB02314.1.
X57601 Genomic DNA. Translation: CAA40827.1.
AE017333 Genomic DNA. Translation: AAU42861.1.
CP000002 Genomic DNA. Translation: AAU25489.1.
RefSeqiWP_011198415.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU25489; AAU25489; BL03867.
AAU42861; AAU42861; BLi04048.
GeneIDi3030684.
KEGGibld:BLi04048.
bli:BL03867.
PATRICi18953908. VBIBacLic203714_4129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80222 Genomic DNA. Translation: CAB02314.1.
X57601 Genomic DNA. Translation: CAA40827.1.
AE017333 Genomic DNA. Translation: AAU42861.1.
CP000002 Genomic DNA. Translation: AAU25489.1.
RefSeqiWP_011198415.1. NC_006322.1.

3D structure databases

ProteinModelPortaliP77832.
SMRiP77832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi04048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25489; AAU25489; BL03867.
AAU42861; AAU42861; BLi04048.
GeneIDi3030684.
KEGGibld:BLi04048.
bli:BL03867.
PATRICi18953908. VBIBacLic203714_4129.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_BACLD
AccessioniPrimary (citable) accession number: P77832
Secondary accession number(s): Q65DK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.