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Protein

HTH-type transcriptional regulator SutR

Gene

sutR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the expression of 12-16 transcription units involved in various steps of sulfur utilization. Represses expression of pfkB, fliZ, cysE, ydcO and its own expression. Activates expression of ypfN. Acts by binding to SutR boxes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi23 – 4220H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • sequence-specific DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6745-MONOMER.
ECOL316407:JW1430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator SutRCurated
Alternative name(s):
Sulfur utilization regulator1 Publication
Gene namesi
Name:sutR1 Publication
Synonyms:ydcN
Ordered Locus Names:b1434, JW1430
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13757. ydcN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178HTH-type transcriptional regulator SutRPRO_0000149756Add
BLAST

Proteomic databases

PaxDbiP77626.

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260184. 6 interactions.
DIPiDIP-11649N.
STRINGi511145.b1434.

Structurei

3D structure databases

ProteinModelPortaliP77626.
SMRiP77626. Positions 8-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 6655HTH cro/C1-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH cro/C1-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JCI. Bacteria.
COG1396. LUCA.
HOGENOMiHOG000263462.
InParanoidiP77626.
OMAiHYERLSE.
OrthoDBiEOG615VS0.
PhylomeDBiP77626.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR013096. Cupin_2.
IPR010982. Lambda_DNA-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 1 hit.
PF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLARFLST TLKQLRQQRG WSLSRLAEAT GVSKAMLGQI ERNESSPTVA
60 70 80 90 100
TLWKIATGLN VPFSTFISPP QSATPSVYDP QQQAMVITSL FPYDPQLCFE
110 120 130 140 150
HFSIQMASGA ISESTPHEKG VIEHVVVIDG QLDLCVDGEW QTLNCGEGVR
160 170
FAADVTHIYR NGGEQTVHFH SLIHYPRS
Length:178
Mass (Da):19,731
Last modified:February 1, 1997 - v1
Checksum:i64AD5A4B42325855
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74516.1.
AP009048 Genomic DNA. Translation: BAA15062.1.
PIRiE64895.
RefSeqiNP_415951.1. NC_000913.3.
WP_000429155.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74516; AAC74516; b1434.
BAA15062; BAA15062; BAA15062.
GeneIDi946000.
KEGGiecj:JW1430.
eco:b1434.
PATRICi32118158. VBIEscCol129921_1499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74516.1.
AP009048 Genomic DNA. Translation: BAA15062.1.
PIRiE64895.
RefSeqiNP_415951.1. NC_000913.3.
WP_000429155.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77626.
SMRiP77626. Positions 8-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260184. 6 interactions.
DIPiDIP-11649N.
STRINGi511145.b1434.

Proteomic databases

PaxDbiP77626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74516; AAC74516; b1434.
BAA15062; BAA15062; BAA15062.
GeneIDi946000.
KEGGiecj:JW1430.
eco:b1434.
PATRICi32118158. VBIEscCol129921_1499.

Organism-specific databases

EcoGeneiEG13757. ydcN.

Phylogenomic databases

eggNOGiENOG4108JCI. Bacteria.
COG1396. LUCA.
HOGENOMiHOG000263462.
InParanoidiP77626.
OMAiHYERLSE.
OrthoDBiEOG615VS0.
PhylomeDBiP77626.

Enzyme and pathway databases

BioCyciEcoCyc:G6745-MONOMER.
ECOL316407:JW1430-MONOMER.

Miscellaneous databases

PROiP77626.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR013096. Cupin_2.
IPR010982. Lambda_DNA-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 1 hit.
PF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli."
    Yamamoto K., Nakano M., Ishihama A.
    Microbiology 161:99-111(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, INDUCTION.
    Strain: K12.

Entry informationi

Entry nameiSUTR_ECOLI
AccessioniPrimary (citable) accession number: P77626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.