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P77832 (XYLA_BACLD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylose isomerase
EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:BLi04048, BL03867
OrganismBacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]
Taxonomic identifier279010 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455

Subunit structure

Homotetramer By similarity. HAMAP MF_00455

Subcellular location

Cytoplasm HAMAP MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylose isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Xylose isomerase HAMAP MF_00455
PRO_0000195763

Sites

Active site991 By similarity
Active site1021 By similarity
Metal binding2301Magnesium 1 By similarity
Metal binding2661Magnesium 1 By similarity
Metal binding2661Magnesium 2 By similarity
Metal binding2691Magnesium 2 By similarity
Metal binding2941Magnesium 1 By similarity
Metal binding3051Magnesium 2 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3371Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
P77832 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F5769B6C12F452C5

FASTA44850,905
        10         20         30         40         50         60 
MFFRNIGMIE YEGADSENPY AFKYYNPDEF VGGKTMKEHL RFAVAYWHTF DADGKDPFGD 

        70         80         90        100        110        120 
GTMFRAWNRL THPLDKAKAR AEAAFEFFEK LGVPYFCFHD VDIVDEGATL RETFTYLDQM 

       130        140        150        160        170        180 
SSFLKEMMET SHVQLLWNTA NMFTHPRYVH GAATSCNADV YAYAAAKVKK GLDIAKELGA 

       190        200        210        220        230        240 
ENYVFWGGRE GYETLLNTDM KLELENLSSF YRMAVEYARE IGFDGQFLIE PKPKEPTKHQ 

       250        260        270        280        290        300 
YDFDAATTIA FLETYGLKDH FKLNLEANHA TLAGHTFEHE LRVAALHDML GSIDANQGDL 

       310        320        330        340        350        360 
LLGWDTDEFP TDLYSAVLAM YEILKAGGFK TGGINFDAKV RRPSFADEDL FHAHIAGMDT 

       370        380        390        400        410        420 
YAVGLKVASR LLEDKALDQV IEERYESYTK GIGLEIKEGR TDLKKLAAYA LENDHIENQS 

       430        440 
GRQERLKATV NRYLLNALRE APAGKETH

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, structure, promoters and regulatory elements for transcription of the Bacillus licheniformis encoded regulon for xylose utilization."
Scheler A., Rygus T., Allmansberger R., Hillen W.
Arch. Microbiol. 155:526-534(1991) [PubMed: 1953294] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Schmiedel D.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13 / ATCC 14580.
[4]"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species."
Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. expand/collapse author list , Galleron N., Ehrlich S.D., Berka R.M.
Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13 / ATCC 14580.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z80222 Genomic DNA. Translation: CAB02314.1.
X57601 Genomic DNA. Translation: CAA40827.1.
AE017333 Genomic DNA. Translation: AAU42861.1.
CP000002 Genomic DNA. Translation: AAU25489.1.
RefSeqYP_081127.1. NC_006270.3.
YP_093554.1. NC_006322.1.

3D structure databases

ProteinModelPortalP77832.
SMRP77832. Positions 2-435.
ModBaseSearch...

Protein-protein interaction databases

STRINGP77832.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000054826; EBBACP00000053357; EBBACG00000054817.
EBBACT00000060117; EBBACP00000058550; EBBACG00000060108.
GeneID3030684.
3101267.
GenomeReviewsGene locus BLi04048 in contig AE017333_GR.
Gene locus BL03867 in contig CP000002_GR.
KEGGbld:BLi04048.
bli:BL03867.
NMPDRfig|279010.5.peg.3169.
PATRIC18953908. VBIBacLic203714_4129.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2115.
GeneTreeEBGT00050000002648.
HOGENOMHBG297199.
OMALLGWDTD.
ProtClustDBPRK05474.

Enzyme and pathway databases

BioCycBLIC279010-1:BLI04048-MONOMER.
BLIC279010:BL03867-MONOMER.

Family and domain databases

HAMAPMF_00455. Xylose_isom_A.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KOK01805.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR02630. Xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_BACLD
AccessionPrimary (citable) accession number: P77832
Secondary accession number(s): Q65DK3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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