Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ureidoglycolate lyase

Gene

allA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.UniRule annotation2 Publications

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.UniRule annotation1 Publication

Cofactori

Ni2+UniRule annotation1 Publication

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processPurine metabolism

Enzyme and pathway databases

BioCyciEcoCyc:G6275-MONOMER
MetaCyc:G6275-MONOMER
UniPathwayiUPA00395

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyaseUniRule annotation (EC:4.3.2.3UniRule annotation)
Alternative name(s):
UreidoglycolataseUniRule annotation
Ureidoglycolate hydrolase
Gene namesi
Name:allAUniRule annotation
Synonyms:glxA2, ybbT
Ordered Locus Names:b0505, JW0493
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13615 allA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205471 – 160Ureidoglycolate lyaseAdd BLAST160

Proteomic databases

PaxDbiP77731
PRIDEiP77731

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions and by glyoxylate under aerobic conditions.

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi4259861, 14 interactors
IntActiP77731, 4 interactors
STRINGi316385.ECDH10B_0461

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi10 – 13Combined sources4
Turni14 – 16Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi36 – 44Combined sources9
Beta strandi46 – 48Combined sources3
Beta strandi52 – 59Combined sources8
Beta strandi67 – 73Combined sources7
Beta strandi79 – 85Combined sources7
Beta strandi90 – 95Combined sources6
Beta strandi97 – 99Combined sources3
Beta strandi101 – 109Combined sources9
Beta strandi115 – 118Combined sources4
Beta strandi129 – 132Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi148 – 158Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSQX-ray1.60A/B1-160[»]
ProteinModelPortaliP77731
SMRiP77731
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77731

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z2U Bacteria
COG3194 LUCA
HOGENOMiHOG000256169
InParanoidiP77731
KOiK01483
OMAiNCDIFQF
PhylomeDBiP77731

Family and domain databases

Gene3Di2.60.120.480, 1 hit
HAMAPiMF_00616 Ureidogly_lyase, 1 hit
InterProiView protein in InterPro
IPR011051 RmlC_Cupin_sf
IPR007247 Ureidogly_lyase
IPR023525 Ureidogly_lyase_bac
IPR024060 Ureidoglycolate_lyase_dom_sf
PANTHERiPTHR21221 PTHR21221, 1 hit
PfamiView protein in Pfam
PF04115 Ureidogly_lyase, 1 hit
PIRSFiPIRSF017306 Ureidogly_hydro, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

P77731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD
60 70 80 90 100
CTLISINRAQ PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP
110 120 130 140 150
DLSTLRAFIT NGEQGVNYHR NVWHHPLFAW QRVTDFLTID RGGSDNCDVE
160
SIPEQELCFA
Length:160
Mass (Da):18,170
Last modified:February 1, 1997 - v1
Checksum:i88FDA2A7D48D6E97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89024 Genomic DNA Translation: AAB93846.1
U82664 Genomic DNA Translation: AAB40258.1
U00096 Genomic DNA Translation: AAC73607.1
AP009048 Genomic DNA Translation: BAE76283.1
PIRiH64781
RefSeqiNP_415038.1, NC_000913.3
WP_000776377.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73607; AAC73607; b0505
BAE76283; BAE76283; BAE76283
GeneIDi945141
KEGGiecj:JW0493
eco:b0505
PATRICifig|1411691.4.peg.1772

Similar proteinsi

Entry informationi

Entry nameiALLA_ECOLI
AccessioniPrimary (citable) accession number: P77731
Secondary accession number(s): Q2MBS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health