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Protein

FeS cluster assembly protein SufD

Gene

sufD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein.2 Publications

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoCyc
  • response to oxidative stress Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6907-MONOMER.
ECOL316407:JW1671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FeS cluster assembly protein SufD
Gene namesi
Name:sufD
Synonyms:ynhC
Ordered Locus Names:b1681, JW1671
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13963. sufD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001473751 – 423FeS cluster assembly protein SufDAdd BLAST423

Proteomic databases

PaxDbiP77689.
PRIDEiP77689.

Interactioni

Subunit structurei

Part of the SufBCD complex that contains SufB, SufC and SufD. Can form homodimers.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
sufBP7752213EBI-562751,EBI-562758
sufCP774998EBI-562751,EBI-561601

Protein-protein interaction databases

BioGridi4260280. 76 interactors.
DIPiDIP-10940N.
IntActiP77689. 8 interactors.
MINTiMINT-7290848.
STRINGi511145.b1681.

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 19Combined sources10
Helixi27 – 39Combined sources13
Beta strandi50 – 52Combined sources3
Helixi55 – 58Combined sources4
Beta strandi59 – 63Combined sources5
Helixi71 – 77Combined sources7
Beta strandi83 – 89Combined sources7
Helixi95 – 97Combined sources3
Turni102 – 105Combined sources4
Beta strandi107 – 112Combined sources6
Helixi125 – 133Combined sources9
Beta strandi137 – 142Combined sources6
Beta strandi152 – 158Combined sources7
Beta strandi162 – 164Combined sources3
Beta strandi166 – 177Combined sources12
Beta strandi182 – 195Combined sources14
Beta strandi197 – 207Combined sources11
Beta strandi212 – 219Combined sources8
Beta strandi226 – 235Combined sources10
Beta strandi240 – 247Combined sources8
Beta strandi251 – 261Combined sources11
Beta strandi263 – 265Combined sources3
Beta strandi267 – 274Combined sources8
Beta strandi281 – 290Combined sources10
Beta strandi292 – 294Combined sources3
Beta strandi296 – 305Combined sources10
Beta strandi310 – 319Combined sources10
Beta strandi326 – 336Combined sources11
Beta strandi338 – 340Combined sources3
Beta strandi342 – 351Combined sources10
Beta strandi354 – 365Combined sources12
Helixi369 – 377Combined sources9
Helixi382 – 398Combined sources17
Helixi399 – 401Combined sources3
Helixi404 – 415Combined sources12
Turni419 – 421Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VH4X-ray1.75A/B1-423[»]
2ZU0X-ray2.20A/B1-423[»]
5AWFX-ray2.96B/F1-423[»]
5AWGX-ray4.28B/F1-423[»]
ProteinModelPortaliP77689.
SMRiP77689.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77689.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0051 (ycf24) family.Curated

Phylogenomic databases

eggNOGiENOG4105JRK. Bacteria.
COG0719. LUCA.
HOGENOMiHOG000069113.
InParanoidiP77689.
KOiK09015.
OMAiVLRHHTS.
PhylomeDBiP77689.

Family and domain databases

InterProiIPR000825. SUF_FeS_clus_asmbl_SufBD.
IPR011542. SUF_FeS_clus_asmbl_SufD.
[Graphical view]
PfamiPF01458. UPF0051. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01981. sufD. 1 hit.

Sequencei

Sequence statusi: Complete.

P77689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLPNSSNA LQQWHHLFEA EGTKRSPQAQ QHLQQLLRTG LPTRKHENWK
60 70 80 90 100
YTPLEGLINS QFVSIAGEIS PQQRDALALT LDSVRLVFVD GRYVPALSDA
110 120 130 140 150
TEGSGYEVSI NDDRQGLPDA IQAEVFLHLT ESLAQSVTHI AVKRGQRPAK
160 170 180 190 200
PLLLMHITQG VAGEEVNTAH YRHHLDLAEG AEATVIEHFV SLNDARHFTG
210 220 230 240 250
ARFTINVAAN AHLQHIKLAF ENPLSHHFAH NDLLLAEDAT AFSHSFLLGG
260 270 280 290 300
AVLRHNTSTQ LNGENSTLRI NSLAMPVKNE VCDTRTWLEH NKGFCNSRQL
310 320 330 340 350
HKTIVSDKGR AVFNGLINVA QHAIKTDGQM TNNNLLMGKL AEVDTKPQLE
360 370 380 390 400
IYADDVKCSH GATVGRIDDE QIFYLRSRGI NQQDAQQMII YAFAAELTEA
410 420
LRDEGLKQQV LARIGQRLPG GAR
Length:423
Mass (Da):46,823
Last modified:February 1, 1997 - v1
Checksum:i5744291F1E0AE825
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74751.1.
AP009048 Genomic DNA. Translation: BAA15456.1.
PIRiA64926.
RefSeqiNP_416196.1. NC_000913.3.
WP_000907979.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74751; AAC74751; b1681.
BAA15456; BAA15456; BAA15456.
GeneIDi944878.
KEGGiecj:JW1671.
eco:b1681.
PATRICi32118668. VBIEscCol129921_1752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74751.1.
AP009048 Genomic DNA. Translation: BAA15456.1.
PIRiA64926.
RefSeqiNP_416196.1. NC_000913.3.
WP_000907979.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VH4X-ray1.75A/B1-423[»]
2ZU0X-ray2.20A/B1-423[»]
5AWFX-ray2.96B/F1-423[»]
5AWGX-ray4.28B/F1-423[»]
ProteinModelPortaliP77689.
SMRiP77689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260280. 76 interactors.
DIPiDIP-10940N.
IntActiP77689. 8 interactors.
MINTiMINT-7290848.
STRINGi511145.b1681.

Proteomic databases

PaxDbiP77689.
PRIDEiP77689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74751; AAC74751; b1681.
BAA15456; BAA15456; BAA15456.
GeneIDi944878.
KEGGiecj:JW1671.
eco:b1681.
PATRICi32118668. VBIEscCol129921_1752.

Organism-specific databases

EchoBASEiEB3721.
EcoGeneiEG13963. sufD.

Phylogenomic databases

eggNOGiENOG4105JRK. Bacteria.
COG0719. LUCA.
HOGENOMiHOG000069113.
InParanoidiP77689.
KOiK09015.
OMAiVLRHHTS.
PhylomeDBiP77689.

Enzyme and pathway databases

BioCyciEcoCyc:G6907-MONOMER.
ECOL316407:JW1671-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP77689.
PROiP77689.

Family and domain databases

InterProiIPR000825. SUF_FeS_clus_asmbl_SufBD.
IPR011542. SUF_FeS_clus_asmbl_SufD.
[Graphical view]
PfamiPF01458. UPF0051. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01981. sufD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUFD_ECOLI
AccessioniPrimary (citable) accession number: P77689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.