P77746 (YBDO_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized HTH-type transcriptional regulator YbdO

Gene names

Name:	ybdO
Ordered Locus Names:	b0603, JW0596

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Induction	Induced by LeuO, a monocistronic operon. Ref.5
Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Uncharacterized HTH-type transcriptional regulator YbdO		PRO_0000105778
Regions
	Domain	10 – 67	58	HTH lysR-type
	DNA binding	27 – 46	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P77746 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 1A5ECC6F28123D4F	FASTA	300	34,397
	10 20 30 40 50 60 MANLYDLKKF DLNLLVIFEC IYQHLSISKA AESLYITPSA VSQSLQRLRA QFNDPLFIRS 70 80 90 100 110 120 GKGIAPTTTG LNLHHHLEKN LRGLEQTINI VNKSELKKNF IIYGPQLISC SNNSMLIRCL 130 140 150 160 170 180 RQDSSVEIEC HDILMSAENA EELLVHRKAD LVITQMPVIS RSVICMPLHT IRNTLICSNR 190 200 210 220 230 240 HPRITDNSTY EQIMAEEFTQ LISKSAGVDD IQMEIDERFM NRKISFRGSS LLTIINSIAV 250 260 270 280 290 300 TDLLGIVPYE LYNSYRDFLN LKEIKLEHPL PSIKLYISYN KSSLNNLVFS RFIDRLNESF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux." Shimada T., Yamamoto K., Ishihama A. J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract] Cited for: OPERON STRUCTURE, INDUCTION. Strain: K12 / BW25113.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82598 Genomic DNA. Translation: AAB40804.1. U00096 Genomic DNA. Translation: AAC73704.1. AP009048 Genomic DNA. Translation: BAA35233.1.
PIR	A64794.
RefSeq	NP_415136.1. NC_000913.2. YP_488893.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P77746.
SMR	P77746. Positions 17-67.
ModBase	Search...
Protein-protein interaction databases
IntAct	P77746. 4 interactions.
STRING	511145.b0603.
Proteomic databases
PRIDE	P77746.
Protocols and materials databases
DNASU	945216.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73704; AAC73704; b0603. BAA35233; BAA35233; BAA35233.
GeneID	12931907. 945216.
KEGG	ecj:Y75_p0593. eco:b0603.
PATRIC	32116384. VBIEscCol129921_0632.
Organism-specific databases
EchoBASE	EB3305.
EcoGene	EG13534. ybdO.
Phylogenomic databases
eggNOG	COG0583.
HOGENOM	HOG000117868.
OMA	ITPTTVG.
ProtClustDB	CLSK879708.
Enzyme and pathway databases
BioCyc	EcoCyc:G6332-MONOMER. ECOL316407:JW0596-MONOMER.
Gene expression databases
Genevestigator	P77746.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005119. LysR_subst-bd. IPR000847. Tscrpt_reg_HTH_LysR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PRINTS	PR00039. HTHLYSR.
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YBDO_ECOLI

Accession

Primary (citable) accession number: P77746

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program