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P77809

- G6PD_AGGAC

UniProt

P77809 - G6PD_AGGAC

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461NADPUniRule annotation
Binding sitei150 – 1501NADPUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation
Binding sitei218 – 2181SubstrateUniRule annotation
Binding sitei237 – 2371SubstrateUniRule annotation
Active sitei242 – 2421Proton acceptorUniRule annotation
Binding sitei342 – 3421SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifieri714 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Glucose-6-phosphate 1-dehydrogenasePRO_0000068108Add
BLAST

Proteomic databases

PRIDEiP77809.

Structurei

3D structure databases

ProteinModelPortaliP77809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77809-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAENCCIVI FGASGDLTYR KLIPALYNLY KIDRLGEDFS VLGVARTELN
60 70 80 90 100
DKSFREKMRQ TLIKNEGAKG ECLEQFCSHL YYQAVNTADK ADYAKLVPRL
110 120 130 140 150
DELHDTYRTE GNTLYYLSTP PSLYGVIPEC LGEHGLNKED RGWKRLIVEK
160 170 180 190 200
PFGYDRETAE ALDIQIHRFF EEHQIYRIDH YLGKETVQNL LVLRFSNGWF
210 220 230 240 250
EPLWNRNFID YIEITGAESI GVEERGGYYD GSGAMRDMFQ NHLLQVLAMV
260 270 280 290 300
AMEPPVIINA NSMRDEVAKV LHCLRPLTQE DVEHNLVLGQ YVAGEVDGEW
310 320 330 340 350
VKGYLEEKGV PPYSTTETYM ALRCEIENWR WAGVPFYVRT GKRLPARVTE
360 370 380 390 400
IVIHFKTTPH PVFSQNAPEN KLIIRIQPDE GISMRFGLKK PGAGFEAKEV
410 420 430 440 450
SMDFRYADLA GATVMTAYER LLLDAMKGDA TLFARTDAVH AAWKFVQPIL
460 470 480 490
NYKAQGGRLY DYEAGTWGPT AADKLIAKSG RVWRRPSGLM KKKV
Length:494
Mass (Da):56,385
Last modified:February 1, 1997 - v1
Checksum:iB0B2A32F349936A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88189 Genomic DNA. Translation: BAA13554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88189 Genomic DNA. Translation: BAA13554.1 .

3D structure databases

ProteinModelPortali P77809.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P77809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA."
    Yoshida Y., Nakano Y., Yamashita Y., Koga T.
    Biochem. Biophys. Res. Commun. 230:220-225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43718 / FDC Y4 / Serotype b.

Entry informationi

Entry nameiG6PD_AGGAC
AccessioniPrimary (citable) accession number: P77809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3