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Protein

Propionate catabolism operon regulatory protein

Gene

prpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of the propionate catabolism operon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi318 – 327ATPPROSITE-ProRule annotation10
DNA bindingi508 – 527H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6195-MONOMER.
ECOL316407:JW0322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionate catabolism operon regulatory protein
Gene namesi
Name:prpR
Synonyms:yahP
Ordered Locus Names:b0330, JW0322
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13600. prpR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000813241 – 528Propionate catabolism operon regulatory proteinAdd BLAST528

Proteomic databases

PaxDbiP77743.
PRIDEiP77743.

Interactioni

Protein-protein interaction databases

BioGridi4259807. 13 interactors.
DIPiDIP-10582N.
IntActiP77743. 1 interactor.
STRINGi511145.b0330.

Structurei

Secondary structure

1528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 17Combined sources5
Helixi20 – 30Combined sources11
Turni31 – 36Combined sources6
Beta strandi38 – 42Combined sources5
Helixi46 – 56Combined sources11
Turni57 – 59Combined sources3
Beta strandi63 – 68Combined sources6
Helixi69 – 76Combined sources8
Beta strandi83 – 86Combined sources4
Helixi90 – 99Combined sources10
Beta strandi107 – 114Combined sources8
Helixi117 – 126Combined sources10
Beta strandi130 – 137Combined sources8
Helixi138 – 150Combined sources13
Beta strandi155 – 159Combined sources5
Helixi160 – 168Combined sources9
Beta strandi171 – 177Combined sources7
Helixi179 – 195Combined sources17
Helixi199 – 204Combined sources6
Helixi212 – 215Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PJUX-ray2.10A/B/C/D2-215[»]
ProteinModelPortaliP77743.
SMRiP77743.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77743.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 461Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST244

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JU7. Bacteria.
COG1221. LUCA.
HOGENOMiHOG000058487.
InParanoidiP77743.
KOiK02688.
OMAiIMLYARS.
PhylomeDBiP77743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR012704. Sig_transdc_resp-reg_PrpR.
IPR010524. Sig_transdc_resp-reg_PrpR_N.
IPR002078. Sigma_54_int.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF06506. PrpR_N. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02329. propionate_PrpR. 1 hit.
PROSITEiPS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPPRLNDD KPVIWTVSVT RLFELFRDIS LEFDHLANIT PIQLGFEKAV
60 70 80 90 100
TYIRKKLANE RCDAIIAAGS NGAYLKSRLS VPVILIKPSG YDVLQALAKA
110 120 130 140 150
GKLTSSIGVV TYQETIPALV AFQKTFNLRL DQRSYITEED ARGQINELKA
160 170 180 190 200
NGTEAVVGAG LITDLAEEAG MTGIFIYSAA TVRQAFSDAL DMTRMSLRHN
210 220 230 240 250
THDATRNALR TRYVLGDMLG QSPQMEQVRQ TILLYARSSA AVLIEGETGT
260 270 280 290 300
GKELAAQAIH REYFARHDAR QGKKSHPFVA VNCGAIAESL LEAELFGYEE
310 320 330 340 350
GAFTGSRRGG RAGLFEIAHG GTLFLDEIGE MPLPLQTRLL RVLEEKEVTR
360 370 380 390 400
VGGHQPVPVD VRVISATHCN LEEDMQQGRF RRDLFYRLSI LRLQLPPLRE
410 420 430 440 450
RVADILPLAE SFLKVSLAAL SAPFSAALRQ GLQASETVLL HYDWPGNIRE
460 470 480 490 500
LRNMMERLAL FLSVEPTPDL TPQFMQLLLP ELARESAKTP APRLLTPQQA
510 520
LEKFNGDKTA AANYLGISRT TFWRRLKS
Length:528
Mass (Da):58,649
Last modified:February 1, 1997 - v1
Checksum:i8EAFD1F55D96E8FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18054.1.
U00096 Genomic DNA. Translation: AAC73433.1.
AP009048 Genomic DNA. Translation: BAE76113.1.
PIRiB64760.
RefSeqiNP_414864.1. NC_000913.3.
WP_000941041.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73433; AAC73433; b0330.
BAE76113; BAE76113; BAE76113.
GeneIDi944987.
KEGGiecj:JW0322.
eco:b0330.
PATRICi32115791. VBIEscCol129921_0337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18054.1.
U00096 Genomic DNA. Translation: AAC73433.1.
AP009048 Genomic DNA. Translation: BAE76113.1.
PIRiB64760.
RefSeqiNP_414864.1. NC_000913.3.
WP_000941041.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PJUX-ray2.10A/B/C/D2-215[»]
ProteinModelPortaliP77743.
SMRiP77743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259807. 13 interactors.
DIPiDIP-10582N.
IntActiP77743. 1 interactor.
STRINGi511145.b0330.

Proteomic databases

PaxDbiP77743.
PRIDEiP77743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73433; AAC73433; b0330.
BAE76113; BAE76113; BAE76113.
GeneIDi944987.
KEGGiecj:JW0322.
eco:b0330.
PATRICi32115791. VBIEscCol129921_0337.

Organism-specific databases

EchoBASEiEB3369.
EcoGeneiEG13600. prpR.

Phylogenomic databases

eggNOGiENOG4108JU7. Bacteria.
COG1221. LUCA.
HOGENOMiHOG000058487.
InParanoidiP77743.
KOiK02688.
OMAiIMLYARS.
PhylomeDBiP77743.

Enzyme and pathway databases

BioCyciEcoCyc:G6195-MONOMER.
ECOL316407:JW0322-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP77743.
PROiP77743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR012704. Sig_transdc_resp-reg_PrpR.
IPR010524. Sig_transdc_resp-reg_PrpR_N.
IPR002078. Sigma_54_int.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF06506. PrpR_N. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02329. propionate_PrpR. 1 hit.
PROSITEiPS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRPR_ECOLI
AccessioniPrimary (citable) accession number: P77743
Secondary accession number(s): Q2MC93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.