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Protein

Toxin YkfI

Gene

ykfI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation; these effects are overcome by concomitant expression of antitoxin YafW, which leads to toxin loss by an unknown mechanism.1 Publication

GO - Biological processi

  • negative regulation of cell growth Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Enzyme and pathway databases

BioCyciEcoCyc:G6120-MONOMER.
ECOL316407:JW0234-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin YkfI
Gene namesi
Name:ykfI
Ordered Locus Names:b0245, JW0234
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14333. ykfI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001685511 – 113Toxin YkfIAdd BLAST113

Proteomic databases

PaxDbiP77692.
PRIDEiP77692.

Interactioni

Protein-protein interaction databases

BioGridi4263161. 78 interactors.
IntActiP77692. 3 interactors.
STRINGi511145.b0245.

Structurei

3D structure databases

ProteinModelPortaliP77692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbtA/YkfI/YpjF toxin family.Curated

Phylogenomic databases

eggNOGiENOG4108X3P. Bacteria.
ENOG4111PBJ. LUCA.
HOGENOMiHOG000124769.
KOiK18837.
OMAiWQEQSPF.
PhylomeDBiP77692.

Family and domain databases

InterProiIPR009610. CbtA_toxin.
[Graphical view]
PfamiPF06755. CbtA_toxin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLPAITQR AVKPCLSPVA VWQMLLTRLL EQHYGLTIND TPFCNEAVIK
60 70 80 90 100
EHIDAGITLA DAVNFLVEKY ELVRIDRKGF SWQEQSPYLR AADILRARQA
110
TGLLRQSRNN VVR
Length:113
Mass (Da):12,905
Last modified:February 1, 1997 - v1
Checksum:iD0B15FBC0BF731B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08664.1.
U00096 Genomic DNA. Translation: AAC73348.1.
AP009048 Genomic DNA. Translation: BAA77913.2.
PIRiE64749.
RefSeqiNP_414779.1. NC_000913.3.
WP_000854672.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73348; AAC73348; b0245.
BAA77913; BAA77913; BAA77913.
GeneIDi946726.
KEGGiecj:JW0234.
eco:b0245.
PATRICi32115605. VBIEscCol129921_0246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08664.1.
U00096 Genomic DNA. Translation: AAC73348.1.
AP009048 Genomic DNA. Translation: BAA77913.2.
PIRiE64749.
RefSeqiNP_414779.1. NC_000913.3.
WP_000854672.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77692.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263161. 78 interactors.
IntActiP77692. 3 interactors.
STRINGi511145.b0245.

Proteomic databases

PaxDbiP77692.
PRIDEiP77692.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73348; AAC73348; b0245.
BAA77913; BAA77913; BAA77913.
GeneIDi946726.
KEGGiecj:JW0234.
eco:b0245.
PATRICi32115605. VBIEscCol129921_0246.

Organism-specific databases

EchoBASEiEB4079.
EcoGeneiEG14333. ykfI.

Phylogenomic databases

eggNOGiENOG4108X3P. Bacteria.
ENOG4111PBJ. LUCA.
HOGENOMiHOG000124769.
KOiK18837.
OMAiWQEQSPF.
PhylomeDBiP77692.

Enzyme and pathway databases

BioCyciEcoCyc:G6120-MONOMER.
ECOL316407:JW0234-MONOMER.

Miscellaneous databases

PROiP77692.

Family and domain databases

InterProiIPR009610. CbtA_toxin.
[Graphical view]
PfamiPF06755. CbtA_toxin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYKFI_ECOLI
AccessioniPrimary (citable) accession number: P77692
Secondary accession number(s): Q9XB43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.