Reviewed, UniProtKB/Swiss-Prot P77809 (G6PD_AGGAC)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:

zwf

Organism

Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)

Taxonomic identifier

714 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Aggregatibacter

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068108
Sites
	Active site	242	1	Proton acceptor By similarity
	Binding site	14	1	NADP By similarity
	Binding site	46	1	NADP By similarity
	Binding site	180	1	Substrate By similarity
	Binding site	184	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P77809-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: B0B2A32F349936A2	FASTA	494	56,385
	10 20 30 40 50 60 MKAENCCIVI FGASGDLTYR KLIPALYNLY KIDRLGEDFS VLGVARTELN DKSFREKMRQ 70 80 90 100 110 120 TLIKNEGAKG ECLEQFCSHL YYQAVNTADK ADYAKLVPRL DELHDTYRTE GNTLYYLSTP 130 140 150 160 170 180 PSLYGVIPEC LGEHGLNKED RGWKRLIVEK PFGYDRETAE ALDIQIHRFF EEHQIYRIDH 190 200 210 220 230 240 YLGKETVQNL LVLRFSNGWF EPLWNRNFID YIEITGAESI GVEERGGYYD GSGAMRDMFQ 250 260 270 280 290 300 NHLLQVLAMV AMEPPVIINA NSMRDEVAKV LHCLRPLTQE DVEHNLVLGQ YVAGEVDGEW 310 320 330 340 350 360 VKGYLEEKGV PPYSTTETYM ALRCEIENWR WAGVPFYVRT GKRLPARVTE IVIHFKTTPH 370 380 390 400 410 420 PVFSQNAPEN KLIIRIQPDE GISMRFGLKK PGAGFEAKEV SMDFRYADLA GATVMTAYER 430 440 450 460 470 480 LLLDAMKGDA TLFARTDAVH AAWKFVQPIL NYKAQGGRLY DYEAGTWGPT AADKLIAKSG 490 RVWRRPSGLM KKKV

References

[1]

"The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA." Yoshida Y., Nakano Y., Yamashita Y., Koga T. Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed: 9020051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43718 / FDC Y4 / Serotype b.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88189 Genomic DNA. Translation: BAA13554.1.
3D structure databases
SMR	P77809. Positions 2-486.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.49. 164755.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_AGGAC

Accession

Primary (citable) accession number: P77809

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)