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Protein

Propionate catabolism operon regulatory protein

Gene

prpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of the propionate catabolism operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi318 – 32710ATPPROSITE-ProRule annotation
DNA bindingi508 – 52720H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6195-MONOMER.
ECOL316407:JW0322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionate catabolism operon regulatory protein
Gene namesi
Name:prpR
Synonyms:yahP
Ordered Locus Names:b0330, JW0322
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13600. prpR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Propionate catabolism operon regulatory proteinPRO_0000081324Add
BLAST

Proteomic databases

PaxDbiP77743.
PRIDEiP77743.

Interactioni

Protein-protein interaction databases

BioGridi4259807. 13 interactions.
DIPiDIP-10582N.
IntActiP77743. 1 interaction.
STRINGi511145.b0330.

Structurei

Secondary structure

1
528
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 175Combined sources
Helixi20 – 3011Combined sources
Turni31 – 366Combined sources
Beta strandi38 – 425Combined sources
Helixi46 – 5611Combined sources
Turni57 – 593Combined sources
Beta strandi63 – 686Combined sources
Helixi69 – 768Combined sources
Beta strandi83 – 864Combined sources
Helixi90 – 9910Combined sources
Beta strandi107 – 1148Combined sources
Helixi117 – 12610Combined sources
Beta strandi130 – 1378Combined sources
Helixi138 – 15013Combined sources
Beta strandi155 – 1595Combined sources
Helixi160 – 1689Combined sources
Beta strandi171 – 1777Combined sources
Helixi179 – 19517Combined sources
Helixi199 – 2046Combined sources
Helixi212 – 2154Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PJUX-ray2.10A/B/C/D2-215[»]
ProteinModelPortaliP77743.
SMRiP77743. Positions 11-526.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77743.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 461244Sigma-54 factor interactionPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JU7. Bacteria.
COG1221. LUCA.
HOGENOMiHOG000058487.
InParanoidiP77743.
KOiK02688.
OMAiIMLYARS.
PhylomeDBiP77743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR012704. Sig_transdc_resp-reg_PrpR.
IPR010524. Sig_transdc_resp-reg_PrpR_N.
IPR002078. Sigma_54_int.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF06506. PrpR_N. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02329. propionate_PrpR. 1 hit.
PROSITEiPS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPPRLNDD KPVIWTVSVT RLFELFRDIS LEFDHLANIT PIQLGFEKAV
60 70 80 90 100
TYIRKKLANE RCDAIIAAGS NGAYLKSRLS VPVILIKPSG YDVLQALAKA
110 120 130 140 150
GKLTSSIGVV TYQETIPALV AFQKTFNLRL DQRSYITEED ARGQINELKA
160 170 180 190 200
NGTEAVVGAG LITDLAEEAG MTGIFIYSAA TVRQAFSDAL DMTRMSLRHN
210 220 230 240 250
THDATRNALR TRYVLGDMLG QSPQMEQVRQ TILLYARSSA AVLIEGETGT
260 270 280 290 300
GKELAAQAIH REYFARHDAR QGKKSHPFVA VNCGAIAESL LEAELFGYEE
310 320 330 340 350
GAFTGSRRGG RAGLFEIAHG GTLFLDEIGE MPLPLQTRLL RVLEEKEVTR
360 370 380 390 400
VGGHQPVPVD VRVISATHCN LEEDMQQGRF RRDLFYRLSI LRLQLPPLRE
410 420 430 440 450
RVADILPLAE SFLKVSLAAL SAPFSAALRQ GLQASETVLL HYDWPGNIRE
460 470 480 490 500
LRNMMERLAL FLSVEPTPDL TPQFMQLLLP ELARESAKTP APRLLTPQQA
510 520
LEKFNGDKTA AANYLGISRT TFWRRLKS
Length:528
Mass (Da):58,649
Last modified:February 1, 1997 - v1
Checksum:i8EAFD1F55D96E8FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18054.1.
U00096 Genomic DNA. Translation: AAC73433.1.
AP009048 Genomic DNA. Translation: BAE76113.1.
PIRiB64760.
RefSeqiNP_414864.1. NC_000913.3.
WP_000941041.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73433; AAC73433; b0330.
BAE76113; BAE76113; BAE76113.
GeneIDi944987.
KEGGiecj:JW0322.
eco:b0330.
PATRICi32115791. VBIEscCol129921_0337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18054.1.
U00096 Genomic DNA. Translation: AAC73433.1.
AP009048 Genomic DNA. Translation: BAE76113.1.
PIRiB64760.
RefSeqiNP_414864.1. NC_000913.3.
WP_000941041.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PJUX-ray2.10A/B/C/D2-215[»]
ProteinModelPortaliP77743.
SMRiP77743. Positions 11-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259807. 13 interactions.
DIPiDIP-10582N.
IntActiP77743. 1 interaction.
STRINGi511145.b0330.

Proteomic databases

PaxDbiP77743.
PRIDEiP77743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73433; AAC73433; b0330.
BAE76113; BAE76113; BAE76113.
GeneIDi944987.
KEGGiecj:JW0322.
eco:b0330.
PATRICi32115791. VBIEscCol129921_0337.

Organism-specific databases

EchoBASEiEB3369.
EcoGeneiEG13600. prpR.

Phylogenomic databases

eggNOGiENOG4108JU7. Bacteria.
COG1221. LUCA.
HOGENOMiHOG000058487.
InParanoidiP77743.
KOiK02688.
OMAiIMLYARS.
PhylomeDBiP77743.

Enzyme and pathway databases

BioCyciEcoCyc:G6195-MONOMER.
ECOL316407:JW0322-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP77743.
PROiP77743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR012704. Sig_transdc_resp-reg_PrpR.
IPR010524. Sig_transdc_resp-reg_PrpR_N.
IPR002078. Sigma_54_int.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF06506. PrpR_N. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02329. propionate_PrpR. 1 hit.
PROSITEiPS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRPR_ECOLI
AccessioniPrimary (citable) accession number: P77743
Secondary accession number(s): Q2MC93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.