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Protein

D-xylonate dehydratase YagF

Gene

yagF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of D-xylonic acid to form 2-dehydro-3-deoxy-D-pentonate.1 Publication

Catalytic activityi

D-xylonate = 2-dehydro-3-deoxy-D-xylonate + H2O.1 Publication

GO - Molecular functioni

  • xylonate dehydratase activity Source: EcoCyc

GO - Biological processi

  • aldonic acid catabolic process Source: EcoCyc

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciEcoCyc:G6141-MONOMER.
MetaCyc:G6141-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-xylonate dehydratase YagFCurated (EC:4.2.1.821 Publication)
Gene namesi
Name:yagF
Ordered Locus Names:b0269, JW0262
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13345. yagF.

Pathology & Biotechi

Disruption phenotypei

Disruption mutant has reduced ability to catabolize D-xylonic acid. YjhG-yagF double mutant cannot use D-xylonate as the sole source of carbon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001035601 – 655D-xylonate dehydratase YagFAdd BLAST655

Proteomic databases

PaxDbiP77596.
PRIDEiP77596.

Interactioni

Protein-protein interaction databases

BioGridi4261825. 9 interactors.
STRINGi316385.ECDH10B_0256.

Structurei

3D structure databases

ProteinModelPortaliP77596.
SMRiP77596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.Curated

Phylogenomic databases

eggNOGiENOG4105C01. Bacteria.
COG0129. LUCA.
HOGENOMiHOG000173155.
KOiK22396.
OMAiKPSACAP.
PhylomeDBiP77596.

Family and domain databases

InterProiView protein in InterPro
IPR017798. Dehydratase_YjhG/YagF.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
IPR037237. IlvD/EDD_N.
PfamiView protein in Pfam
PF00920. ILVD_EDD. 1 hit.
SUPFAMiSSF143975. SSF143975. 1 hit.
TIGRFAMsiTIGR03432. yjhG_yagF. 1 hit.
PROSITEiView protein in PROSITE
PS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P77596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIEKIFTPQ DDAFYAVITH AAGPQGALPL TPQMLMESPS GNLFGMTQNA
60 70 80 90 100
GMGWDANKLT GKEVLIIGTQ GGIRAGDGRP IALGYHTGHW EIGMQMQAAA
110 120 130 140 150
KEITRNGGIP FAAFVSDPCD GRSQGTHGMF DSLPYRNDAA IVFRRLIRSL
160 170 180 190 200
PTRRAVIGVA TCDKGLPATM IALAAMHDLP TILVPGGATL PPTVGEDAGK
210 220 230 240 250
VQTIGARFAN HELSLQEAAE LGCRACASPG GGCQFLGTAG TSQVVAEALG
260 270 280 290 300
LALPHSALAP SGQAVWLEIA RQSARAVSEL DSRGITTRDI LSDKAIENAM
310 320 330 340 350
VIHAAFGGST NLLLHIPAIA HAAGCTIPDV EHWTRINRKV PRLVSVLPNG
360 370 380 390 400
PDYHPTVRAF LAGGVPEVML HLRDLGLLHL DAMTVTGQTV GENLEWWQAS
410 420 430 440 450
ERRARFRQCL REQDGVEPDD VILPPEKAKA KGLTSTVCFP TGNIAPEGSV
460 470 480 490 500
IKATAIDPSV VGEDGVYHHT GRVRVFVSEA QAIKAIKREE IVQGDIMVVI
510 520 530 540 550
GGGPSGTGME ETYQLTSALK HISWGKTVSL ITDARFSGVS TGACFGHVSP
560 570 580 590 600
EALAGGPIGK LRDNDIIEIA VDRLTLTGSV NFIGTADNPL TPEEGARELA
610 620 630 640 650
RRQTHPDLHA HDFLPDDTRL WAALQSVSGG TWKGCIYDTD KIIEVINAGK

KALGI
Length:655
Mass (Da):69,399
Last modified:February 1, 1997 - v1
Checksum:i208AF2F6DB39EE8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA. Translation: AAB08690.1.
U00096 Genomic DNA. Translation: AAC73372.1.
AP009048 Genomic DNA. Translation: BAE76053.1.
PIRiE64752.
RefSeqiNP_414803.1. NC_000913.3.
WP_000151261.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73372; AAC73372; b0269.
BAE76053; BAE76053; BAE76053.
GeneIDi944928.
KEGGiecj:JW0262.
eco:b0269.
PATRICifig|511145.12.peg.273.

Similar proteinsi

Entry informationi

Entry nameiYAGF_ECOLI
AccessioniPrimary (citable) accession number: P77596
Secondary accession number(s): Q2MCF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome