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Protein

Toxin YkfI

Gene

ykfI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Toxic component of a toxin-antitoxin (TA) system. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation; these effects are overcome by concomitant expression of antitoxin YafW, which leads to toxin loss by an unknown mechanism.1 Publication

GO - Biological processi

  • negative regulation of cell growth Source: EcoCyc

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:G6120-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin YkfI
Gene namesi
Name:ykfI
Ordered Locus Names:b0245, JW0234
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14333 ykfI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001685511 – 113Toxin YkfIAdd BLAST113

Proteomic databases

PaxDbiP77692
PRIDEiP77692

Interactioni

Protein-protein interaction databases

BioGridi4263161, 78 interactors
IntActiP77692, 3 interactors
STRINGi316385.ECDH10B_0227

Structurei

3D structure databases

ProteinModelPortaliP77692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbtA/YkfI/YpjF toxin family.Curated

Phylogenomic databases

eggNOGiENOG4108X3P Bacteria
ENOG4111PBJ LUCA
HOGENOMiHOG000124769
KOiK18837
OMAiWQEQSPF
PhylomeDBiP77692

Family and domain databases

InterProiView protein in InterPro
IPR009610 CbtA_toxin
PfamiView protein in Pfam
PF06755 CbtA_toxin, 1 hit

Sequencei

Sequence statusi: Complete.

P77692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLPAITQR AVKPCLSPVA VWQMLLTRLL EQHYGLTIND TPFCNEAVIK
60 70 80 90 100
EHIDAGITLA DAVNFLVEKY ELVRIDRKGF SWQEQSPYLR AADILRARQA
110
TGLLRQSRNN VVR
Length:113
Mass (Da):12,905
Last modified:February 1, 1997 - v1
Checksum:iD0B15FBC0BF731B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA Translation: AAB08664.1
U00096 Genomic DNA Translation: AAC73348.1
AP009048 Genomic DNA Translation: BAA77913.2
PIRiE64749
RefSeqiNP_414779.1, NC_000913.3
WP_000854672.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73348; AAC73348; b0245
BAA77913; BAA77913; BAA77913
GeneIDi946726
KEGGiecj:JW0234
eco:b0245
PATRICifig|1411691.4.peg.2038

Similar proteinsi

Entry informationi

Entry nameiYKFI_ECOLI
AccessioniPrimary (citable) accession number: P77692
Secondary accession number(s): Q9XB43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health