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Protein

Uncharacterized HTH-type transcriptional regulator YbdO

Gene

ybdO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

The protein is quite variable across different genetic subgroups, probably due to its binding and repression by H-NS (PubMed:26789284).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi27 – 46H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6332-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized HTH-type transcriptional regulator YbdO
Gene namesi
Name:ybdO
Ordered Locus Names:b0603, JW0596
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13534 ybdO

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057781 – 300Uncharacterized HTH-type transcriptional regulator YbdOAdd BLAST300

Proteomic databases

PaxDbiP77746
PRIDEiP77746

Expressioni

Inductioni

Induced by LeuO, a monocistronic operon (PubMed:19429622). Maximally induced in early stationary phase, repressed by H-NS via 2 binding sites in the upstream and coding region; H-NS may bind both regions to form a bridge which then prevents transcription (PubMed:26789284).2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4260901, 8 interactors
IntActiP77746, 5 interactors
STRINGi316385.ECDH10B_0672

Structurei

3D structure databases

ProteinModelPortaliP77746
SMRiP77746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 67HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105DQS Bacteria
ENOG410XQ6Z LUCA
HOGENOMiHOG000117868
OMAiVHPLFTE
PhylomeDBiP77746

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P77746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLYDLKKF DLNLLVIFEC IYQHLSISKA AESLYITPSA VSQSLQRLRA
60 70 80 90 100
QFNDPLFIRS GKGIAPTTTG LNLHHHLEKN LRGLEQTINI VNKSELKKNF
110 120 130 140 150
IIYGPQLISC SNNSMLIRCL RQDSSVEIEC HDILMSAENA EELLVHRKAD
160 170 180 190 200
LVITQMPVIS RSVICMPLHT IRNTLICSNR HPRITDNSTY EQIMAEEFTQ
210 220 230 240 250
LISKSAGVDD IQMEIDERFM NRKISFRGSS LLTIINSIAV TDLLGIVPYE
260 270 280 290 300
LYNSYRDFLN LKEIKLEHPL PSIKLYISYN KSSLNNLVFS RFIDRLNESF
Length:300
Mass (Da):34,397
Last modified:February 1, 1997 - v1
Checksum:i1A5ECC6F28123D4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40804.1
U00096 Genomic DNA Translation: AAC73704.1
AP009048 Genomic DNA Translation: BAA35233.1
PIRiA64794
RefSeqiNP_415136.1, NC_000913.3
WP_000002474.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73704; AAC73704; b0603
BAA35233; BAA35233; BAA35233
GeneIDi945216
KEGGiecj:JW0596
eco:b0603
PATRICifig|1411691.4.peg.1665

Similar proteinsi

Entry informationi

Entry nameiYBDO_ECOLI
AccessioniPrimary (citable) accession number: P77746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health