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Protein

Probable fimbrial chaperone YfcS

Gene

yfcS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processFimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G7207-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone YfcS
Gene namesi
Name:yfcS
Ordered Locus Names:b2336, JW2333
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14122 yfcS

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000929429 – 250Probable fimbrial chaperone YfcSAdd BLAST222

Proteomic databases

PaxDbiP77599
PRIDEiP77599

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260521, 18 interactors
IntActiP77599, 1 interactor
STRINGi316385.ECDH10B_2498

Structurei

3D structure databases

ProteinModelPortaliP77599
SMRiP77599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108FZ9 Bacteria
COG3121 LUCA
HOGENOMiHOG000260153
OMAiDNPWQEK
PhylomeDBiP77599

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR008962 PapD-like_sf
IPR036316 Pili_assmbl_chap_C_dom_sf
IPR001829 Pili_assmbl_chaperone_bac
IPR016148 Pili_assmbl_chaperone_C
IPR018046 Pili_assmbl_chaperone_CS
IPR016147 Pili_assmbl_chaperone_N
PfamiView protein in Pfam
PF02753 PapD_C, 1 hit
PF00345 PapD_N, 1 hit
PRINTSiPR00969 CHAPERONPILI
SUPFAMiSSF49354 SSF49354, 1 hit
SSF49584 SSF49584, 1 hit
PROSITEiView protein in PROSITE
PS00635 PILI_CHAPERONE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLLCSAKL GAMTLALLLS ATSLSALASV TPDRTRLIFN ESDKSISVTL
60 70 80 90 100
RNNDPKLPYL AQSWIEDEKG NKITSPLTVL PPVQRIDSMM NGQVKVQGMP
110 120 130 140 150
DINKLPADRE SMFYFNVREI PPKSNKPNTL QIALQTRIKL FWRPKALEKV
160 170 180 190 200
SMKSPWQHKV TLTRSGQAFT VNNPTPYYVI ISNASAQKNG NPAAGFSPLV
210 220 230 240 250
IEPKTTVPLN VKMDSVPVLT YVNDFGARMP LFFQCNGNSC QVDEEQSRKG
Length:250
Mass (Da):27,728
Last modified:February 1, 1997 - v1
Checksum:i4FF723C1E9A3ECDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75396.1
AP009048 Genomic DNA Translation: BAA16190.1
PIRiF65006
RefSeqiNP_416839.1, NC_000913.3
WP_001281606.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75396; AAC75396; b2336
BAA16190; BAA16190; BAA16190
GeneIDi946418
KEGGiecj:JW2333
eco:b2336
PATRICifig|1411691.4.peg.4396

Similar proteinsi

Entry informationi

Entry nameiYFCS_ECOLI
AccessioniPrimary (citable) accession number: P77599
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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