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Protein

Probable formate transporter 2

Gene

focB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the bidirectional transport of formate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:FOCB-MONOMER.
ECOL316407:JW2477-MONOMER.

Protein family/group databases

TCDBi1.A.16.1.2. the formate-nitrite transporter (fnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable formate transporter 2
Alternative name(s):
Formate channel 2
Gene namesi
Name:focB
Ordered Locus Names:b2492, JW2477
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14220. focB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 68PeriplasmicSequence analysisAdd BLAST12
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 112CytoplasmicSequence analysisAdd BLAST23
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 163PeriplasmicSequence analysisAdd BLAST30
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 190CytoplasmicSequence analysis6
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 248PeriplasmicSequence analysisAdd BLAST37
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 282CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947211 – 282Probable formate transporter 2Add BLAST282

Proteomic databases

PaxDbiP77733.
PRIDEiP77733.

Interactioni

Protein-protein interaction databases

BioGridi4261432. 6 interactors.
DIPiDIP-9671N.
IntActiP77733. 1 interactor.
MINTiMINT-1231949.
STRINGi511145.b2492.

Structurei

3D structure databases

ProteinModelPortaliP77733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105TMB. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271393.
InParanoidiP77733.
KOiK03459.
OMAiKILAIWF.
PhylomeDBiP77733.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNKLSFDLQ LSARKAAIAE RIAAHKIARS KVSVFLMAMS AGVFMAIGFT
60 70 80 90 100
FYLSVIADAP SSQALTHLVG GLCFTLGFIL LAVCGTSLFT SSVMTVMAKS
110 120 130 140 150
RGVISWRTWL INALLVACGN LAGIACFSLL IWFSGLVMSE NAMWGVAVLH
160 170 180 190 200
CAEGKMHHTF TESVSLGIMC NLMVCLALWM SYCGRSLCDK IVAMILPITL
210 220 230 240 250
FVASGFEHCI ANLFVIPFAI AIRHFAPPPF WQLAHSSADN FPALTVSHFI
260 270 280
TANLLPVMLG NIIGGAVLVS MCYRAIYLRQ EP
Length:282
Mass (Da):30,565
Last modified:February 1, 1997 - v1
Checksum:i403929CDF55EDE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88574.1.
U00096 Genomic DNA. Translation: AAC75545.1.
AP009048 Genomic DNA. Translation: BAA16381.1.
PIRiC65025.
RefSeqiNP_416987.1. NC_000913.3.
WP_001244734.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75545; AAC75545; b2492.
BAA16381; BAA16381; BAA16381.
GeneIDi949032.
KEGGiecj:JW2477.
eco:b2492.
PATRICi32120371. VBIEscCol129921_2588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88574.1.
U00096 Genomic DNA. Translation: AAC75545.1.
AP009048 Genomic DNA. Translation: BAA16381.1.
PIRiC65025.
RefSeqiNP_416987.1. NC_000913.3.
WP_001244734.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261432. 6 interactors.
DIPiDIP-9671N.
IntActiP77733. 1 interactor.
MINTiMINT-1231949.
STRINGi511145.b2492.

Protein family/group databases

TCDBi1.A.16.1.2. the formate-nitrite transporter (fnt) family.

Proteomic databases

PaxDbiP77733.
PRIDEiP77733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75545; AAC75545; b2492.
BAA16381; BAA16381; BAA16381.
GeneIDi949032.
KEGGiecj:JW2477.
eco:b2492.
PATRICi32120371. VBIEscCol129921_2588.

Organism-specific databases

EchoBASEiEB3972.
EcoGeneiEG14220. focB.

Phylogenomic databases

eggNOGiENOG4105TMB. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271393.
InParanoidiP77733.
KOiK03459.
OMAiKILAIWF.
PhylomeDBiP77733.

Enzyme and pathway databases

BioCyciEcoCyc:FOCB-MONOMER.
ECOL316407:JW2477-MONOMER.

Miscellaneous databases

PROiP77733.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOCB_ECOLI
AccessioniPrimary (citable) accession number: P77733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.