Reviewed,
UniProtKB/Swiss-Prot P77580 (MHPF_ECOLI)
Last modified
November 25, 2008.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acetaldehyde dehydrogenase EC=1.2.1.10 Alternative name(s): Acetaldehyde dehydrogenase [acetylating] | ||||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A. Functions as a chaperone protein for folding of mhpE. |
| Catalytic activity | Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH. |
| Pathway | Aromatic compound metabolism; 3-phenylpropionic acid degradation. |
| Subunit structure | Interacts with mhpE. |
| Sequence similarities | Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | amino acid metabolic process Inferred from electronic annotation. Source: InterPro aromatic compound catabolic processInferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 316 | 316 | Acetaldehyde dehydrogenase | PRO_0000096471 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Kawamukai M. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [2] | "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12." Ferrandez A., Garcia J.L., Diaz E. J. Bacteriol. 179:2573-2581(1997) [PubMed: 9098055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / CS520. |
| [3] | "Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [4] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [5] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [6] | "Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli." Lee S.J., Ko J.H., Kang H.Y., Lee Y. Biochem. Biophys. Res. Commun. 346:1009-1015(2006) [PubMed: 16782065] [Abstract] Cited for: INTERACTION WITH MHPF, FUNCTION. |
Cross-references
Sequence databases | |
|---|---|
| D86239 Genomic DNA. Translation: BAA13056.1. Y09555 Genomic DNA. Translation: CAA70751.1. U73857 Genomic DNA. Translation: AAB18075.1. U00096 Genomic DNA. Translation: AAC73454.1. AP009048 Genomic DNA. Translation: BAE76133.1. | |
| PIR | G64762. |
| RefSeq | AP_001003.1. NP_414885.1. |
3D structure databases | |
| SMR | P77580. Positions 3-308. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 945008. |
| GenomeReviews | Gene locus b0351 in contig U00096_GR. Gene locus JW0342 in contig AP009048_GR. |
| KEGG | ecj:JW0342. eco:b0351. |
Organism-specific databases | |
| EchoBASE | EB3390. |
| EcoGene | EG13625. mhpF. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P77580. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:MHPF-MON. MetaCyc:MHPF-MON. |
Family and domain databases | |
| HAMAP | MF_01657. [Tree] |
| InterPro | IPR003361. Acetylald_dehydrogenase. IPR015426. Acetylald_DHase_C. IPR000534. Semialdehyde_DHase_NAD-bd. [Graphical view] |
| PANTHER | PTHR21123. Acetylald_dh. 1 hit. |
| Pfam | PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF015689. Actaldh_dh_actl. 1 hit. |
| TIGRFAMs | TIGR03215. ac_ald_DH_ac. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MHPF_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P77580 Secondary accession number(s): Q2MC73 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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