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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).By similarity1 Publication

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188ZincBy similarity1
Metal bindingi197ZincBy similarity1
Metal bindingi200ZincBy similarity1
Metal bindingi203ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 18ATPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processQueuosine biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G6245-MONOMER
MetaCyc:G6245-MONOMER
UniPathwayiUPA00391

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase
PreQ(0) synthase
Queuosine biosynthesis protein QueC
Gene namesi
Name:queC
Synonyms:ybaX
Ordered Locus Names:b0444, JW0434
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13252 queC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686311 – 2317-cyano-7-deazaguanine synthaseAdd BLAST231

Proteomic databases

EPDiP77756
PaxDbiP77756
PRIDEiP77756

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tufAP0CE473EBI-560024,EBI-301077

Protein-protein interaction databases

BioGridi4262187, 62 interactors
DIPiDIP-11311N
IntActiP77756, 14 interactors
STRINGi316385.ECDH10B_0400

Structurei

3D structure databases

ProteinModelPortaliP77756
SMRiP77756
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.Curated

Phylogenomic databases

eggNOGiENOG4105FD2 Bacteria
COG0603 LUCA
HOGENOMiHOG000110563
InParanoidiP77756
KOiK06920
OMAiVWVPARN
PhylomeDBiP77756

Family and domain databases

CDDicd01995 ExsB, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_01633 QueC, 1 hit
InterProiView protein in InterPro
IPR018317 QueC
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR42914 PTHR42914, 1 hit
PfamiView protein in Pfam
PF06508 QueC, 1 hit
PIRSFiPIRSF006293 ExsB, 1 hit
TIGRFAMsiTIGR00364 TIGR00364, 1 hit

Sequencei

Sequence statusi: Complete.

P77756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAVVVFSG GQDSTTCLVQ ALQQYDEVHC VTFDYGQRHR AEIDVARELA
60 70 80 90 100
LKLGARAHKV LDVTLLNELA VSSLTRDSIP VPDYEPEADG IPNTFVPGRN
110 120 130 140 150
ILFLTLAAIY AYQVKAEAVI TGVCETDFSG YPDCRDEFVK ALNHAVSLGM
160 170 180 190 200
AKDIRFETPL MWIDKAETWA LADYYGKLDL VRNETLTCYN GFKGDGCGHC
210 220 230
AACNLRANGL NHYLADKPTV MAAMKQKTGL R
Length:231
Mass (Da):25,514
Last modified:February 1, 1997 - v1
Checksum:i69E20ED03E6E3E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82943 Genomic DNA Translation: BAA11648.1
U82664 Genomic DNA Translation: AAB40200.1
U00096 Genomic DNA Translation: AAC73547.1
AP009048 Genomic DNA Translation: BAE76224.1
PIRiD64774
RefSeqiNP_414978.1, NC_000913.3
WP_000817220.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73547; AAC73547; b0444
BAE76224; BAE76224; BAE76224
GeneIDi947034
KEGGiecj:JW0434
eco:b0444
PATRICifig|1411691.4.peg.1832

Similar proteinsi

Entry informationi

Entry nameiQUEC_ECOLI
AccessioniPrimary (citable) accession number: P77756
Secondary accession number(s): Q2MBY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health