Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable formate transporter 2

Gene

focB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the bidirectional transport of formate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:FOCB-MONOMER.
ECOL316407:JW2477-MONOMER.

Protein family/group databases

TCDBi1.A.16.1.2. the formate-nitrite transporter (fnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable formate transporter 2
Alternative name(s):
Formate channel 2
Gene namesi
Name:focB
Ordered Locus Names:b2492, JW2477
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14220. focB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Topological domaini57 – 6812PeriplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 11223CytoplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 16330PeriplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 1906CytoplasmicSequence analysis
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 24837PeriplasmicSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 28213CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Probable formate transporter 2PRO_0000094721Add
BLAST

Proteomic databases

PaxDbiP77733.

Interactioni

Protein-protein interaction databases

BioGridi4261432. 6 interactions.
DIPiDIP-9671N.
IntActiP77733. 1 interaction.
MINTiMINT-1231949.
STRINGi511145.b2492.

Structurei

3D structure databases

ProteinModelPortaliP77733.
SMRiP77733. Positions 32-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105TMB. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271393.
InParanoidiP77733.
KOiK03459.
OMAiNTMYFTT.
OrthoDBiEOG6QRW6X.
PhylomeDBiP77733.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNKLSFDLQ LSARKAAIAE RIAAHKIARS KVSVFLMAMS AGVFMAIGFT
60 70 80 90 100
FYLSVIADAP SSQALTHLVG GLCFTLGFIL LAVCGTSLFT SSVMTVMAKS
110 120 130 140 150
RGVISWRTWL INALLVACGN LAGIACFSLL IWFSGLVMSE NAMWGVAVLH
160 170 180 190 200
CAEGKMHHTF TESVSLGIMC NLMVCLALWM SYCGRSLCDK IVAMILPITL
210 220 230 240 250
FVASGFEHCI ANLFVIPFAI AIRHFAPPPF WQLAHSSADN FPALTVSHFI
260 270 280
TANLLPVMLG NIIGGAVLVS MCYRAIYLRQ EP
Length:282
Mass (Da):30,565
Last modified:February 1, 1997 - v1
Checksum:i403929CDF55EDE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88574.1.
U00096 Genomic DNA. Translation: AAC75545.1.
AP009048 Genomic DNA. Translation: BAA16381.1.
PIRiC65025.
RefSeqiNP_416987.1. NC_000913.3.
WP_001244734.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75545; AAC75545; b2492.
BAA16381; BAA16381; BAA16381.
GeneIDi949032.
KEGGiecj:JW2477.
eco:b2492.
PATRICi32120371. VBIEscCol129921_2588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88574.1.
U00096 Genomic DNA. Translation: AAC75545.1.
AP009048 Genomic DNA. Translation: BAA16381.1.
PIRiC65025.
RefSeqiNP_416987.1. NC_000913.3.
WP_001244734.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77733.
SMRiP77733. Positions 32-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261432. 6 interactions.
DIPiDIP-9671N.
IntActiP77733. 1 interaction.
MINTiMINT-1231949.
STRINGi511145.b2492.

Protein family/group databases

TCDBi1.A.16.1.2. the formate-nitrite transporter (fnt) family.

Proteomic databases

PaxDbiP77733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75545; AAC75545; b2492.
BAA16381; BAA16381; BAA16381.
GeneIDi949032.
KEGGiecj:JW2477.
eco:b2492.
PATRICi32120371. VBIEscCol129921_2588.

Organism-specific databases

EchoBASEiEB3972.
EcoGeneiEG14220. focB.

Phylogenomic databases

eggNOGiENOG4105TMB. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271393.
InParanoidiP77733.
KOiK03459.
OMAiNTMYFTT.
OrthoDBiEOG6QRW6X.
PhylomeDBiP77733.

Enzyme and pathway databases

BioCyciEcoCyc:FOCB-MONOMER.
ECOL316407:JW2477-MONOMER.

Miscellaneous databases

PROiP77733.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Andrews S.C., McClay J., Ambler A., Quail M., Berks B.C., Guest J.R.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiFOCB_ECOLI
AccessioniPrimary (citable) accession number: P77733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.