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Reviewed, UniProtKB/Swiss-Prot P77731 (ALLA_ECOLI)

Last modified November 3, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ureidoglycolate hydrolase
    EC=3.5.3.19
Gene names
Name: allA
Synonyms: glxA2, ybbT
Ordered Locus Names: b0505, JW0493
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. Ref.1

Catalytic activity

(S)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2. HAMAP MF_00616

Pathway

Nitrogen metabolism; (S)-allantoin degradation; glyoxylate from (S)-ureidoglycolate: step 1/1. HAMAP MF_00616

Subunit structure

Homodimer. Ref.5

Induction

By glyoxylate and allantoin under anaerobic conditions and by glyoxylate under aerobic conditions. HAMAP MF_00616

Sequence similarities

Belongs to the ureidoglycolate hydrolase family.

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Ontologies

Keywords
   Biological processPurine metabolism
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processallantoin catabolic process

Inferred from electronic annotation. Source: InterPro

purine base catabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionureidoglycolate hydrolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 160160Ureidoglycolate hydrolase HAMAP MF_00616
PRO_0000120547

Secondary structure

1 ............................... 160
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P77731-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 88FDA2A7D48D6E97

FASTA16018,170
        10         20         30         40         50         60 
MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD CTLISINRAQ 

        70         80         90        100        110        120 
PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP DLSTLRAFIT NGEQGVNYHR 

       130        140        150        160 
NVWHHPLFAW QRVTDFLTID RGGSDNCDVE SIPEQELCFA

« Hide

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References

« Hide 'large scale' references
[1]"Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli."
Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.
J. Bacteriol. 181:7479-7484(1999) [PubMed: 10601204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: K12 / ECL1.
[2]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Crystal structure of ureidoglycolate hydrolase from E.coli. Northeast structural genomics consortium target Et81."
Northeast structural genomics consortium (NESG)
Submitted (JAN-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS), SUBUNIT.

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Cross-references

Sequence databases

U89024 Genomic DNA. Translation: AAB93846.1.
U82664 Genomic DNA. Translation: AAB40258.1.
U00096 Genomic DNA. Translation: AAC73607.1.
AP009048 Genomic DNA. Translation: BAE76283.1.
PIRH64781.
RefSeqAP_001153.1.
NP_415038.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1XSQX-ray1.60A/B1-160[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP77731.

Genome annotation databases

GeneID945141.
GenomeReviewsGene locus JW0493 in contig AP009048_GR.
Gene locus b0505 in contig U00096_GR.
KEGGecj:JW0493.
eco:b0505.

Organism-specific databases

EchoBASEEB3381.
EcoGeneEG13615. allA.
CMRSearch...

Phylogenomic databases

HOGENOMP77731.
OMAYRAGTWH.

Enzyme and pathway databases

BioCycEcoCyc:G6275-MON.
MetaCyc:G6275-MON.

Gene expression databases

GenevestigatorP77731.

Family and domain databases

HAMAPMF_00616.
[Tree]
InterProIPR007247. Ureidogly_hydro.
[Graphical view]
PANTHERPTHR21221. Ureidogly_hydro. 1 hit.
PfamPF04115. Ureidogly_hydro. 1 hit.
[Graphical view]
PIRSFPIRSF017306. Ureidogly_hydro. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameALLA_ECOLI
AccessionPrimary (citable) accession number: P77731
Secondary accession number(s): Q2MBS3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents