Reviewed, UniProtKB/Swiss-Prot P77756 (QUEC_ECOLI)

Names and origin

Protein names

Recommended name:
    Queuosine biosynthesis protein queC

Gene names

Name:	queC
Synonyms:	ybaX
Ordered Locus Names:	b0444, JW0434

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0). Ref.5
Pathway	Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. HAMAP MF_01633
Sequence similarities	Belongs to the queC family.

Ontologies

Keywords
Biological process	Queuosine biosynthesis
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: InterPro queuosine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro argininosuccinate synthase activity Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
tufA	P0A6N1	1	EBI-560024,EBI-301077

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Queuosine biosynthesis protein queC HAMAP MF_01633		PRO_0000168631

Sequences

	Sequence		Length	Mass (Da)
	P77756-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 69E20ED03E6E3E34	FASTA	231	25,514
	10 20 30 40 50 60 MKRAVVVFSG GQDSTTCLVQ ALQQYDEVHC VTFDYGQRHR AEIDVARELA LKLGARAHKV 70 80 90 100 110 120 LDVTLLNELA VSSLTRDSIP VPDYEPEADG IPNTFVPGRN ILFLTLAAIY AYQVKAEAVI 130 140 150 160 170 180 TGVCETDFSG YPDCRDEFVK ALNHAVSLGM AKDIRFETPL MWIDKAETWA LADYYGKLDL 190 200 210 220 230 VRNETLTCYN GFKGDGCGHC AACNLRANGL NHYLADKPTV MAAMKQKTGL R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of the E. coli chromosome around the 10.0 min region." Hatada E., Ohmori H., Qiao Y., Tsuji M., Fukuda R. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli." Gaur R., Varshney U. J. Bacteriol. 187:6893-6901(2005) [PubMed: 16199558] [Abstract] Cited for: FUNCTION. Strain: B105.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D82943 Genomic DNA. Translation: BAA11648.1. U82664 Genomic DNA. Translation: AAB40200.1. U00096 Genomic DNA. Translation: AAC73547.1. AP009048 Genomic DNA. Translation: BAE76224.1.
PIR	D64774.
RefSeq	AP_001094.1. NP_414978.1.
3D structure databases
SMR	P77756. Positions 1-230.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:11311N.
IntAct	P77756. 14 interactions.
STRING	P77756.
Genome annotation databases
GeneID	947034.
GenomeReviews	Gene locus JW0434 in contig AP009048_GR. Gene locus b0444 in contig U00096_GR.
KEGG	ecj:JW0434. eco:b0444.
Organism-specific databases
EchoBASE	EB3041.
EcoGene	EG13252. queC.
CMR	Search...
Phylogenomic databases
HOGENOM	P77756.
OMA	CETDYSG.
Enzyme and pathway databases
BioCyc	EcoCyc:G6245-MON.
Gene expression databases
Genevestigator	P77756.
Family and domain databases
HAMAP	MF_01633. [Tree]
InterPro	IPR001518. Arginosuc_synth. IPR004479. ExsB/QueC. IPR018317. Queuosine_synth-like. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11587. Arginosuc_synth. 1 hit.
Pfam	PF06508. ExsB. 1 hit. [Graphical view]
PIRSF	PIRSF006293. ExsB. 1 hit.
TIGRFAMs	TIGR00364. ExsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

QUEC_ECOLI

Accession

Primary (citable) accession number: P77756
Secondary accession number(s): Q2MBY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)