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Protein

DNA-binding transcriptional activator MhpR

Gene

mhpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi34 – 53H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processAromatic hydrocarbons catabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6201-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding transcriptional activator MhpRCurated
Alternative name(s):
mhp operon transcriptional activator
Gene namesi
Name:mhpR
Ordered Locus Names:b0346, JW0337
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20276 mhpR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002017631 – 277DNA-binding transcriptional activator MhpRAdd BLAST277

Proteomic databases

EPDiP77569
PaxDbiP77569
PRIDEiP77569

Interactioni

Protein-protein interaction databases

BioGridi4260667, 12 interactors
DIPiDIP-10211N
IntActiP77569, 4 interactors
STRINGi316385.ECDH10B_1358

Structurei

3D structure databases

ProteinModelPortaliP77569
SMRiP77569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 74HTH iclR-typePROSITE-ProRule annotationAdd BLAST63
Domaini89 – 262IclR-EDPROSITE-ProRule annotationAdd BLAST174

Phylogenomic databases

eggNOGiENOG4108K2P Bacteria
COG1414 LUCA
HOGENOMiHOG000230079
InParanoidiP77569
KOiK05818
OMAiMIIRETT
PhylomeDBiP77569

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR029016 GAF-like_dom_sf
IPR014757 Tscrpt_reg_IclR_C
IPR005471 Tscrpt_reg_IclR_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF09339 HTH_IclR, 1 hit
PF01614 IclR, 1 hit
SMARTiView protein in SMART
SM00346 HTH_ICLR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51077 HTH_ICLR, 1 hit
PS51078 ICLR_ED, 1 hit

Sequencei

Sequence statusi: Complete.

P77569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNNEQTEYK TVRGLTRGLM LLNMLNKLDG GASVGLLAEL SGLHRTTVRR
60 70 80 90 100
LLETLQEEGY VRRSPSDDSF RLTIKVRQLS EGFRDEQWIS ALAAPLLGDL
110 120 130 140 150
LREVVWPTDV STLDVDAMVV RETTHRFSRL SFHRAMVGRR LPLLKTASGL
160 170 180 190 200
TWLAFCPEQD RKELIEMLAS RPGDDYQLAR EPLKLEAILA RARKEGYGQN
210 220 230 240 250
YRGWDQEEKI ASIAVPLRSE QRVIGCLNLV YMASAMTIEQ AAEKHLPALQ
260 270
RVAKQIEEGV ESQAILVAGR RSGMHLR
Length:277
Mass (Da):31,322
Last modified:June 26, 2007 - v2
Checksum:i79240A3D14165AAB
GO

Sequence cautioni

The sequence AAB18070 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA13051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE76128 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA70746 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249L → Q in BAA13051 (Ref. 2) Curated1
Sequence conflicti256 – 277IEEGV…GMHLR → NRRRG in BAA13051 (Ref. 2) CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09555 Genomic DNA Translation: CAA70746.1 Different initiation.
D86239 Genomic DNA Translation: BAA13051.1 Different initiation.
U73857 Genomic DNA Translation: AAB18070.1 Different initiation.
U00096 Genomic DNA Translation: AAC73449.2
AP009048 Genomic DNA Translation: BAE76128.1 Different initiation.
PIRiB64762
RefSeqiNP_414880.2, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC73449; AAC73449; b0346
BAE76128; BAE76128; BAE76128
GeneIDi945938
KEGGiecj:JW0337
eco:b0346
PATRICifig|1411691.4.peg.1932

Similar proteinsi

Entry informationi

Entry nameiMHPR_ECOLI
AccessioniPrimary (citable) accession number: P77569
Secondary accession number(s): P71202, Q2MC78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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