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Protein

Probable outer membrane usher protein EcpC

Gene

ecpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fimbrium biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6162-MONOMER.
ECOL316407:JW0285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable outer membrane usher protein EcpC
Gene namesi
Name:ecpC
Synonyms:matD, yagX
Ordered Locus Names:b0291, JW0285
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13563. ecpC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 841812Probable outer membrane usher protein EcpCPRO_0000013788Add
BLAST

Proteomic databases

PaxDbiP77802.
PRIDEiP77802.

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
pkaP765944EBI-561348,EBI-557388

Protein-protein interaction databases

BioGridi4259790. 217 interactions.
DIPiDIP-11250N.
IntActiP77802. 2 interactions.
MINTiMINT-1239865.
STRINGi511145.b0291.

Structurei

3D structure databases

ProteinModelPortaliP77802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpC/MatD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108N3D. Bacteria.
ENOG4110Z57. LUCA.
HOGENOMiHOG000269481.
OMAiYIALDFS.
OrthoDBiEOG62VNGF.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR031917. Pilus_assem_C.
IPR032636. Pilus_assem_dom.
[Graphical view]
PfamiPF15976. CooC_C. 1 hit.
PF16967. TcfC. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLRRFSPGL KAQFAFGMVF LFVQPDASAA DISAQQIGGV IIPQAFSQAL
60 70 80 90 100
QDGMSVPLYI HLAGSQGRQD DQRIGSAFIW LDDGQLRIRK IQLEESEDNA
110 120 130 140 150
SVSEQTRQQL MALANAPFNE ALTIPLTDNA QLDLSLRQLL LQLVVKREAL
160 170 180 190 200
GTVLRSRSED IGQSSVNTLS SNLSYNLGVY NNQLRNGGSN TSSYLSLNNV
210 220 230 240 250
TALREHHVVL DGSLYGIGSG QQDSELYKAM YERDFAGHRF AGGMLDTWNL
260 270 280 290 300
QSLGPMTAIS AGKIYGLSWG NQASSTIFDS SQSATPVIAF LPAAGEVHLT
310 320 330 340 350
RDGRLLSVQN FTMGNHEVDT RGLPYGIYDV EVEVIVNGRV ISKRTQRVNK
360 370 380 390 400
LFSRGRGVGA PLAWQVWGGS FHMDRWSENG KKTRPAKESW LAGASTSGSL
410 420 430 440 450
STLSWAATGY GYDNQAVGET RLTLPLGGAI NVNLQNMLAS DSSWSSIGSI
460 470 480 490 500
SATLPGGFSS LWVNQEKTRI GNQLRRSDAD NRAIGGTLNL NSLWSKLGTF
510 520 530 540 550
SISYNDDRRY NSHYYTADYY QNVYSGTFGS LGLRAGIQRY NNGDSNANTG
560 570 580 590 600
KYIALDLSLP LGNWFSAGMT HQNGYTMANL SARKQFDEGT IRTVGANLSR
610 620 630 640 650
AISGDTGDDK TLSGGAYAQF DARYASGTLN VNSAADGYVN TNLTANGSVG
660 670 680 690 700
WQGKNIAASG RTDGNAGVIF NTGLEDDGQI SAKINGRIFP LNGKRNYLPL
710 720 730 740 750
SPYGRYEVEL QNSKNSLDSY DIVSGRKSRL TLYPGNVAVI EPEVKQMVTV
760 770 780 790 800
SGRIRAEDGT LLANARINNH IGRTRTDENG EFVMDVDKKY PTIDFRYSGN
810 820 830 840
KTCEVALELN QARGAVWVGD VVCSGLSSWA AVTQTGEENE S
Length:841
Mass (Da):91,229
Last modified:February 1, 1997 - v1
Checksum:iD2016BB0ACD726AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18020.1.
U00096 Genomic DNA. Translation: AAC73394.1.
AP009048 Genomic DNA. Translation: BAE76075.1.
PIRiC64755.
RefSeqiNP_414825.1. NC_000913.3.
WP_001131096.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73394; AAC73394; b0291.
BAE76075; BAE76075; BAE76075.
GeneIDi947606.
KEGGiecj:JW0285.
eco:b0291.
PATRICi32115705. VBIEscCol129921_0295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18020.1.
U00096 Genomic DNA. Translation: AAC73394.1.
AP009048 Genomic DNA. Translation: BAE76075.1.
PIRiC64755.
RefSeqiNP_414825.1. NC_000913.3.
WP_001131096.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259790. 217 interactions.
DIPiDIP-11250N.
IntActiP77802. 2 interactions.
MINTiMINT-1239865.
STRINGi511145.b0291.

Proteomic databases

PaxDbiP77802.
PRIDEiP77802.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73394; AAC73394; b0291.
BAE76075; BAE76075; BAE76075.
GeneIDi947606.
KEGGiecj:JW0285.
eco:b0291.
PATRICi32115705. VBIEscCol129921_0295.

Organism-specific databases

EchoBASEiEB3333.
EcoGeneiEG13563. ecpC.

Phylogenomic databases

eggNOGiENOG4108N3D. Bacteria.
ENOG4110Z57. LUCA.
HOGENOMiHOG000269481.
OMAiYIALDFS.
OrthoDBiEOG62VNGF.

Enzyme and pathway databases

BioCyciEcoCyc:G6162-MONOMER.
ECOL316407:JW0285-MONOMER.

Miscellaneous databases

PROiP77802.

Family and domain databases

Gene3Di2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR031917. Pilus_assem_C.
IPR032636. Pilus_assem_dom.
[Graphical view]
PfamiPF15976. CooC_C. 1 hit.
PF16967. TcfC. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Mat fimbriae promote biofilm formation by meningitis-associated Escherichia coli."
    Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K., Dobrindt U., Westerlund-Wikstrom B.
    Microbiology 156:2408-2417(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: EXPRESSION.
    Strain: K12.

Entry informationi

Entry nameiECPC_ECOLI
AccessioniPrimary (citable) accession number: P77802
Secondary accession number(s): Q2MCD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.