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Protein

Autoinducer 2 import system permease protein LsrC

Gene

lsrC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDEY-MONOMER.
ECOL316407:JW1507-MONOMER.
MetaCyc:YDEY-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Autoinducer 2 import system permease protein LsrC
Short name:
AI-2 import system permease protein LsrC
Gene namesi
Name:lsrC
Synonyms:ydeY
Ordered Locus Names:b1514, JW1507
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13807. lsrC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313PeriplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 384CytoplasmicSequence analysis
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Topological domaini60 – 6910PeriplasmicSequence analysis
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 922CytoplasmicSequence analysis
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 1141PeriplasmicSequence analysis
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 15621CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 21235PeriplasmicSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Topological domaini234 – 25118CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 28311PeriplasmicSequence analysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence analysisAdd
BLAST
Topological domaini305 – 34238CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Autoinducer 2 import system permease protein LsrCPRO_0000060247Add
BLAST

Proteomic databases

PaxDbiP77672.

Expressioni

Inductioni

In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter.2 Publications

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).Curated

Protein-protein interaction databases

BioGridi4260227. 9 interactions.
DIPiDIP-11689N.
STRINGi511145.b1514.

Structurei

3D structure databases

ProteinModelPortaliP77672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41071MT. Bacteria.
COG1172. LUCA.
HOGENOMiHOG000212232.
InParanoidiP77672.
KOiK10556.
OMAiKRMLKMH.
OrthoDBiEOG61P6T8.
PhylomeDBiP77672.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFIQNNRE ITALLAVVLL FVLPGFLDRQ YLSVQTLTMV YSSAQILILL
60 70 80 90 100
AMGATLVMLT RNIDVSVGSI TGMCAVLLGM LLNAGYSLPV ACVATLLLGL
110 120 130 140 150
LAGFFNGVLV AWLKIPAIVA TLGTLGLYRG IMLLWTGGKW IEGLPAELKQ
160 170 180 190 200
LSAPLLLGVS AIGWLTIILV AFMAWLLAKT AFGRSFYATG DNLQGARQLG
210 220 230 240 250
VRTEAIRIVA FSLNGCMAAL AGIVFASQIG FIPNQTGTGL EMKAIAACVL
260 270 280 290 300
GGISLLGGSG AIIGAVLGAW FLTQIDSVLV LLRIPAWWND FIAGLVLLAV
310 320 330 340
LVFDGRLRCA LERNLRRQKY ARFMTPPPSV KPASSGKKRE AA
Length:342
Mass (Da):36,395
Last modified:February 1, 1997 - v1
Checksum:i419E505026ABDE33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74587.1.
AP009048 Genomic DNA. Translation: BAA15201.1.
PIRiE64905.
RefSeqiNP_416031.1. NC_000913.3.
WP_000911184.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74587; AAC74587; b1514.
BAA15201; BAA15201; BAA15201.
GeneIDi946105.
KEGGiecj:JW1507.
eco:b1514.
PATRICi32118324. VBIEscCol129921_1582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74587.1.
AP009048 Genomic DNA. Translation: BAA15201.1.
PIRiE64905.
RefSeqiNP_416031.1. NC_000913.3.
WP_000911184.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77672.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260227. 9 interactions.
DIPiDIP-11689N.
STRINGi511145.b1514.

Protein family/group databases

TCDBi3.A.1.2.8. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP77672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74587; AAC74587; b1514.
BAA15201; BAA15201; BAA15201.
GeneIDi946105.
KEGGiecj:JW1507.
eco:b1514.
PATRICi32118324. VBIEscCol129921_1582.

Organism-specific databases

EchoBASEiEB3568.
EcoGeneiEG13807. lsrC.

Phylogenomic databases

eggNOGiENOG41071MT. Bacteria.
COG1172. LUCA.
HOGENOMiHOG000212232.
InParanoidiP77672.
KOiK10556.
OMAiKRMLKMH.
OrthoDBiEOG61P6T8.
PhylomeDBiP77672.

Enzyme and pathway databases

BioCyciEcoCyc:YDEY-MONOMER.
ECOL316407:JW1507-MONOMER.
MetaCyc:YDEY-MONOMER.

Miscellaneous databases

PROiP77672.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli."
    Xavier K.B., Bassler B.L.
    J. Bacteriol. 187:238-248(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN AI-2 IMPORT, INDUCTION.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli."
    Wang L., Hashimoto Y., Tsao C.-Y., Valdes J.J., Bentley W.E.
    J. Bacteriol. 187:2066-2076(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiLSRC_ECOLI
AccessioniPrimary (citable) accession number: P77672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.