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P77809

- G6PD_AGGAC

UniProt

P77809 - G6PD_AGGAC

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461NADPUniRule annotation
    Binding sitei150 – 1501NADPUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Binding sitei237 – 2371SubstrateUniRule annotation
    Active sitei242 – 2421Proton acceptorUniRule annotation
    Binding sitei342 – 3421SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
    Taxonomic identifieri714 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Glucose-6-phosphate 1-dehydrogenasePRO_0000068108Add
    BLAST

    Proteomic databases

    PRIDEiP77809.

    Structurei

    3D structure databases

    ProteinModelPortaliP77809.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P77809-1 [UniParc]FASTAAdd to Basket

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    MKAENCCIVI FGASGDLTYR KLIPALYNLY KIDRLGEDFS VLGVARTELN    50
    DKSFREKMRQ TLIKNEGAKG ECLEQFCSHL YYQAVNTADK ADYAKLVPRL 100
    DELHDTYRTE GNTLYYLSTP PSLYGVIPEC LGEHGLNKED RGWKRLIVEK 150
    PFGYDRETAE ALDIQIHRFF EEHQIYRIDH YLGKETVQNL LVLRFSNGWF 200
    EPLWNRNFID YIEITGAESI GVEERGGYYD GSGAMRDMFQ NHLLQVLAMV 250
    AMEPPVIINA NSMRDEVAKV LHCLRPLTQE DVEHNLVLGQ YVAGEVDGEW 300
    VKGYLEEKGV PPYSTTETYM ALRCEIENWR WAGVPFYVRT GKRLPARVTE 350
    IVIHFKTTPH PVFSQNAPEN KLIIRIQPDE GISMRFGLKK PGAGFEAKEV 400
    SMDFRYADLA GATVMTAYER LLLDAMKGDA TLFARTDAVH AAWKFVQPIL 450
    NYKAQGGRLY DYEAGTWGPT AADKLIAKSG RVWRRPSGLM KKKV 494
    Length:494
    Mass (Da):56,385
    Last modified:February 1, 1997 - v1
    Checksum:iB0B2A32F349936A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88189 Genomic DNA. Translation: BAA13554.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88189 Genomic DNA. Translation: BAA13554.1 .

    3D structure databases

    ProteinModelPortali P77809.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P77809.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
      Yoshida Y., Nakano Y., Yamashita Y., Koga T.
      Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43718 / FDC Y4 / Serotype b.

    Entry informationi

    Entry nameiG6PD_AGGAC
    AccessioniPrimary (citable) accession number: P77809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3