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Protein

Toxin YkfI

Gene

ykfI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation; these effects are overcome by concomitant expression of antitoxin YafW, which leads to toxin loss by an unknown mechanism.1 Publication

GO - Biological processi

  • negative regulation of cell growth Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Enzyme and pathway databases

BioCyciEcoCyc:G6120-MONOMER.
ECOL316407:JW0234-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin YkfI
Gene namesi
Name:ykfI
Ordered Locus Names:b0245, JW0234
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14333. ykfI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Toxin YkfIPRO_0000168551Add
BLAST

Proteomic databases

PaxDbiP77692.

Interactioni

Protein-protein interaction databases

BioGridi4263161. 78 interactions.
IntActiP77692. 3 interactions.
STRINGi511145.b0245.

Structurei

3D structure databases

ProteinModelPortaliP77692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbtA/YkfI/YpjF toxin family.Curated

Phylogenomic databases

eggNOGiENOG4108X3P. Bacteria.
ENOG4111PBJ. LUCA.
HOGENOMiHOG000124769.
KOiK18837.
OMAiWQEQSPF.
OrthoDBiEOG6VF352.
PhylomeDBiP77692.

Family and domain databases

InterProiIPR009610. CbtA_toxin.
[Graphical view]
PfamiPF06755. CbtA_toxin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLPAITQR AVKPCLSPVA VWQMLLTRLL EQHYGLTIND TPFCNEAVIK
60 70 80 90 100
EHIDAGITLA DAVNFLVEKY ELVRIDRKGF SWQEQSPYLR AADILRARQA
110
TGLLRQSRNN VVR
Length:113
Mass (Da):12,905
Last modified:February 1, 1997 - v1
Checksum:iD0B15FBC0BF731B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08664.1.
U00096 Genomic DNA. Translation: AAC73348.1.
AP009048 Genomic DNA. Translation: BAA77913.2.
PIRiE64749.
RefSeqiNP_414779.1. NC_000913.3.
WP_000854672.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73348; AAC73348; b0245.
BAA77913; BAA77913; BAA77913.
GeneIDi946726.
KEGGiecj:JW0234.
eco:b0245.
PATRICi32115605. VBIEscCol129921_0246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08664.1.
U00096 Genomic DNA. Translation: AAC73348.1.
AP009048 Genomic DNA. Translation: BAA77913.2.
PIRiE64749.
RefSeqiNP_414779.1. NC_000913.3.
WP_000854672.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77692.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263161. 78 interactions.
IntActiP77692. 3 interactions.
STRINGi511145.b0245.

Proteomic databases

PaxDbiP77692.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73348; AAC73348; b0245.
BAA77913; BAA77913; BAA77913.
GeneIDi946726.
KEGGiecj:JW0234.
eco:b0245.
PATRICi32115605. VBIEscCol129921_0246.

Organism-specific databases

EchoBASEiEB4079.
EcoGeneiEG14333. ykfI.

Phylogenomic databases

eggNOGiENOG4108X3P. Bacteria.
ENOG4111PBJ. LUCA.
HOGENOMiHOG000124769.
KOiK18837.
OMAiWQEQSPF.
OrthoDBiEOG6VF352.
PhylomeDBiP77692.

Enzyme and pathway databases

BioCyciEcoCyc:G6120-MONOMER.
ECOL316407:JW0234-MONOMER.

Miscellaneous databases

PROiP77692.

Family and domain databases

InterProiIPR009610. CbtA_toxin.
[Graphical view]
PfamiPF06755. CbtA_toxin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "A novel family of Escherichia coli toxin-antitoxin gene pairs."
    Brown J.M., Shaw K.J.
    J. Bacteriol. 185:6600-6608(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TOXIN.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYKFI_ECOLI
AccessioniPrimary (citable) accession number: P77692
Secondary accession number(s): Q9XB43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 13, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.