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Protein

Bactoprenol-linked glucose translocase homolog from prophage CPS-53

Gene

yfdG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity).By similarity

GO - Molecular functioni

  • 5-aminolevulinate synthase activity Source: EcoliWiki
  • catalytic activity Source: EcoliWiki
  • glutamyl-tRNA reductase activity Source: EcoliWiki
  • NADP binding Source: EcoliWiki

GO - Biological processi

  • heme biosynthetic process Source: EcoliWiki
  • polysaccharide biosynthetic process Source: InterPro
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7219-MONOMER.
ECOL316407:JW2346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bactoprenol-linked glucose translocase homolog from prophage CPS-53
Gene namesi
Name:yfdG
Ordered Locus Names:b2350, JW2346
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14131. yfdG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 333PeriplasmicSequence analysis
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 6410CytoplasmicSequence analysis
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Topological domaini86 – 883PeriplasmicSequence analysis
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 12011CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Bactoprenol-linked glucose translocase homolog from prophage CPS-53PRO_0000212252Add
BLAST

Proteomic databases

PaxDbiP77682.
PRIDEiP77682.

Interactioni

Protein-protein interaction databases

BioGridi4260541. 149 interactions.
STRINGi511145.b2350.

Structurei

3D structure databases

ProteinModelPortaliP77682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GtrA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105IHM. Bacteria.
COG2246. LUCA.
HOGENOMiHOG000005085.
OMAiSTTAMRY.
OrthoDBiEOG6KT2RC.

Family and domain databases

InterProiIPR016480. Glc_translocase_bactprenl-link.
IPR007267. GtrA.
[Graphical view]
PfamiPF04138. GtrA. 1 hit.
[Graphical view]
PIRSFiPIRSF006298. GtrA_prd. 1 hit.

Sequencei

Sequence statusi: Complete.

P77682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLFAKYTS IGVLNTLIHW VVFGVCIYVA HTNQALANFA GFVVAVSFSF
60 70 80 90 100
FANAKFTFKA STTTMRYMLY VGFMGTLSAT VGWAADRCAL PPMITLVTFS
110 120
AISLVCGFVY SKFIVFRDAK
Length:120
Mass (Da):13,226
Last modified:February 1, 1997 - v1
Checksum:i881A6B5614875C5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75409.1.
AP009048 Genomic DNA. Translation: BAA16209.1.
PIRiC65008.
RefSeqiNP_416851.1. NC_000913.3.
WP_000915541.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75409; AAC75409; b2350.
BAA16209; BAA16209; BAA16209.
GeneIDi948821.
KEGGiecj:JW2346.
eco:b2350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75409.1.
AP009048 Genomic DNA. Translation: BAA16209.1.
PIRiC65008.
RefSeqiNP_416851.1. NC_000913.3.
WP_000915541.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260541. 149 interactions.
STRINGi511145.b2350.

Proteomic databases

PaxDbiP77682.
PRIDEiP77682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75409; AAC75409; b2350.
BAA16209; BAA16209; BAA16209.
GeneIDi948821.
KEGGiecj:JW2346.
eco:b2350.

Organism-specific databases

EchoBASEiEB3883.
EcoGeneiEG14131. yfdG.

Phylogenomic databases

eggNOGiENOG4105IHM. Bacteria.
COG2246. LUCA.
HOGENOMiHOG000005085.
OMAiSTTAMRY.
OrthoDBiEOG6KT2RC.

Enzyme and pathway databases

BioCyciEcoCyc:G7219-MONOMER.
ECOL316407:JW2346-MONOMER.

Miscellaneous databases

PROiP77682.

Family and domain databases

InterProiIPR016480. Glc_translocase_bactprenl-link.
IPR007267. GtrA.
[Graphical view]
PfamiPF04138. GtrA. 1 hit.
[Graphical view]
PIRSFiPIRSF006298. GtrA_prd. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiGTRA_ECOLI
AccessioniPrimary (citable) accession number: P77682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.