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P77581

- ASTC_ECOLI

UniProt

P77581 - ASTC_ECOLI

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Protein

Succinylornithine transaminase

Gene
astC, argM, cstC, ydjW, b1748, JW1737
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase.1 Publication

Catalytic activityi

N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
  2. succinylornithine transaminase activity Source: EcoliWiki

GO - Biological processi

  1. arginine catabolic process Source: EcoliWiki
  2. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  3. arginine catabolic process to succinate Source: EcoCyc
  4. ornithine catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:SUCCORNTRANSAM-MONOMER.
ECOL316407:JW1737-MONOMER.
MetaCyc:SUCCORNTRANSAM-MONOMER.
UniPathwayiUPA00185; UER00281.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylornithine transaminase (EC:2.6.1.81)
Short name:
SOAT
Alternative name(s):
Carbon starvation protein C
Succinylornithine aminotransferase
Gene namesi
Name:astC
Synonyms:argM, cstC, ydjW
Ordered Locus Names:b1748, JW1737
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13999. argM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Succinylornithine transaminaseUniRule annotationPRO_0000120352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei252 – 2521N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiP77581.
PRIDEiP77581.

Expressioni

Gene expression databases

GenevestigatoriP77581.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
groLP0A6F51EBI-1125336,EBI-543750

Protein-protein interaction databases

DIPiDIP-9145N.
IntActiP77581. 2 interactions.
STRINGi511145.b1748.

Structurei

Secondary structure

1
406
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 137
Beta strandi25 – 306
Beta strandi32 – 354
Beta strandi40 – 456
Helixi46 – 494
Helixi58 – 6811
Helixi81 – 9313
Beta strandi97 – 1048
Helixi105 – 12319
Beta strandi130 – 1345
Helixi143 – 1486
Helixi152 – 1543
Helixi156 – 1583
Beta strandi163 – 1686
Helixi173 – 1775
Beta strandi184 – 1896
Beta strandi191 – 1933
Turni194 – 1974
Beta strandi198 – 2003
Helixi203 – 21513
Beta strandi219 – 2235
Turni225 – 2328
Beta strandi233 – 2364
Helixi237 – 2415
Beta strandi246 – 2505
Helixi252 – 2554
Beta strandi261 – 2655
Helixi267 – 2715
Helixi286 – 29914
Helixi302 – 32625
Beta strandi329 – 3357
Beta strandi338 – 3436
Turni345 – 3495
Helixi351 – 36010
Beta strandi366 – 3694
Beta strandi372 – 3754
Helixi383 – 40119

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ADBX-ray2.20A/B/C/D1-406[»]
4ADCX-ray2.30A/B/C/D1-406[»]
4ADDX-ray2.45A/B/C/D1-406[»]
4ADEX-ray2.75A/B1-406[»]
ProteinModelPortaliP77581.
SMRiP77581. Positions 3-403.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4992.
HOGENOMiHOG000020206.
KOiK00840.
OMAiASNAFLH.
OrthoDBiEOG6QVRHN.
PhylomeDBiP77581.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
MF_01173. AstC_aminotrans_3.
InterProiIPR017652. Ac/SucOrn_transaminase_bac.
IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR026330. SOAT.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03246. arg_catab_astC. 1 hit.
TIGR00707. argD. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77581-1 [UniParc]FASTAAdd to Basket

« Hide

MSQPITRENF DEWMIPVYAP APFIPVRGEG SRLWDQQGKE YIDFAGGIAV    50
NALGHAHPEL REALNEQASK FWHTGNGYTN EPVLRLAKKL IDATFADRVF 100
FCNSGAEANE AALKLARKFA HDRYGSHKSG IVAFKNAFHG RTLFTVSAGG 150
QPAYSQDFAP LPADIRHAAY NDINSASALI DDSTCAVIVE PIQGEGGVVP 200
ASNAFLQGLR ELCNRHNALL IFDEVQTGVG RTGELYAYMH YGVTPDLLTT 250
AKALGGGFPV GALLATEECA RVMTVGTHGT TYGGNPLASA VAGKVLELIN 300
TPEMLNGVKQ RHDWFVERLN TINHRYGLFS EVRGLGLLIG CVLNADYAGQ 350
AKQISQEAAK AGVMVLIAGG NVVRFAPALN VSEEEVTTGL DRFAAACEHF 400
VSRGSS 406
Length:406
Mass (Da):43,665
Last modified:February 1, 1997 - v1
Checksum:iB18ED13644C21176
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611A → R in AAB51148. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90416 Genomic DNA. Translation: AAB51148.1.
U00096 Genomic DNA. Translation: AAC74818.1.
AP009048 Genomic DNA. Translation: BAA15539.1.
PIRiD64934.
RefSeqiNP_416262.1. NC_000913.3.
YP_490009.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74818; AAC74818; b1748.
BAA15539; BAA15539; BAA15539.
GeneIDi12934011.
946255.
KEGGiecj:Y75_p1723.
eco:b1748.
PATRICi32118805. VBIEscCol129921_1820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90416 Genomic DNA. Translation: AAB51148.1 .
U00096 Genomic DNA. Translation: AAC74818.1 .
AP009048 Genomic DNA. Translation: BAA15539.1 .
PIRi D64934.
RefSeqi NP_416262.1. NC_000913.3.
YP_490009.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4ADB X-ray 2.20 A/B/C/D 1-406 [» ]
4ADC X-ray 2.30 A/B/C/D 1-406 [» ]
4ADD X-ray 2.45 A/B/C/D 1-406 [» ]
4ADE X-ray 2.75 A/B 1-406 [» ]
ProteinModelPortali P77581.
SMRi P77581. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-9145N.
IntActi P77581. 2 interactions.
STRINGi 511145.b1748.

Proteomic databases

PaxDbi P77581.
PRIDEi P77581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74818 ; AAC74818 ; b1748 .
BAA15539 ; BAA15539 ; BAA15539 .
GeneIDi 12934011.
946255.
KEGGi ecj:Y75_p1723.
eco:b1748.
PATRICi 32118805. VBIEscCol129921_1820.

Organism-specific databases

EchoBASEi EB3755.
EcoGenei EG13999. argM.

Phylogenomic databases

eggNOGi COG4992.
HOGENOMi HOG000020206.
KOi K00840.
OMAi ASNAFLH.
OrthoDBi EOG6QVRHN.
PhylomeDBi P77581.

Enzyme and pathway databases

UniPathwayi UPA00185 ; UER00281 .
BioCyci EcoCyc:SUCCORNTRANSAM-MONOMER.
ECOL316407:JW1737-MONOMER.
MetaCyc:SUCCORNTRANSAM-MONOMER.

Miscellaneous databases

PROi P77581.

Gene expression databases

Genevestigatori P77581.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
MF_01173. AstC_aminotrans_3.
InterProi IPR017652. Ac/SucOrn_transaminase_bac.
IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR026330. SOAT.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03246. arg_catab_astC. 1 hit.
TIGR00707. argD. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Escherichia coli starvation gene cstC is involved in amino acid catabolism."
    Fraley C.D., Kim J.H., McCann M.P., Matin A.
    J. Bacteriol. 180:4287-4290(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli."
    Schneider B.L., Kiupakis A.K., Reitzer L.J.
    J. Bacteriol. 180:4278-4286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 3-21 AND 295-309, FUNCTION.

Entry informationi

Entry nameiASTC_ECOLI
AccessioniPrimary (citable) accession number: P77581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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