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Protein

Mhp operon transcriptional activator

Gene

mhpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 5320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Aromatic hydrocarbons catabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6201-MONOMER.
ECOL316407:JW0337-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mhp operon transcriptional activator
Gene namesi
Name:mhpR
Ordered Locus Names:b0346, JW0337
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20276. mhpR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Mhp operon transcriptional activatorPRO_0000201763Add
BLAST

Proteomic databases

EPDiP77569.
PaxDbiP77569.

Interactioni

Protein-protein interaction databases

BioGridi4260667. 12 interactions.
DIPiDIP-10211N.
IntActiP77569. 4 interactions.
STRINGi511145.b0346.

Structurei

3D structure databases

ProteinModelPortaliP77569.
SMRiP77569. Positions 12-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7463HTH iclR-typePROSITE-ProRule annotationAdd
BLAST
Domaini89 – 262174IclR-EDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH iclR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 iclR-ED (iclR effector binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108K2P. Bacteria.
COG1414. LUCA.
HOGENOMiHOG000230079.
InParanoidiP77569.
KOiK05818.
OMAiIIRETTH.
PhylomeDBiP77569.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR014757. Tscrpt_reg_IclR_C.
IPR005471. Tscrpt_reg_IclR_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09339. HTH_IclR. 1 hit.
PF01614. IclR. 1 hit.
[Graphical view]
SMARTiSM00346. HTH_ICLR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS51077. HTH_ICLR. 1 hit.
PS51078. ICLR_ED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNNEQTEYK TVRGLTRGLM LLNMLNKLDG GASVGLLAEL SGLHRTTVRR
60 70 80 90 100
LLETLQEEGY VRRSPSDDSF RLTIKVRQLS EGFRDEQWIS ALAAPLLGDL
110 120 130 140 150
LREVVWPTDV STLDVDAMVV RETTHRFSRL SFHRAMVGRR LPLLKTASGL
160 170 180 190 200
TWLAFCPEQD RKELIEMLAS RPGDDYQLAR EPLKLEAILA RARKEGYGQN
210 220 230 240 250
YRGWDQEEKI ASIAVPLRSE QRVIGCLNLV YMASAMTIEQ AAEKHLPALQ
260 270
RVAKQIEEGV ESQAILVAGR RSGMHLR
Length:277
Mass (Da):31,322
Last modified:June 26, 2007 - v2
Checksum:i79240A3D14165AAB
GO

Sequence cautioni

The sequence AAB18070 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA13051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE76128 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA70746 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491L → Q in BAA13051 (Ref. 2) Curated
Sequence conflicti256 – 27722IEEGV…GMHLR → NRRRG in BAA13051 (Ref. 2) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09555 Genomic DNA. Translation: CAA70746.1. Different initiation.
D86239 Genomic DNA. Translation: BAA13051.1. Different initiation.
U73857 Genomic DNA. Translation: AAB18070.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73449.2.
AP009048 Genomic DNA. Translation: BAE76128.1. Different initiation.
PIRiB64762.
RefSeqiNP_414880.2. NC_000913.3.
WP_001301325.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73449; AAC73449; b0346.
BAE76128; BAE76128; BAE76128.
GeneIDi945938.
KEGGiecj:JW0337.
eco:b0346.
PATRICi32115825. VBIEscCol129921_0354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09555 Genomic DNA. Translation: CAA70746.1. Different initiation.
D86239 Genomic DNA. Translation: BAA13051.1. Different initiation.
U73857 Genomic DNA. Translation: AAB18070.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73449.2.
AP009048 Genomic DNA. Translation: BAE76128.1. Different initiation.
PIRiB64762.
RefSeqiNP_414880.2. NC_000913.3.
WP_001301325.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77569.
SMRiP77569. Positions 12-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260667. 12 interactions.
DIPiDIP-10211N.
IntActiP77569. 4 interactions.
STRINGi511145.b0346.

Proteomic databases

EPDiP77569.
PaxDbiP77569.

Protocols and materials databases

DNASUi945938.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73449; AAC73449; b0346.
BAE76128; BAE76128; BAE76128.
GeneIDi945938.
KEGGiecj:JW0337.
eco:b0346.
PATRICi32115825. VBIEscCol129921_0354.

Organism-specific databases

EchoBASEiEB4169.
EcoGeneiEG20276. mhpR.

Phylogenomic databases

eggNOGiENOG4108K2P. Bacteria.
COG1414. LUCA.
HOGENOMiHOG000230079.
InParanoidiP77569.
KOiK05818.
OMAiIIRETTH.
PhylomeDBiP77569.

Enzyme and pathway databases

BioCyciEcoCyc:G6201-MONOMER.
ECOL316407:JW0337-MONOMER.

Miscellaneous databases

PROiP77569.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR014757. Tscrpt_reg_IclR_C.
IPR005471. Tscrpt_reg_IclR_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09339. HTH_IclR. 1 hit.
PF01614. IclR. 1 hit.
[Graphical view]
SMARTiSM00346. HTH_ICLR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS51077. HTH_ICLR. 1 hit.
PS51078. ICLR_ED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMHPR_ECOLI
AccessioniPrimary (citable) accession number: P77569
Secondary accession number(s): P71202, Q2MC78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.