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P77809

- G6PD_AGGAC

UniProt

P77809 - G6PD_AGGAC

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf
Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461NADP By similarity
Binding sitei150 – 1501NADP By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei218 – 2181Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Active sitei242 – 2421Proton acceptor By similarity
Binding sitei342 – 3421Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifieri714 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068108Add
BLAST

Proteomic databases

PRIDEiP77809.

Structurei

3D structure databases

ProteinModelPortaliP77809.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77809-1 [UniParc]FASTAAdd to Basket

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MKAENCCIVI FGASGDLTYR KLIPALYNLY KIDRLGEDFS VLGVARTELN    50
DKSFREKMRQ TLIKNEGAKG ECLEQFCSHL YYQAVNTADK ADYAKLVPRL 100
DELHDTYRTE GNTLYYLSTP PSLYGVIPEC LGEHGLNKED RGWKRLIVEK 150
PFGYDRETAE ALDIQIHRFF EEHQIYRIDH YLGKETVQNL LVLRFSNGWF 200
EPLWNRNFID YIEITGAESI GVEERGGYYD GSGAMRDMFQ NHLLQVLAMV 250
AMEPPVIINA NSMRDEVAKV LHCLRPLTQE DVEHNLVLGQ YVAGEVDGEW 300
VKGYLEEKGV PPYSTTETYM ALRCEIENWR WAGVPFYVRT GKRLPARVTE 350
IVIHFKTTPH PVFSQNAPEN KLIIRIQPDE GISMRFGLKK PGAGFEAKEV 400
SMDFRYADLA GATVMTAYER LLLDAMKGDA TLFARTDAVH AAWKFVQPIL 450
NYKAQGGRLY DYEAGTWGPT AADKLIAKSG RVWRRPSGLM KKKV 494
Length:494
Mass (Da):56,385
Last modified:February 1, 1997 - v1
Checksum:iB0B2A32F349936A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88189 Genomic DNA. Translation: BAA13554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88189 Genomic DNA. Translation: BAA13554.1 .

3D structure databases

ProteinModelPortali P77809.
ModBasei Search...

Proteomic databases

PRIDEi P77809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
    Yoshida Y., Nakano Y., Yamashita Y., Koga T.
    Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43718 / FDC Y4 / Serotype b.

Entry informationi

Entry nameiG6PD_AGGAC
AccessioniPrimary (citable) accession number: P77809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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