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Protein

Fructose-like permease IIC component 1

Gene

fryC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-6.
ECOL316407:JW2383-MONOMER.

Protein family/group databases

TCDBi4.A.2.1.11. the pts fructose-mannitol (fru) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-like permease IIC component 1
Alternative name(s):
PTS system fructose-like EIIC component 1
Gene namesi
Name:fryC
Synonyms:ypdG
Ordered Locus Names:b2386, JW2383
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14154. fryC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646CytoplasmicSequence analysisAdd
BLAST
Transmembranei47 – 6721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini68 – 10134PeriplasmicSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini123 – 1264CytoplasmicSequence analysis
Transmembranei127 – 14721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini148 – 15710PeriplasmicSequence analysis
Transmembranei158 – 17821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini179 – 19719CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini219 – 23719PeriplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini259 – 27618CytoplasmicSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini298 – 31821PeriplasmicSequence analysisAdd
BLAST
Transmembranei319 – 33921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini340 – 3412CytoplasmicSequence analysis
Transmembranei342 – 36221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini363 – 37816PeriplasmicSequence analysisAdd
BLAST
Transmembranei379 – 39921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini400 – 41516CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Fructose-like permease IIC component 1PRO_0000186704Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP77579.

Interactioni

Protein-protein interaction databases

BioGridi4260562. 9 interactions.
STRINGi511145.b2386.

Structurei

3D structure databases

ProteinModelPortaliP77579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 410376PTS EIIC type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIIC type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410863U. Bacteria.
COG1299. LUCA.
HOGENOMiHOG000122934.
KOiK11203.
OMAiWAWPLVS.
OrthoDBiEOG6XDGX2.
PhylomeDBiP77579.

Family and domain databases

InterProiIPR003352. PTS_EIIC.
IPR013014. PTS_EIIC_2.
[Graphical view]
PfamiPF02378. PTS_EIIC. 1 hit.
[Graphical view]
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKRSATV VPGASGAAAA VKNPQASKTS FWGELPQHVM SGISRMVPTL
60 70 80 90 100
IMGGVILAFS QLIAYSWLKI PAEIGIMDAL NSGKFSGFDL SLLKFAWLSQ
110 120 130 140 150
SFGGVLFGFA IPMFAAFVAN SIGGKLAFPA GFIGGLMSTQ PTQLLNFDPS
160 170 180 190 200
TMQWATSSPV PSTFIGALII SIVAGYLVKW MNQKIQLPDF LLAFKTTFLL
210 220 230 240 250
PILSAIFVML AMYYVITPFG GWINGGIRTV LTAAGEKGAL MYAMGIAAAT
260 270 280 290 300
AIDLGGPINK AAGFVAFSFT TDHVLPVTAR SIAIVIPPIG LGLATIIDRR
310 320 330 340 350
LTGKRLFNAQ LYPQGKTAMF LAFMGISEGA IPFALESPIT AIPSYMVGAI
360 370 380 390 400
VGSTAAVWLG AVQWFPESAI WAWPLVTNLG VYMAGIALGA VITALMVVFL
410
RLMMFRKGKL LIDSL
Length:415
Mass (Da):43,966
Last modified:February 1, 1997 - v1
Checksum:i76C2CB5EBF0946B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75445.1.
AP009048 Genomic DNA. Translation: BAA16256.1.
PIRiG65012.
RefSeqiNP_416887.1. NC_000913.3.
WP_000985359.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75445; AAC75445; b2386.
BAA16256; BAA16256; BAA16256.
GeneIDi949111.
KEGGiecj:JW2383.
eco:b2386.
PATRICi32120151. VBIEscCol129921_2484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75445.1.
AP009048 Genomic DNA. Translation: BAA16256.1.
PIRiG65012.
RefSeqiNP_416887.1. NC_000913.3.
WP_000985359.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260562. 9 interactions.
STRINGi511145.b2386.

Protein family/group databases

TCDBi4.A.2.1.11. the pts fructose-mannitol (fru) family.

Proteomic databases

PaxDbiP77579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75445; AAC75445; b2386.
BAA16256; BAA16256; BAA16256.
GeneIDi949111.
KEGGiecj:JW2383.
eco:b2386.
PATRICi32120151. VBIEscCol129921_2484.

Organism-specific databases

EchoBASEiEB3906.
EcoGeneiEG14154. fryC.

Phylogenomic databases

eggNOGiENOG410863U. Bacteria.
COG1299. LUCA.
HOGENOMiHOG000122934.
KOiK11203.
OMAiWAWPLVS.
OrthoDBiEOG6XDGX2.
PhylomeDBiP77579.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-6.
ECOL316407:JW2383-MONOMER.

Miscellaneous databases

PROiP77579.

Family and domain databases

InterProiIPR003352. PTS_EIIC.
IPR013014. PTS_EIIC_2.
[Graphical view]
PfamiPF02378. PTS_EIIC. 1 hit.
[Graphical view]
PROSITEiPS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiPTFC1_ECOLI
AccessioniPrimary (citable) accession number: P77579
Secondary accession number(s): P78196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.