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Protein

Inner membrane transport protein YajR

Gene

yajR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • transmembrane transport Source: EcoCyc
  • transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0427-MONOMER.
ECOL316407:JW5059-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.60. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane transport protein YajR
Gene namesi
Name:yajR
Ordered Locus Names:b0427, JW5059
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13614. yajR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414PeriplasmicSequence analysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Topological domaini36 – 4712CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 8416PeriplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 13732CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 1657PeriplasmicSequence analysis
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Topological domaini187 – 21630CytoplasmicSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 25215PeriplasmicSequence analysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence analysisAdd
BLAST
Topological domaini274 – 2796CytoplasmicSequence analysis
Transmembranei280 – 30021HelicalSequence analysisAdd
BLAST
Topological domaini301 – 3066PeriplasmicSequence analysis
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Topological domaini328 – 34013CytoplasmicSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 3632PeriplasmicSequence analysis
Transmembranei364 – 38421HelicalSequence analysisAdd
BLAST
Topological domaini385 – 45470CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Inner membrane transport protein YajRPRO_0000173400Add
BLAST

Proteomic databases

PaxDbiP77726.
PRIDEiP77726.

Interactioni

Protein-protein interaction databases

BioGridi4263068. 176 interactions.
STRINGi511145.b0427.

Structurei

3D structure databases

ProteinModelPortaliP77726.
SMRiP77726. Positions 3-454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RDB. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000264695.
InParanoidiP77726.
OMAiPPYVTSL.
OrthoDBiEOG6T7N4X.
PhylomeDBiP77726.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDYKMTPGE RRATWGLGTV FSLRMLGMFM VLPVLTTYGM ALQGASEALI
60 70 80 90 100
GIAIGIYGLT QAVFQIPFGL LSDRIGRKPL IVGGLAVFAA GSVIAALSDS
110 120 130 140 150
IWGIILGRAL QGSGAIAAAV MALLSDLTRE QNRTKAMAFI GVSFGITFAI
160 170 180 190 200
AMVLGPIITH KLGLHALFWM IAILATTGIA LTIWVVPNSS THVLNRESGM
210 220 230 240 250
VKGSFSKVLA EPRLLKLNFG IMCLHILLMS TFVALPGQLA DAGFPAAEHW
260 270 280 290 300
KVYLATMLIA FGSVVPFIIY AEVKRKMKQV FVFCVGLIVV AEIVLWNAQT
310 320 330 340 350
QFWQLVVGVQ LFFVAFNLME ALLPSLISKE SPAGYKGTAM GVYSTSQFLG
360 370 380 390 400
VAIGGSLGGW INGMFDGQGV FLAGAMLAAV WLTVASTMKE PPYVSSLRIE
410 420 430 440 450
IPANIAANEA LKVRLLETEG IKEVLIAEEE HSAYVKIDSK VTNRFEIEQA

IRQA
Length:454
Mass (Da):48,810
Last modified:April 27, 2001 - v2
Checksum:iB35BD78EE75DE901
GO

Sequence cautioni

The sequence AAB40183.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40183.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73530.2.
AP009048 Genomic DNA. Translation: BAE76207.1.
PIRiC64772.
RefSeqiNP_414961.4. NC_000913.3.
WP_001000963.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73530; AAC73530; b0427.
BAE76207; BAE76207; BAE76207.
GeneIDi945058.
KEGGiecj:JW5059.
eco:b0427.
PATRICi32116005. VBIEscCol129921_0444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40183.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73530.2.
AP009048 Genomic DNA. Translation: BAE76207.1.
PIRiC64772.
RefSeqiNP_414961.4. NC_000913.3.
WP_001000963.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77726.
SMRiP77726. Positions 3-454.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263068. 176 interactions.
STRINGi511145.b0427.

Protein family/group databases

TCDBi2.A.1.2.60. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP77726.
PRIDEiP77726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73530; AAC73530; b0427.
BAE76207; BAE76207; BAE76207.
GeneIDi945058.
KEGGiecj:JW5059.
eco:b0427.
PATRICi32116005. VBIEscCol129921_0444.

Organism-specific databases

EchoBASEiEB3380.
EcoGeneiEG13614. yajR.

Phylogenomic databases

eggNOGiENOG4107RDB. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000264695.
InParanoidiP77726.
OMAiPPYVTSL.
OrthoDBiEOG6T7N4X.
PhylomeDBiP77726.

Enzyme and pathway databases

BioCyciEcoCyc:B0427-MONOMER.
ECOL316407:JW5059-MONOMER.

Miscellaneous databases

PROiP77726.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYAJR_ECOLI
AccessioniPrimary (citable) accession number: P77726
Secondary accession number(s): Q2MBZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 27, 2001
Last modified: January 20, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.