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Protein

Probable D,D-dipeptide transport ATP-binding protein DdpF

Gene

ddpF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 568ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YDDO-MONOMER.
ECOL316407:JW1478-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D,D-dipeptide transport ATP-binding protein DdpF
Gene namesi
Name:ddpF
Synonyms:yddO
Ordered Locus Names:b1483, JW1478
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13786. ddpF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Probable D,D-dipeptide transport ATP-binding protein DdpFPRO_0000093164Add
BLAST

Proteomic databases

PaxDbiP77622.

Expressioni

Inductioni

Induced by RpoS in stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA).Curated

Protein-protein interaction databases

BioGridi4260961. 99 interactions.
IntActiP77622. 2 interactions.
STRINGi511145.b1483.

Structurei

3D structure databases

ProteinModelPortaliP77622.
SMRiP77622. Positions 5-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 243236ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107H6U. Bacteria.
COG1124. LUCA.
InParanoidiP77622.
KOiK02032.
OMAiNPSMNVF.
OrthoDBiEOG6T7N3V.
PhylomeDBiP77622.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013563. Oligopep_ABC_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF08352. oligo_HPY. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01727. oligo_HPY. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTLLTLRD VHINFPARKN WLGKTTEHVH AINGIDLQIR RGETLGIVGE
60 70 80 90 100
SGCGKSTLAQ LLMGMLQPSH GQYIRSGSQR IMQMVFQDPL SSLNPRLPVW
110 120 130 140 150
RIITEPLWIA KRSSEQQRRA LAEELAVQVG IRPEYLDRLP HAFSGGQRQR
160 170 180 190 200
IAIARALSSQ PDVIVLDEPT SALDISVQAQ ILNLLVTLQE NHGLTYVLIS
210 220 230 240 250
HNVSVIRHMS DRVAVMYLGQ IVELGDAQQV LTAPAHPYTR LLLDSLPAID
260 270 280 290 300
KPLEEEWALR KTDLPGNRTL PQGCFFYERC PLATHGCEVR QSLAIREDGR

ELRCWRAL
Length:308
Mass (Da):34,621
Last modified:February 1, 1997 - v1
Checksum:iE7E17DD361EC07BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74556.1.
AP009048 Genomic DNA. Translation: BAA15138.1.
PIRiF64901.
RefSeqiNP_416000.1. NC_000913.3.
WP_001285536.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74556; AAC74556; b1483.
BAA15138; BAA15138; BAA15138.
GeneIDi946020.
KEGGiecj:JW1478.
eco:b1483.
PATRICi32118260. VBIEscCol129921_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74556.1.
AP009048 Genomic DNA. Translation: BAA15138.1.
PIRiF64901.
RefSeqiNP_416000.1. NC_000913.3.
WP_001285536.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77622.
SMRiP77622. Positions 5-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260961. 99 interactions.
IntActiP77622. 2 interactions.
STRINGi511145.b1483.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP77622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74556; AAC74556; b1483.
BAA15138; BAA15138; BAA15138.
GeneIDi946020.
KEGGiecj:JW1478.
eco:b1483.
PATRICi32118260. VBIEscCol129921_1550.

Organism-specific databases

EchoBASEiEB3547.
EcoGeneiEG13786. ddpF.

Phylogenomic databases

eggNOGiENOG4107H6U. Bacteria.
COG1124. LUCA.
InParanoidiP77622.
KOiK02032.
OMAiNPSMNVF.
OrthoDBiEOG6T7N3V.
PhylomeDBiP77622.

Enzyme and pathway databases

BioCyciEcoCyc:YDDO-MONOMER.
ECOL316407:JW1478-MONOMER.

Miscellaneous databases

PROiP77622.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013563. Oligopep_ABC_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF08352. oligo_HPY. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01727. oligo_HPY. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function."
    Lessard I.A.D., Pratt S.D., McCafferty D.G., Bussiere D.E., Hutchins C., Wanner B.L., Katz L., Walsh C.T.
    Chem. Biol. 5:489-504(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?"
    Lessard I.A.D., Walsh C.T.
    Proc. Natl. Acad. Sci. U.S.A. 96:11028-11032(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.

Entry informationi

Entry nameiDDPF_ECOLI
AccessioniPrimary (citable) accession number: P77622
Secondary accession number(s): P76870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.