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Protein

Ureidoglycolate lyase

Gene

allA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.UniRule annotation2 Publications

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.UniRule annotation1 Publication

Cofactori

Ni2+UniRule annotation1 Publication

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BioCyciEcoCyc:G6275-MONOMER.
ECOL316407:JW0493-MONOMER.
MetaCyc:G6275-MONOMER.
UniPathwayiUPA00395.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyaseUniRule annotation (EC:4.3.2.3UniRule annotation)
Alternative name(s):
UreidoglycolataseUniRule annotation
Ureidoglycolate hydrolase
Gene namesi
Name:allAUniRule annotation
Synonyms:glxA2, ybbT
Ordered Locus Names:b0505, JW0493
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13615. allA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Ureidoglycolate lyasePRO_0000120547Add
BLAST

Proteomic databases

PaxDbiP77731.
PRIDEiP77731.

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions and by glyoxylate under aerobic conditions.

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi4259861. 14 interactions.
IntActiP77731. 4 interactions.
STRINGi511145.b0505.

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Helixi10 – 134Combined sources
Turni14 – 163Combined sources
Beta strandi17 – 204Combined sources
Beta strandi36 – 449Combined sources
Beta strandi46 – 483Combined sources
Beta strandi52 – 598Combined sources
Beta strandi67 – 737Combined sources
Beta strandi79 – 857Combined sources
Beta strandi90 – 956Combined sources
Beta strandi97 – 993Combined sources
Beta strandi101 – 1099Combined sources
Beta strandi115 – 1184Combined sources
Beta strandi129 – 1324Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi148 – 15811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XSQX-ray1.60A/B1-160[»]
ProteinModelPortaliP77731.
SMRiP77731. Positions 1-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77731.

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z2U. Bacteria.
COG3194. LUCA.
HOGENOMiHOG000256169.
InParanoidiP77731.
KOiK01483.
OMAiEMMERHP.
PhylomeDBiP77731.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
HAMAPiMF_00616. Ureidogly_lyase. 1 hit.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_lyase.
IPR023525. Ureidogly_lyase_bac.
IPR024060. Ureidoglycolate_lyase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P77731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD
60 70 80 90 100
CTLISINRAQ PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP
110 120 130 140 150
DLSTLRAFIT NGEQGVNYHR NVWHHPLFAW QRVTDFLTID RGGSDNCDVE
160
SIPEQELCFA
Length:160
Mass (Da):18,170
Last modified:February 1, 1997 - v1
Checksum:i88FDA2A7D48D6E97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89024 Genomic DNA. Translation: AAB93846.1.
U82664 Genomic DNA. Translation: AAB40258.1.
U00096 Genomic DNA. Translation: AAC73607.1.
AP009048 Genomic DNA. Translation: BAE76283.1.
PIRiH64781.
RefSeqiNP_415038.1. NC_000913.3.
WP_000776377.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73607; AAC73607; b0505.
BAE76283; BAE76283; BAE76283.
GeneIDi945141.
KEGGiecj:JW0493.
eco:b0505.
PATRICi32116169. VBIEscCol129921_0526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89024 Genomic DNA. Translation: AAB93846.1.
U82664 Genomic DNA. Translation: AAB40258.1.
U00096 Genomic DNA. Translation: AAC73607.1.
AP009048 Genomic DNA. Translation: BAE76283.1.
PIRiH64781.
RefSeqiNP_415038.1. NC_000913.3.
WP_000776377.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XSQX-ray1.60A/B1-160[»]
ProteinModelPortaliP77731.
SMRiP77731. Positions 1-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259861. 14 interactions.
IntActiP77731. 4 interactions.
STRINGi511145.b0505.

Proteomic databases

PaxDbiP77731.
PRIDEiP77731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73607; AAC73607; b0505.
BAE76283; BAE76283; BAE76283.
GeneIDi945141.
KEGGiecj:JW0493.
eco:b0505.
PATRICi32116169. VBIEscCol129921_0526.

Organism-specific databases

EchoBASEiEB3381.
EcoGeneiEG13615. allA.

Phylogenomic databases

eggNOGiENOG4108Z2U. Bacteria.
COG3194. LUCA.
HOGENOMiHOG000256169.
InParanoidiP77731.
KOiK01483.
OMAiEMMERHP.
PhylomeDBiP77731.

Enzyme and pathway databases

UniPathwayiUPA00395.
BioCyciEcoCyc:G6275-MONOMER.
ECOL316407:JW0493-MONOMER.
MetaCyc:G6275-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP77731.
PROiP77731.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
HAMAPiMF_00616. Ureidogly_lyase. 1 hit.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_lyase.
IPR023525. Ureidogly_lyase_bac.
IPR024060. Ureidoglycolate_lyase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLA_ECOLI
AccessioniPrimary (citable) accession number: P77731
Secondary accession number(s): Q2MBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.